COL17A1
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Official Full Name
collagen, type XVII, alpha 1
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Overview
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. -
Synonyms
COL17A1; collagen, type XVII, alpha 1; BPAG2; collagen alpha-1(XVII) chain; BP180; alpha 1 type XVII collagen; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII,;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Confidential
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- N
- GST
- Tag Free
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | COL17A1-7378HCL | Recombinant Human COL17A1 293 Cell Lysate | HEK293 | N/A |
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| Human | COL17A1-329H | Recombinant Human COL17A1 Protein, His-tagged | E.coli | His | Pro184~Pro375 |
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| Human | COL17A1-4947H | Recombinant Human COL17A1 protein, His-tagged | E.coli | His | 1253-1497aa |
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| Human | COL17A1-0589H | Recombinant Human COL17A1 Protein, Tag Free | Confidential | Tag Free |
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| Human | COL17A1-1775H | Recombinant Human COL17A1 Protein (Pro184-Thr301), N-His tagged | E.coli | N-His | Pro184-Thr301 |
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| Human | COL17A1-1774H | Recombinant Human COL17A1 Protein (Glu490-Arg566), N-GST tagged | E.coli | N-GST | Glu490-Arg566 |
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| Mouse | COL17A1-3721M | Recombinant Mouse COL17A1 Protein | Mammalian Cell | His |
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| Mouse | COL17A1-1851M-B | Recombinant Mouse COL17A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | COL17A1-1851M | Recombinant Mouse COL17A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- COL17A1 Related Articles
COL17A1 involved in several pathways and played different roles in them. We selected most pathways COL17A1 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL17A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alpha6-Beta4 Integrin Signaling Pathway | RTKN;MST1R;DSP;CD151;COL17A1;PLEC;YWHAQ;EGFR;EIF4E |
| Cell junction organization | CLDN16;PLECA;CTNND1;CD151;CDH12;F11R.2;CLDN3;CDH3;LIMS1 |
| Cell-Cell communication | CD151;CLDN23;FBLIM1;CDH13;CDH9;CDH10;CLDN20;DSCAMA;SPTBN1 |
| Collagen biosynthesis and modifying enzymes | COL8A1A;ADAMTS2;COL23A1;ADAMTS3;SERPINH1B;LEPREL2;COL11A1B;SERPINH1A;COL4A5 |
| Collagen degradation | CTSK;CTSD;CTSL1;MGC174857;EMID2;COL13A1;COL19A1;COL9A1;MMP15 |
| Collagen formation | P3H2;BMP1A;COL25A1;COL3A1;SERPINH1B;PCOLCEB;CTSL1;COL9A1;LOXL3 |
| Degradation of the extracellular matrix | ADAM8;COL13A1;BMP1A;MMP24;BMP1;MMP10;MMP8;COL9A3;ADAMTS1 |
| Extracellular matrix organization | CD151;MUSK;CEACAM8;FURINA;MATN1;MGC174857;FAM49BA;ELANE;TLL2 |
COL17A1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL17A1 itself. We selected most functions COL17A1 had, and list some proteins which have the same functions with COL17A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SEC23B;RBBP4;TBC1D5;ARF4;UNKL;SFRS9;TMEM51;ZNF302;C12orf68 |
COL17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL17A1.
ssdna_dtdc; EGFR
- Q&As
- Reviews
Q&As (5)
Ask a questionCOL17A1 protein interacts with integrins, laminins, and other extracellular matrix proteins to maintain skin integrity.
Dysregulation of COL17A1 protein can trigger autoimmunity and lead to the development of autoimmune skin diseases such as bullous pemphigoid.
Are there any known interactions between COL17A1 protein and other cellular components?
Mutations in COL17A1 have been associated with certain forms of cancer, indicating a potential role in tumor progression and metastasis.
COL17A1 protein levels can be measured using techniques such as western blotting, ELISA, and immunohistochemistry.
Customer Reviews (3)
Write a reviewBy incorporating the COL17A1 Protein into their studies, scientists have the opportunity to conduct their research with utmost confidence, paving the way for groundbreaking discoveries and novel insights in their respective fields.
Considering the aforementioned qualities, I wholeheartedly recommend the COL17A1 Protein to fellow researchers in search of a top-tier protein solution that not only meets their experimental needs but also benefits from exceptional technical support.
What further sets the COL17A1 Protein apart is the outstanding technical support provided by the manufacturer.
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