CLN3

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CLN3

Official Full Name ceroid-lipofuscinosis, neuronal 3
Background This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms CLN3; ceroid-lipofuscinosis, neuronal 3; BTS; JNCL; battenin; batten disease protein;
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cln3-902M Recombinant Mouse Cln3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CLN3-1505H Recombinant Human CLN3 Protein, GST-tagged Wheat Germ GST
    Human CLN3-3252H Recombinant Human CLN3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CLN3-367HCL Recombinant Human CLN3 cell lysate N/A
    Mouse CLN3-3591M Recombinant Mouse CLN3 Protein Mammalian Cell His
    Cynomolgus Monkey CLN3-410C Recombinant Cynomolgus CLN3 Protein, His-tagged Mammalian Cell His
    Zebrafish CLN3-1699Z Recombinant Zebrafish CLN3 Mammalian Cell His

    CLN3 involved in several pathways and played different roles in them. We selected most pathways CLN3 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysosome SORT1B; ATP6V0CA; NPC1; CTNS; ATP6AP1; SORT1A; PSAPL1; SGSH; Ctsl; ATP6V0C

    CLN3 has several biochemical functions, for example, protein binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLN3 itself. We selected most functions CLN3 had, and list some proteins which have the same functions with CLN3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SLC9A3R2; LARP4; LRPAP1; KNG1; C9orf100; ARPC2; ZNF302; IARS; RPL14; KIF20B
    unfolded protein binding CLN3; ST13; CCT7; HSPA1A; HSP90AA1.1; HSP104; CHAF1A; HSP90AA1; DNAJB13; CALR3B

    CLN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLN3.

    ESYT2; XPO1; XPOT; ATG7; RPN2; CYC1; ABCD3; PHB; VDAC2; IRAK1; NPEPPS; GEMIN4; PRKDC; SLC25A11; GANAB; TRIP13; IMMT; HSD17B12; RIF1

    Ratajczak, E; Petcherski, A; et al. FRET-Assisted Determination of CLN3 Membrane Topology. PLOS ONE 9:-(2014).
    Getty, A; Kovacs, AD; et al. Osmotic Stress Changes the Expression and Subcellular Localization of the Batten Disease Protein CLN3. PLOS ONE 8:-(2013).

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