col17a1
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  • Official Full Name
  • collagen, type XVII, alpha 1
  • Background
  • This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
  • Synonyms
  • COL17A1; collagen, type XVII, alpha 1; BPAG2; collagen alpha-1(XVII) chain; BP180; alpha 1 type XVII collagen; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII,
Cat.#:COL17A1-329HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL17A1 Protein, His-tagged
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Cat.#:COL17A1-3721MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL17A1 Protein
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Cat.#:COL17A1-7378HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COL17A1 293 Cell Lysate
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Involved Pathway

COL17A1 involved in several pathways and played different roles in them. We selected most pathways COL17A1 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL17A1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway
PLEC; DST; MST1R; CLCA1; YWHAQ; RTKN; CD151L; CDKN1A; EIF4EB; EGFR
Cell junction organization
CADM2B; PVRL2L; CLDN20; DST; CLDN4; PLEC; CDH4; CDH10A; CADM2A; CLDN3
Cell-Cell communication
KIRREL3L; SPTBN1; NPHS1; LIMS1; CLDN7; CTNND1; DST; DSCAM; COL17A1A; ANG
Collagen biosynthesis and modifying enzymes
COL4A4; COL4A6; COL2A1; COL17A1A; COL19A1; COL6A1; COL5A1; COL3A1; COL1A1; COL9A1B
Collagen degradation
MGC174857; MMP20; COL23A1; EMID2; CTSB; MMP10; ELANE; CTSLL; MGC174155; MMP15
Collagen formation
TLL1; PCOLCEB; SERPINH1B; COL23A1; CTSB; SERPINH1; COL8A1; COL8A1A; CTSL2; MMP20
Degradation of the extracellular matrix
ELANE; CTS7; COL17A1; MGC174155; MMP13; TIMP2B; MMP11; TLDC2; COL9A3; BMP1B
Extracellular matrix organization
MMP17; SERPINH1A; COL6A1; COL4A6; ELANE; COL28A1; FBN1; CTSG; MFAP3; CTSB

Protein Function

COL17A1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL17A1 itself. We selected most functions COL17A1 had, and list some proteins which have the same functions with COL17A1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TAG-260; DDX39A; TAX1BP3; UBE2IB; S100A6; APLF; TTC8; COG4; DERL2; TRAPPC4

Interacting Protein

COL17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL17A1.
ssdna_dtdc; EGFR

COL17A1 Related Articles

Krenacs, T; Kiszner, G; et al. Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis. HISTOCHEMISTRY AND CELL BIOLOGY 138:653-667(2012).
Levell, NJ; Wingfield, CG; et al. Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. BRITISH JOURNAL OF DERMATOLOGY 164:1326-1328(2011).