Recombinant Human CLCN3 Protein, GST-tagged
Cat.No. : | CLCN3-1417H |
Product Overview : | Human CLCN3 partial ORF ( NP_001820.2, 1 a.a. - 99 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.63 kDa |
AA Sequence : | MESEQLFHRGYYRNSYNSITSASSD EELLDGAGVIMDFQTSEDDNLLDGD TAVGTHYTMTNGGSINSSTHLLDLL DEPIPGVGTYDDFHTIDWVREKCK |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CLCN3 chloride channel, voltage-sensitive 3 [ Homo sapiens ] |
Official Symbol : | CLCN3 |
Synonyms : | CLCN3; chloride channel, voltage-sensitive 3; chloride channel 3; H(+)/Cl(-) exchange transporter 3; ClC 3; CLC3; chloride channel protein 3; chloride transporter ClC-3; ClC-3; DKFZp564I0463; |
Gene ID : | 1182 |
mRNA Refseq : | NM_001243372 |
Protein Refseq : | NP_001230301 |
MIM : | 600580 |
UniProt ID : | P51790 |
Products Types
◆ Recombinant Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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