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Recombinant Human CDKN2A Protein, GST-Tagged

Cat.No. : CDKN2A-1060H
Product Overview : Human CDKN2A full-length ORF (AAH15960, 1 a.a. - 105 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 37.29 kDa
AA Sequence : MMMGSAQVAELLLLHGAEPNCADPA TLTRPVHDAAREGFLDTLVVLHRAG ARLDVRDAWGRLPVDLAEELGHRDV ARYLRAAAGGTRGSNHARIDAAEGP SDIPD
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CDKN2A cyclin-dependent kinase inhibitor 2A [ Homo sapiens ]
Official Symbol : CDKN2A
Synonyms : CDKN2A; cyclin-dependent kinase inhibitor 2A; CDKN2, cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), MLM; ARF; CDK4I; CMM2; INK4; INK4a; MTS1; p14; p16; p16INK4a; p19; p19Arf; CDK4 inhibitor p16-INK4; multiple tumor suppressor 1; cell cycle negative regulator beta; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); MLM; P14; P16; P19; TP16; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A;
Gene ID : 1029
mRNA Refseq : NM_000077
Protein Refseq : NP_000068
MIM : 600160
UniProt ID : P42771

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is CDKN2A testing common in cancer diagnostics? 10/14/2022

Yes, CDKN2A testing is often included in genetic screenings for individuals with a family history of cancer to assess their risk.

Can CDKN2A testing be used for early cancer detection? 04/04/2022

Yes, CDKN2A testing is being investigated as a potential tool for early cancer detection, especially in high-risk individuals.

In which types of cancer is CDKN2A most commonly implicated? 07/07/2021

CDKN2A mutations are frequently found in melanoma, pancreatic cancer, and certain types of familial cancers.

How can knowledge of CDKN2A status influence cancer treatment decisions? 03/02/2020

Understanding CDKN2A status can guide treatment choices, as certain therapies may be more or less effective based on the presence or absence of functional CDKN2A.

Are there any known side effects associated with CDKN2A-targeted therapies? 06/13/2018

The field is still evolving, but as with many targeted therapies, potential side effects are being monitored, and their impact is being studied.

Customer Reviews (3)

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Reviews
05/12/2022

    As a researcher utilizing the CDKN2A protein in my trials, I have experienced notable advantages that contribute to the efficiency and success of my research.

    11/29/2019

      The CDKN2A protein offers exceptional quality.

      10/02/2016

        The manufacturer's responsive and knowledgeable support team is always available to answer my queries or provide guidance, ensuring that I can proceed with my research smoothly and without delays.

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