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Official Full Name CHRNB3 cholinergic receptor, nicotinic, beta 3
Background The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[
Synonyms CHRNB3; cholinergic receptor, nicotinic, beta 3; neuronal acetylcholine receptor subunit beta-3; OTTHUMP00000229136; cholinergic receptor, nicotinic, beta polypeptide 3; acetylcholine receptor, neuronal nicotinic, beta-3 subunit
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHRNB3-1288H Recombinant Human CHRNB3 Protein, GST-Tagged Wheat Germ GST
    Human CHRNB3-672H Recombinant Human CHRNB3 Protein, Fc-tagged HEK293 Fc
    Human CHRNB3-673H Recombinant Human CHRNB3 Protein, His-tagged HEK293 His
    Human CHRNB3-7893H Recombinant Human CHRNB3 protein, His & T7-tagged E.coli His/T7
    Mouse CHRNB3-3440M Recombinant Mouse CHRNB3 Protein Mammalian Cell His
    Rat CHRNB3-1398R Recombinant Rat CHRNB3 Protein Mammalian Cell His
    Chicken CHRNB3-6375C Recombinant Chicken CHRNB3 Mammalian Cell His

    CHRNB3 involved in several pathways and played different roles in them. We selected most pathways CHRNB3 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction CHRND; IL12; HTR5AL; LEP; TAAR4; TRHRB; HRH4; GRIN1B; TAAR8A; P2RY6

    CHRNB3 has several biochemical functions, for example, acetylcholine binding, acetylcholine-activated cation-selective channel activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB3 itself. We selected most functions CHRNB3 had, and list some proteins which have the same functions with CHRNB3. You can find most of the proteins on our site.

    Function Related Protein
    acetylcholine binding ACHE; CHRNA4; CHRFAM7A; CHRM3; CHRNB2; CHRNB3; CHRNA7; CHRNA3; CHRNB1
    acetylcholine-activated cation-selective channel activity CHRNB2; CHRNA10A; CHRNA2A; CHRNB3A; CHRND; CHRNB3B; CHRNB3; CHRNA2; CHRNA5; Chrng
    drug binding PYGL; CYP2D6; CYP4B1; DRD1; SRP54; DRD2; PYGB; SLC6A4A; ABP1; HTR2A
    extracellular ligand-gated ion channel activity CHRNB3A; CHRNB3B; SIX2A; GABRR1; GABRP; CHRNA10A; GLRBB; GABRR2A; CHRNA4B; GABRA6A
    ion channel activity P2RX8; KCNH2A; FXYD6; SCN4AB; SCN12AA; CHRNA2A; CACNA1SA; TRPM1B; SCN8AA; KCNH1B

    CHRNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB3.

    Tseng, TS; Park, JY; et al. Role of Nicotine Dependence on the Relationship between Variants in the Nicotinic Receptor Genes and Risk of Lung Adenocarcinoma. PLOS ONE 9:-(2014).
    Bar-Shira, A; Gana-Weisz, M; et al. CHRNB3 c.-57A > G functional promoter change affects Parkinson's disease and smoking. NEUROBIOLOGY OF AGING 35:-(2014).

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