clcn3
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  • Official Full Name
  • chloride channel, voltage-sensitive 3
  • Background
  • This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • CLCN3; chloride channel, voltage-sensitive 3; chloride channel 3; H(+)/Cl(-) exchange transporter 3; ClC 3; CLC3; chloride channel protein 3; chloride transporter ClC-3; ClC-3; DKFZp564I0463
Cat.#:CLCN3-1417HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLCN3 Protein, GST-tagged
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Cat.#:CLCN3-3514MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLCN3 Protein
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Cat.#:CLCN3-1426RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLCN3 Protein
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Protein Function

CLCN3 has several biochemical functions, for example, ATP binding, PDZ domain binding, antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCN3 itself. We selected most functions CLCN3 had, and list some proteins which have the same functions with CLCN3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AGK; VSIG8B; ZRANB3; ATP1A1A.4; MAPK14B; MYO18A; FGFR2; MAPK14A; GRK7A; SMC2
Function PDZ domain binding
Related Protein SLC26A6; TGFBR3; Apba1; LNX2; Fzd4; NLGN1; GRIK2; KCNJ4; ARHGAP29; FZD7
Function antiporter activity
Related Protein SLC7A6; SLC35E2; SLC9A3.1; TMCO3; SLC24A4; SLC35D1B; CLCN4; SLC9A6A; CLCN7; SLC47A1
Function chloride channel activity
Related Protein SLC26A1; GABRR3; GABRG2; CLCA3; CFTR; GABRA6A; SLC26A3.2; SLC26A6; CLIC2; CLIC5B
Function ion channel activity
Related Protein TRPV2; P2RX5; CHRNA2A; CHRNB3; GRIK3; SCN4AA; KCNC1B; KCNH1A; KCNH2A; SCN8AB
Function nucleotide binding
Related Protein HNRNPR; CDC42L2; DPYDB; MSI2; MYO15; GNAI2A; RIPK4; MYH4; DQX1; RBM42
Function protein heterodimerization activity
Related Protein HIST1H2BP; H2AFZ; SDCBP; HIST1H3A; SYT16; VEGFA; MEIS1; HIST3H2A; HIST1H2AA; P4HB
Function voltage-gated chloride channel activity
Related Protein CLCNKA; CLCN1A; CLCN6; CLCN7; ANO6; CLCNKB; CLCNK; CLCN1; CLCN3; CLCN4
Function voltage-gated ion channel activity
Related Protein PKD2; TPC3; CACNA1SA; NALCN; KCNA6A; SCN4AB; KCNC3B; CLIC4; CLIC1; KCNC2
Function NOT volume-sensitive chloride channel activity
Related Protein CLCN3

Interacting Protein

CLCN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCN3.
Ywhae