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COL11A2

Official Full Name

collagen, type XI, alpha 2
Overview

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
Synonyms

COL11A2; collagen, type XI, alpha 2; DFNA13, DFNB53; collagen alpha-2(XI) chain; HKE5; COBA2_HUMAN; Collagen alpha 2(XI); Collagen type XI alpha 2; DAQB-79P13.8; DFNA13; HGNC:2187; PARP; STL3; pro-a2 chain of collagen type XI; DFNB53;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COL11A2-1635H	Recombinant Human COL11A2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Zebrafish	COL11A2-4947Z	Recombinant Zebrafish COL11A2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
COL11A2 Related Articles

COL11A2 involved in several pathways and played different roles in them. We selected most pathways COL11A2 participated on our site, such as Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Focal adhesion	RAF1A;RAC3B;ACTG1;VCL;PPP1R12B;PAK2;PIK3R5;BIRC2;FYN
ECM-receptor interaction	COL3A1;TNXB;SV2C;ITGB1A;COL2A1B;TNW;GP9;LAMA4;COL11A2

COL11A2 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COL11A2 itself. We selected most functions COL11A2 had, and list some proteins which have the same functions with COL11A2. You can find most of the proteins on our site.

Function	Related Protein
extracellular matrix structural constituent	PXDN;COL5A1;PRELP;FBLN2;COMP;MUC5AC;IMPG2;COL27A1;CHI3L1

COL11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL11A2.

Oh, CD; Maity, SN; et al. Identification of SOX9 Interaction Sites in the Genome of Chondrocytes. PLOS ONE 5:-(2010).

Lee, HS; Lee, AT; et al. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. MOLECULAR MEDICINE 14:293-300(2008).