cltc
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  • Official Full Name
  • clathrin, heavy chain (Hc)
  • Background
  • Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CLTC; clathrin, heavy chain (Hc); Hc; CHC; CHC17; CLH-17; CLTCL2; clathrin heavy chain 1; clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; clathrin heavy chain on chromosome 17;
Cat.#:CLTC-26707THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLTC, GST-tagged
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Cat.#:CLTC-3612MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CLTC Protein
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Cat.#:CLTC-1471RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CLTC Protein
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Cat.#:CLTC-3605CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CLTC
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Involved Pathway

CLTC involved in several pathways and played different roles in them. We selected most pathways CLTC participated on our site, such as Adaptive Immune System, Arf6 trafficking events, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLTC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KIF3B; ASB10; LRR1; CTSLL; KIFAP3; ITK; EGF; VPRBP; CHUK; LILRA3
Arf6 trafficking events
CLTC; CTNNA1; CHRM2; EXOC3; SPAG9; ADRB2; EXOC6; PTBP3; EXOC1; EXOC5
Axon guidance
PTK2; GNAI1; NTN1A; PAK3; RHOD; HRAS; EPHB4B; RANBP9; DLG4; ACTR2
Bacterial invasion of epithelial cells
DNM1; SEPT1; RAC1; WASF1; SHC4; SEPT11; ITGB1; CDC42; CBLB; CAV2
Beta-catenin independent WNT signaling
CLTA; AP2A2; GNB5; AGO2; MOV10; AP2M1; DVL1; AP2B1; ROR2; CLTB
Clathrin derived vesicle budding
DTNBP1; BLOC1S3; AP1M2; PLDN; NECAP1; GAK; AP1G1; PPIAL4A; AP1B1; APPA
Developmental Biology
DRAP1; BOC; KDR; PSPN; DUSP9; KALRN; HELZ2; LGI2B; NTN1B; INSM1B
EPH-Ephrin signaling
EFNA1A; KDR; EFNB1; EPHA2; ARPC1A; KALRN; EFNA3B; MYL12A; EFNB3; EFNA2A

Protein Function

CLTC has several biochemical functions, for example, clathrin light chain binding, double-stranded RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLTC itself. We selected most functions CLTC had, and list some proteins which have the same functions with CLTC. You can find most of the proteins on our site.
Function
Related Protein
Function clathrin light chain binding
Related Protein CALY; NSG2; NSG1; CLTC; HMP19
Function double-stranded RNA binding
Related Protein DDX21; DHX58; TLR3; DICER1; TLR8; AGO3; IFIH1; AGO2; AGO1; LRRFIP1
Function poly(A) RNA binding
Related Protein EIF3D; EXOSC7; PCBP1; HDGF; CISD2; HIST1H4C; ALDOA; CCDC124; YARS2; RPS8
Function protein binding
Related Protein TBRG1; KDM1A; IL15RA; EEA1; SEMA4C; KLK5; ARHGEF10; DDX47; CCNG1; KBTBD6
Function protein kinase binding
Related Protein FGFR1OP; ADRA2A; LLGL1; PDPK1; VRK1; CENPJ; IRS2; STAP1; MSH2; JAK2
Function structural molecule activity
Related Protein CLDND; ISCA2; TUBB; LAD1; CLDN15LA; CLDN1; LMNL3; LCE3C; CLDNB; KRTT1C19E

Interacting Protein

CLTC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLTC here. Most of them are supplied by our site. Hope this information will be useful for your research of CLTC.
OCRL; TNK2; IKBKB; IKBKE; HIP1; C10orf88; TOM1L1