cfb
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  • Official Full Name
  • complement factor B
  • Background
  • Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
  • Synonyms
  • CFB; complement factor B; BF; FB; BFD; GBG; CFAB; PBF2; AHUS4; FBI12; H2-Bf; FLJ54899; C3 proactivator; C3/C5 convertase; C3 proaccelerator; OTTHUMP00000029283; properdin factor B; B-factor, properdin; glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein
Cat.#:CFB-334HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CFB Protein, His-tagged
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Cat.#:CFB-1161HTag:His
Source (Host):HEK293EBNA2Species:Human
Product nameRecombinant Human CFB Protein, His-Tagged
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Cat.#:CFB-1162HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CFB Protein, GST-Tagged
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Cat.#:CFB-1164MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CFB Protein, His-tagged
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Cat.#:CFB-11132HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFB, GST-tagged
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Cat.#:CFB-141HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CFB protein, His-tagged
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Cat.#:CFB-2106HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFB protein, His & GST-tagged
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Cat.#:CFB-26760THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFB, His-tagged
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Cat.#:CFB-26762THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CFB, His-tagged
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Cat.#:CFB-444HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human complement factor B, His-tagged
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Cat.#:CFB-Bb-2479HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human CFB-Bb, His-tagged
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Cat.#:Cfb-2107MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cfb protein, His-tagged
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Cat.#:Cfb-2108RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cfb protein, His-tagged
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Cat.#:Cfb-2109RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cfb protein, His & GST-tagged
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Cat.#:Cfb-2110RTag:His/MBP
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cfb protein, His & MBP-tagged
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Cat.#:CFB-8924ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CFB
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Cat.#:CFB-104HTag:
Source (Host):Species:Human
Product nameNative Human Factor B
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Cat.#:CFB-7558HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CFB 293 Cell Lysate
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Involved Pathway

CFB involved in several pathways and played different roles in them. We selected most pathways CFB participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
CFB; Serpina1c; C4BPB; CR1L; MASP2; F9; C4BPA; CFH; F11; LOC100514666
Staphylococcus aureus infection
ITGAM; C1R; HLA-DMB; HLA-DPA1; HLA-DQA2; MBL2; FGG; FCGR3B; C2; GM5077

Protein Function

CFB has several biochemical functions, for example, complement binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFB itself. We selected most functions CFB had, and list some proteins which have the same functions with CFB. You can find most of the proteins on our site.
Function
Related Protein
Function complement binding
Related Protein CR2; CFB; CD59; C8G; C8A; CD46
Function serine-type endopeptidase activity
Related Protein ELA2L; TMPRSS5; GM5077; GZMC; F12; ST14; PRSS37; F9; KLK12; IMMP1L

Interacting Protein

CFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFB here. Most of them are supplied by our site. Hope this information will be useful for your research of CFB.
vco3_najka; RPA2; LAMC3; d-mannose; ALB; Nedd1

CFB Related Articles

Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
Yamamoto, K; Takeuchi, T; et al. Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial. MODERN RHEUMATOLOGY 24:552-560(2014).