celsr3
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  • Official Full Name
  • cadherin, EGF LAG seven-pass G-type receptor 3
  • Background
  • The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
  • Synonyms
  • CELSR3; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); cadherin EGF LAG seven pass G type receptor 3, flamingo (Drosophila) homolog , EGFL1; cadherin EGF LAG seven-pass G-type receptor 3; CDHF11; FMI1; HFMI1; MEGF2; anchor
Cat.#:CELSR3-1110HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CELSR3 Protein, GST-Tagged
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Cat.#:CELSR3-474HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CELSR3 Protein, His-tagged
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Cat.#:Celsr3-475MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Celsr3 Protein, His-tagged
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Cat.#:CELSR3-3279MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CELSR3 Protein
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Cat.#:CELSR3-1332RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CELSR3 Protein
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Involved Pathway

CELSR3 involved in several pathways and played different roles in them. We selected most pathways CELSR3 participated on our site, such as GPCRs, Other, Non-odorant GPCRs, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELSR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
GPCRs, Other
VMN1R54; VMN1R40; MRGPRH; CELSR1; EMR2; OR10A5; OR3A4P; GPR55; CELSR2; VMN1R49
Non-odorant GPCRs
EMR4; GPR15; BAI2; OPN3; RRH; O3far1; CELSR1; GPR132; CELSR3

Protein Function

CELSR3 has several biochemical functions, for example, G-protein coupled receptor activity, calcium ion binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CELSR3 itself. We selected most functions CELSR3 had, and list some proteins which have the same functions with CELSR3. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein TAAR15; OR2K2; GRM3; TAAR4; OPN1SW2; TACR3A; CXCR3.2; OR51B2; TAS2R140; TAS2R143
Function calcium ion binding
Related Protein ANXA9; PCDH11Y; PLA2G4B; EFCAB6; CAPN2B; VCAN; PCDH1GB9; SPOCK2; SNCB; KCNIP4
Function signal transducer activity
Related Protein ECM1; STAT1A; SH2B3; MIER1A; CXCR4A; TRHR2; ADRA1BB; DRD2L; CELSR3; TAAR12E
Function transmembrane signaling receptor activity
Related Protein GPR133; LILRB3; ERBB2; DCC; FCGR2C; ICAM1; VIPR1B; TLR1; CD4; EVI2A

Interacting Protein

CELSR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELSR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELSR3.
Csf1