• Official Full Name
  • carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
  • Background
  • The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD).
  • Synonyms
  • CHST6; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6; MCDC1; carbohydrate sulfotransferase 6; C GlcNAc6ST; Carbohydate sulfotransferase 6; Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 6; Corneal N acetylglucosamine 6 sulfotransferase; Galactose N acetylglucosamine N acetylglucosamine 6 O sulfotransferase 4 beta; GlcNAc6ST 5; GST4 beta; hCGn6ST; Macular dystrophy corneal 1; gn6st-5; GST4-beta; C-GlcNAc6ST; glcNAc6ST-5; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sulfotransferase; corneal N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHST6 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHST6 Protein, His-tagged
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CHST6 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHST6
Source (Host):Species:Human
Product nameRecombinant Human CHST6 293 Cell Lysate

Involved Pathway

CHST6 involved in several pathways and played different roles in them. We selected most pathways CHST6 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan biosynthesis - keratan sulfate

Protein Function

CHST6 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST6 itself. We selected most functions CHST6 had, and list some proteins which have the same functions with CHST6. You can find most of the proteins on our site.
Related Protein
Function N-acetylglucosamine 6-O-sulfotransferase activity
Related Protein HS3ST3B1A; HS3ST3L; CHST3A; CHST2; Chst5; SULT1ST3; SULT5A1; SULT1ST2; SULT1ST1; CHST4

CHST6 Related Articles

Nakayama, F; Umeda, S; et al. Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines. FEBS LETTERS 587:231-237(2013).
Di Iorio, E; Barbaro, V; et al. Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea. EXPERIMENTAL EYE RESEARCH 91:293-299(2010).