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CHRM5

  • Official Full Name

    cholinergic receptor, muscarinic 5

  • Overview

    The muscarinic acetylcholine receptor M5 is a member of the GPCR family (subfamily, acetylcholine) which mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. The rimary transducing effect is PI turnover. The receptor has been reported to be expressed in blood, brain, and ovary. ESTs have been isolated from human testis and placenta libraries.
  • Synonyms

    CHRM5; cholinergic receptor, muscarinic 5; HM5; MGC41838; muscarinic acetylcholine receptor M5; OTTHUMP00000159731;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRM5-1275H Recombinant Human CHRM5 Protein Wheat Germ N/A
Human CHRM5-1276H Recombinant Human CHRM5 Protein, GST-Tagged Wheat Germ GST
Human CHRM5-7518HCL Recombinant Human CHRM5 293 Cell Lysate HEK293 N/A
Human CHRM5-1097HFL Recombinant Human CHRM5 protein, His&Flag-tagged HEK293 His&Flag 1-532 aa
Human CHRM5-3224HF Recombinant Full Length Human CHRM5 Protein In Vitro Cell Free System 2897 amino acids
Mouse CHRM5-3428M Recombinant Mouse CHRM5 Protein Mammalian Cell His
Mouse CHRM5-1661M-B Recombinant Mouse CHRM5 Protein Pre-coupled Magnetic Beads HEK293
Mouse CHRM5-1661M Recombinant Mouse CHRM5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CHRM5-1388R Recombinant Rat CHRM5 Protein Mammalian Cell His
Rat CHRM5-1046R-B Recombinant Rat CHRM5 Protein Pre-coupled Magnetic Beads HEK293
Rat CHRM5-1046R Recombinant Rat CHRM5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL9585HF Recombinant Full Length Human Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-532)
Macaca mulatta (Rhesus macaque) RFL35707MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-532)
Mus musculus (Mouse) RFL21311MF Recombinant Full Length Mouse Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-532)
Pan troglodytes (Chimpanzee) RFL5160PF Recombinant Full Length Pan Troglodytes Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-532)
Rattus norvegicus (Rat) RFL137RF Recombinant Full Length Rat Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-531)
Rhesus Macaque CHRM5-862R Recombinant Rhesus monkey CHRM5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CHRM5-688R Recombinant Rhesus Macaque CHRM5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CHRM5-688R-B Recombinant Rhesus Macaque CHRM5 Protein Pre-coupled Magnetic Beads HEK293
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) RFL10596SF Recombinant Full Length Saimiri Boliviensis Boliviensis Muscarinic Acetylcholine Receptor M5(Chrm5) Protein, His-Tagged E.coli expression system His Full Length (1-532)
Chicken CHRM5-3194C Recombinant Chicken CHRM5 Mammalian Cell His
Kit-0972 TR-FRET RAR alpha Coactivator Assay Kit, goat N/A
Kit-1174 CHRM5 Activated GPCR Internalization Assay Kit N/A
Kit-1175 CHRM5 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRM5 Related Articles
  • CHRM5 Related Research Area

CHRM5 involved in several pathways and played different roles in them. We selected most pathways CHRM5 participated on our site, such as Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsADRA1D;DRD5;DRD3;ADRA2A;ADRB1;ADRB3;DRD4;DRD2;CHRM1
Calcium Regulation in the Cardiac CellRGS5;PKIG;GJB1;CHRM2;CX34.4;RGS14A;KCNB1;GJA10;CX27.5
Calcium signaling pathwayTNNC1;DRD1B;PDGFRB;CALM2A;PLCB3;P2RX3A;SLC8A1B;NOS2A;HTR2A
Cholinergic synapseAKR1C1;NRAS;GNAI2;PIK3CD;KCNJ2;PLCB1;AKT1;CREB5;CHRNB4
Class A/1 (Rhodopsin-like receptors)RGS1;AMCF-II;ADORA2A;APLN;ACKR4;GPR132;SST;APLNR;GPR37L1
G alpha (q) signalling eventsNPFF;UTS2;LPAR2B;KALRN;RASGRP2;GPR65;GPR132;PMCH;GPR17
GPCR downstream signalingS1PR3;OPN5;GPR17;CXCL13;GPR65;SST;ARHGEF18;TAS2R3;DRD3
GPCR ligand bindingPROK1;KEL;PENKA;PTGDR2;ADORA3;INSL3;TAS2R7;QRFPR;OPN1SW

CHRM5 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM5 itself. We selected most functions CHRM5 had, and list some proteins which have the same functions with CHRM5. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled acetylcholine receptor activityCHRM5;CHRM5A;CHRM5B;CHRM2A;CHRM3;CHRM1;CHRM4;CHRM2
phosphatidylinositol phospholipase C activityCHRM3;CCL5;CCR5;C3AR1;PLCB3;PLCH2;PLCG1;BDKRB2;PLCL1

CHRM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM5.

Meixner, M; Atanasova, S; et al. Expression of Acetylcholine Receptors by Experimental Rat Renal Allografts. BIOMED RESEARCH INTERNATIONAL :-(2014).
Lin, HJ; Wan, L; et al. Muscarinic Acetylcholine Receptor 3 Is Dominant in Myopia Progression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:6519-6525(2012).
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