cited2
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  • Official Full Name
  • Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
  • Background
  • The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; cbp/p300-interacting transactivator 2; Cbp/p300 interacting transactivator 2; Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2; CITE2_HUMAN; CITED 2; MRG 1; MRG-1; MRG1; MSG related protein 1; MSG-related protein 1; P35srj; MSG1-related gene 1; melanocyte-specific gene 1-related gene 1
Cat.#:CITED2-1387HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CITED2 Protein, GST-tagged
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Cat.#:CITED2-3247HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CITED2 Protein, MYC/DDK-tagged
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Cat.#:CITED2-1353HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CITED2, His-tagged
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Cat.#:CITED2-27073THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CITED2, His-tagged
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Cat.#:CITED2-27074THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CITED2, His-tagged
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Cat.#:CITED2-3487MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CITED2 Protein
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Cat.#:CITED2-7085CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CITED2
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Cat.#:CITED2-1559ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CITED2
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Cat.#:CITED2-359HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CITED2 cell lysate
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Involved Pathway

CITED2 involved in several pathways and played different roles in them. We selected most pathways CITED2 participated on our site, such as HIF-1-alpha transcription factor network, HIF-2-alpha transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CITED2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HIF-1-alpha transcription factor network
EGLN3; TFF3; NDRG1; PLIN2; GATA2; ADM; NPM1; CITED2; CP; COPS5
HIF-2-alpha transcription factor network
EGLN3; CITED2; HIF1AN; EGLN2

Protein Function

CITED2 has several biochemical functions, for example, LBD domain binding, RNA polymerase II transcription coactivator activity, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CITED2 itself. We selected most functions CITED2 had, and list some proteins which have the same functions with CITED2. You can find most of the proteins on our site.
Function
Related Protein
Function LBD domain binding
Related Protein CITED1; MED1; CITED2; PROX1
Function RNA polymerase II transcription coactivator activity
Related Protein RERE; CITED2; MEF2A; CREBBP; TRIM28; SMARCA4; SOX12; MED12L; NEUROD1; PITX2
Function RNA polymerase II transcription corepressor activity
Related Protein HDAC1; SIN3A; TXLNB; URI1; N4BP2L2; HDGF; UXT; RBBP8; TFAP2B; NFIB
Function chromatin binding
Related Protein PHF8; BARX2; TFAP2A; HDGF2; ASH1L; MBD1; RNF2; SIRT2; NKX6-1; APITD1
Function histone acetyltransferase binding
Related Protein GLI3; PCNA; TAF7L; CITED2; TP53; PAX6; KAT2B; TRIP4; SP1; SIRT2
Function protein binding
Related Protein IFT20; NHEJ1; RAMP2; CCDC25; NRF1; EIF5A2; EML1; LAMTOR2; AKAP17A; MATN2
Function transcription coactivator activity
Related Protein CTBP2; YAF2; STIL; SUB1; PSMC3; NPM1; KAT5; UTF1; CREBBP; MTF1
Function transcription corepressor activity
Related Protein JUB; KCNA3; SRSF2; CTBP2A; LHX1; TFCP2L1; TBL1XR1B; CTBP2; SIRT1; SSX5
Function transcription factor activity, sequence-specific DNA binding
Related Protein SLC12A9; SOX11A; KLF3; CDX1A; ZHX3; HOXC8A; SIX4; ZKSCAN14; ZKSCAN3; NR1D2A

Interacting Protein

CITED2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CITED2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CITED2.
HNF4A; EP300; TFAP2C; TFAP2A; TFAP2B; tsr; q9x365_bacan