chrnb1
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  • Official Full Name
  • cholinergic receptor, nicotinic, beta 1 (muscle)
  • Background
  • The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.
  • Synonyms
  • CHRNB1; cholinergic receptor, nicotinic, beta 1 (muscle); acetylcholine receptor subunit beta; Acetylcholine receptor protein beta chain precursor; ACHB_HUMAN; ACHRB; Cholinergic receptor nicotinic beta polypeptide 1 (muscle); Chrnb 1; CHRNB; CMS1D; CMS2A; Nicotinic acetylcholine receptor beta subunit precursor; SCCMS; cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Cat.#:CHRNB1-1285HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHRNB1 Protein, GST-Tagged
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Cat.#:CHRNB1-3438MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHRNB1 Protein
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Cat.#:CHRNB1-1396RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CHRNB1 Protein
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Cat.#:Chrnb1-3054RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Chrnb1, His-tagged
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Cat.#:CHRNB1-3055CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHRNB1, His-tagged
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Cat.#:CHRNB1-8108ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CHRNB1
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Cat.#:CHRNB1-187HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CHRNB1 lysate
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Involved Pathway

CHRNB1 involved in several pathways and played different roles in them. We selected most pathways CHRNB1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
GH2; GHR; CHRNE; TAAR4; HRH4; ADRB3B; APLNRB; MC2R; CGNRH-R; MC5RA

Protein Function

CHRNB1 has several biochemical functions, for example, contributes_to acetylcholine binding, acetylcholine binding, contributes_to acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB1 itself. We selected most functions CHRNB1 had, and list some proteins which have the same functions with CHRNB1. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to acetylcholine binding
Related Protein CHRNA1; CHRND; CHRNA2A; CHRNA6; CHRNA10; CHRNB3A; CHRNA3; CHRNB4; CHRNB3B; CHRNA2
Function acetylcholine binding
Related Protein CHRNB1; CHRNB3; CHRNA4; CHRFAM7A; CHRNA7; CHRNB2; ACHE; CHRNA3; CHRM3
Function contributes_to acetylcholine receptor activity
Related Protein CHRND; CHRNA10; CHRNA10A; CHRNA1; CHRNA2A; CHRNA9; CHRNB3A; CHRNA4B; CHRNB1; CHRFAM7A
Function contributes_to acetylcholine-activated cation-selective channel activity
Related Protein CHRNA10A; CHRNA9; CHRNB1; CHRFAM7A; CHRNA2A; CHRNB3A; CHRNA1; CHRNB3B; CHRNA4B; ZACN
Function channel activity
Related Protein PANX1B; PANX1A; PANX2; GJA8; CHRNB1; P2RX6; MAL; BAXA; BAX; BCL2
Function ligand-gated ion channel activity
Related Protein CHRNA5; CLCA5; TRPA1B; Chrng; CHRNA3; ZACN; P2RX2; CHRNB2; CLCA2; CHRNA4

Interacting Protein

CHRNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB1.
COPS6

CHRNB1 Related Articles

Lindstrom, J; Luo, J; et al. Myasthenia gravis and the tops and bottoms of AChRs - Antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. MYASTHENIA GRAVIS AND RELATED DISORDERS: 11TH INTERNATIONAL CONFERENCE 1132:29-41(2008).
Hayashi, K; et al. Biochemical studies on functional proteins in the brain nervous system. Neurobiochemical studies on nerve growth factor. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 116:286-308(1996).
SINE, SM; CLAUDIO, T; et al. STABLE EXPRESSION OF THE MOUSE NICOTINIC ACETYLCHOLINE-RECEPTOR IN MOUSE FIBROBLASTS - COMPARISON OF RECEPTORS IN NATIVE AND TRANSFECTED CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY 266:13679-13689(1991).