• Official Full Name
  • carbohydrate (chondroitin 4) sulfotransferase 12
  • Background
  • The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5 UTRs have been found for this gene.
  • Synonyms
  • CHST12; carbohydrate (chondroitin 4) sulfotransferase 12; carbohydrate sulfotransferase 12; C4S 2; C4ST2; C4S2; C4ST 2; Chondroitin 4 O sulfotransferase 2; Chondroitin 4 sulfotransferase 2; Sulfotransferase Hlo; chondroitin 4-sulfotransferase 2; chondroitin 4-O-sulfotransferase 2; C4S-2; C4ST-2
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHST12 Protein, GST-Tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHST12, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHST12 Protein
Source (Host):Species:Human
Product nameRecombinant Human CHST12 293 Cell Lysate

Involved Pathway

CHST12 involved in several pathways and played different roles in them. We selected most pathways CHST12 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

Protein Function

CHST12 has several biochemical functions, for example, 3-phosphoadenosine 5-phosphosulfate binding, chondroitin 4-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST12 itself. We selected most functions CHST12 had, and list some proteins which have the same functions with CHST12. You can find most of the proteins on our site.
Related Protein
Function 3-phosphoadenosine 5-phosphosulfate binding
Related Protein CHST15; HS3ST5; ENPP1; GAL3ST4; CHST12
Function chondroitin 4-sulfotransferase activity
Related Protein CHST11; CHST12

Interacting Protein

CHST12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST12.
UGGT1; Gspt1; Mzt2; CBX8