CLDN8 Protein, Claudin 8


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Official Full Name Claudin 8
Background This intronless gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a paracellular cation barrier.
Synonyms Cldn8; claudin 8; claudin-8; AI648025
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLDN8-1448H Recombinant Human CLDN8 Protein, GST-tagged Wheat Germ GST
    Human CLDN8-7458HCL Recombinant Human CLDN8 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CLDN8-898R Recombinant Rhesus monkey CLDN8 Protein, His-tagged Mammalian Cell His
    Zebrafish CLDN8-1075Z Recombinant Zebrafish CLDN8 Mammalian Cell His

    CLDN8 involved in several pathways and played different roles in them. We selected most pathways CLDN8 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) BLA; NRXN3A; NCAM1B; NEO1A; NTNG1; CLDN22; ITGA6B; NEO1; SDC4; NFASC
    Leukocyte transendothelial migration PXN; ESAM; ARHGAP35; MYL12B; CLDN16; VCAM1; MMP9; NCF4; CLDN20; CLDN3
    Hepatitis C OAS2; IFNA21; TLR3; PPP2CB; NRAS; KRAS; MAPK1; IFNA2; TRAF3; PPP2R1B

    CLDN8 has several biochemical functions, for example, identical protein binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN8 itself. We selected most functions CLDN8 had, and list some proteins which have the same functions with CLDN8. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding HCN2; S100A2; VWA2; PPP5C; ATL1; MTSS1; ALK; PCNA; ASMT; MSANTD3
    protein binding DMKN; TCEB2; RAB3A; AMHR2; ANP32A; RNF182; CLN5; ATXN1L; SMC1A; IL1R1
    structural molecule activity CLDN18; KRT72-PS; PNN; CDC42SE1; FGB; COPB2; JUP; KRT42; MATR3; DCTN3

    CLDN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN8.

    SYNE4; CCDC155

    Buckley, MM; O'Halloran, KD; et al. Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome. JOURNAL OF PHYSIOLOGY-LONDON 592:5235-5250(2014).
    Nassour, H; Dubreuil, JD; et al. Escherichia coli STb Enterotoxin Dislodges Claudin-1 from Epithelial Tight Junctions. PLOS ONE 9:-(2014).

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