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CHRNB1

  • Official Full Name

    cholinergic receptor, nicotinic, beta 1 (muscle)

  • Overview

    The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.
  • Synonyms

    CHRNB1; cholinergic receptor, nicotinic, beta 1 (muscle); acetylcholine receptor subunit beta; Acetylcholine receptor protein beta chain precursor; ACHB_HUMAN; ACHRB; Cholinergic receptor nicotinic beta polypeptide 1 (muscle); Chrnb 1; CHRNB; CMS1D; CMS2A; Nicotinic acetylcholine receptor beta subunit precursor; SCCMS; cholinergic receptor, nicotinic, beta polypeptide 1 (muscle);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRNB1-1285H Recombinant Human CHRNB1 Protein, GST-Tagged Wheat Germ GST
Human CHRNB1-187HCL Recombinant Human CHRNB1 lysate HEK293 N/A
Mouse CHRNB1-3438M Recombinant Mouse CHRNB1 Protein Mammalian Cell His
Mouse CHRNB1-1668M Recombinant Mouse CHRNB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CHRNB1-1668M-B Recombinant Mouse CHRNB1 Protein Pre-coupled Magnetic Beads HEK293
Rat Chrnb1-3054R Recombinant Rat Chrnb1, His-tagged E.Coli or Yeast His 501
Rat CHRNB1-1396R Recombinant Rat CHRNB1 Protein Mammalian Cell His
Rat CHRNB1-1054R-B Recombinant Rat CHRNB1 Protein Pre-coupled Magnetic Beads HEK293
Rat CHRNB1-1054R Recombinant Rat CHRNB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CHRNB1-8108Z Recombinant Zebrafish CHRNB1 Mammalian Cell His
Chicken CHRNB1-3055C Recombinant Chicken CHRNB1, His-tagged E.Coli or Yeast His 118
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRNB1 Related Articles
  • CHRNB1 Related Research Area

CHRNB1 involved in several pathways and played different roles in them. We selected most pathways CHRNB1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionTHRAA;PTGER2;LPAR2;TAAR14I;PTGER1C;TAAR15;LOC780933;HTR1A;LEP

CHRNB1 has several biochemical functions, for example, contributes_to acetylcholine binding, acetylcholine binding, contributes_to acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB1 itself. We selected most functions CHRNB1 had, and list some proteins which have the same functions with CHRNB1. You can find most of the proteins on our site.

Function Related Protein
contributes_to acetylcholine bindingCHRNA9;CHRNA10;CHRNA1;CHRNA4B;CHRNA2A;CHRNA5;CHRNA6;CHRNA3;CHRNA10A
acetylcholine bindingCHRM3;CHRNA3;CHRFAM7A;CHRNA7;CHRNB1;CHRNB3;ACHE;CHRNB2;CHRNA4
contributes_to acetylcholine receptor activityCHRNB3A;CHRNA9;CHRNA2A;CHRNA1;CHRND;CHRNA4B;CHRNA10;CHRNA10A;ZACN
contributes_to acetylcholine-activated cation-selective channel activityZACN;CHRNB1L;CHRNA10A;CHRNB3A;CHRNA9;CHRNB3B;CHRNA1;CHRNB1;CHRNA10
channel activityBAXB;PANX2;P2RX6;PANX1B;STEAP1;BCL2;PANX1A;BAXA;BAX
ligand-gated ion channel activityCLCA2;P2RX2;GABRB1;CHRNA5;CNGA3;CHRNA4;TRPA1B;ANXA6;CHRNB4

CHRNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB1.

COPS6

Lindstrom, J; Luo, J; et al. Myasthenia gravis and the tops and bottoms of AChRs - Antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. MYASTHENIA GRAVIS AND RELATED DISORDERS: 11TH INTERNATIONAL CONFERENCE 1132:29-41(2008).
Hayashi, K; et al. Biochemical studies on functional proteins in the brain nervous system. Neurobiochemical studies on nerve growth factor. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 116:286-308(1996).
SINE, SM; CLAUDIO, T; et al. STABLE EXPRESSION OF THE MOUSE NICOTINIC ACETYLCHOLINE-RECEPTOR IN MOUSE FIBROBLASTS - COMPARISON OF RECEPTORS IN NATIVE AND TRANSFECTED CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY 266:13679-13689(1991).
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