CDKN2A Protein, cyclin-dependent kinase inhibitor 2A

CDKN2A

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CDKN2A

Official Full Name cyclin-dependent kinase inhibitor 2A
Background The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene(isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.
Synonyms CDKN2A; cyclin-dependent kinase inhibitor 2A; Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a); cyclin-dependent kinase inhibitor 2A, isoform 3; CDK4I; p16-INK4; p16-INK4a; mitochondrial smARF; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor protein; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • 13-TAT
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDKN2A-1060H Recombinant Human CDKN2A Protein, GST-Tagged Wheat Germ GST
    Human CDKN2A-10H Recombinant Human CDKN2A protein E.coli N/A
    Human CDKN2A-117H Recombinant Human CDKN2A Protein, 13-residue TAT-tagged E.coli 13-TAT
    Human CDKN2A-27912TH Recombinant Human CDKN2A E.coli N/A
    Human CDKN2A-655H Recombinant Human CDKN2A protein E.coli N/A
    Human CDKN2A-7616HCL Recombinant Human CDKN2A 293 Cell Lysate HEK293 N/A
    Human CDKN2A-7704H Recombinant Human CDKN2A protein, His & T7-tagged E.coli His/T7
    Mouse CDKN2A-3223M Recombinant Mouse CDKN2A Protein Mammalian Cell His
    Mouse Cdkn2a-7705M Recombinant Mouse Cdkn2a protein, His & T7-tagged E.coli His/T7
    Rat CDKN2A-1313R Recombinant Rat CDKN2A Protein Mammalian Cell His
    Rat Cdkn2a-7706R Recombinant Rat Cdkn2a protein, His & T7-tagged E.coli His/T7
    Chicken CDKN2A-6004C Recombinant Chicken CDKN2A Mammalian Cell His

    CDKN2A involved in several pathways and played different roles in them. We selected most pathways CDKN2A participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis YWHAQ; AKT1; CRADD; TNFRSF10C; IL3RA; IRF4A; PIK3CA; HMGB2A; HIST1H1E; PIK3R2
    Apoptosis Modulation and Signaling SEPT4; DIABLO; HN1; BCL2L11; CRADD; BLK; DAXX; BIK; CASP2; HRK
    Bladder cancer VEGFA; HRAS; RB1; CCND1; ERBB2; SRC; RASSF1; MAP2K1; TP53; CXCL8
    Cell Cycle SMC4; CDC14AB; NDC80; HIST4H4; PKMYT1; BRCC3; AKAP9; FGFR1OP; PTTG1; TERF2IP
    Cell Cycle, Mitotic TUBGCP3; TMPO; LIN52; KNTC1; ENSAB; NDC80; MAPRE1; ZW10; ZWILCH; SDCCAG8
    Cellular Senescence ACD; CBX6A; CBX4; IGFBP7; AGO1; H3F3B.1; CDKN2D; HMGA1B; HIST2H3C; ERF
    Cellular responses to stress HIST1H1D; SUZ12; KDM6B; WIPI2; RPS19BP1; EED; RRAGA; HIF1AN; CDKN2B; CEBPB

    CDKN2A has several biochemical functions, for example, DNA binding, MDM2/MDM4 family protein binding, NF-kappaB binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2A itself. We selected most functions CDKN2A had, and list some proteins which have the same functions with CDKN2A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HIST1H3C; AKAP8L; MESP1; RBPJB; RFX5; ZFP382; ZBED2; LIG3; ZBTB42; GTF2A1
    MDM2/MDM4 family protein binding PSME3; CAV1; CDK5RAP3; TRP53; CDKN2A; RFWD3; PPARA
    NF-kappaB binding COMMD6; ANXA4; CPNE1; NFKBID; ANKRD42; GSK3B; RPS3; MTDH; RNF25; NPM1
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN2C; CDKN1BA; CDKN2A; HEXIM2; CDKN1BB; CDKN2B; KAT2B; CDKN1C; CDKN1D; INCA1
    p53 binding BRD4; USP10; STK11; HSPD1; EHMT2; ZNF385B; TP53BP1; TP73; SETD7; PSME3
    poly(A) RNA binding ELAVL1; ZC3H10; MACF1; RIMS1; EEF1A1; CPNE3; SSB; CCDC47; SF3B4; RBMS2
    protein binding TLX2; TREML1; TIMM8A; ADAMTSL3; SH3GLB1; DST; HIST1H4B; TBK1; SLC7A11; SOCS7
    protein kinase binding NPR1; CCNB1; CACNB2; CCND2; TP73; TRAF4; PPP1R15A; ITGB2; PAX6; TRAF2
    transcription factor binding PIM1; PPARG; CEBPA; EPAS1; HES6; ZBTB49; MSX2; Ar; EGR1; TAF1
    ubiquitin-protein transferase inhibitor activity CDKN2A; GLMN

    CDKN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2A.

    CDK4; CDK6

    Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).
    Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).

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