COL1A1 Protein, collagen, type I, alpha 1

COL1A1

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COL1A1

Official Full Name collagen, type I, alpha 1
Background Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
Synonyms COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • P.pastoris
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL1A1-114H Recombinant Human COL1A1 Protein, His-tagged CHO His
    Human COL1A1-001H Recombinant Human COL1A1 Protein, His-tagged HEK293T His
    Human COL1A1-113H Recombinant Human COL1A1, GST-tagged Wheat Germ GST
    Human COL1A1-1206H Recombinant Human Collagen, Type I, Alpha 1 P.pastoris N/A
    Human COL1A1-26195TH Native Human COL1A1 N/A
    Human COL1A1-66H Recombinant Human COL1A1 protein, His-tagged E.coli His
    Human COL1A1-67H Recombinant Human COL1A1 protein, His-tagged E.coli His
    Human COL1A1-71H Recombinant Human COL1A1 protein E.coli N/A
    Mouse Col1a1-08M Recombinant Mouse Col1a1 protein, His-tagged HEK293 His
    Mouse Col1a1-09M Recombinant Mouse Col1a1 protein, His-tagged E.coli His
    Mouse COL1A1-23M Native Mouse Collagen I Protein N/A
    Rat COL1A1-1517R Recombinant Rat COL1A1 Protein Mammalian Cell His

    COL1A1 involved in several pathways and played different roles in them. We selected most pathways COL1A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amoebiasis LAMA1; RAB7B; RAB7A; PRKACA; SERPINB13; COL5A2; PIK3CD; PLCB1; SERPINB1B; RAB7
    Assembly of collagen fibrils and other multimeric structures COL4A6; MMP13; COL10A1A; COL8A1; COL1A1; LOXL3; COL5A3B; COL10A1; COL4A3; LOX
    Binding and Uptake of Ligands by Scavenger Receptors COL3A1; APOA1B; IGLC2; CD163; Alb; COL1A2; STAB2; HSPH1; HPX; IGKV1-5
    Collagen biosynthesis and modifying enzymes SERPINH1B; COL1A1; COL11A1B; LEPREL2; COL1A2; COL9A3; COL4A4; COL5A2; COL19A1; COL6A2
    Collagen formation EMID2; COL28A1D; COL8A1A; COL28A1; COL9A3; COL19A1; PCOLCEB; COL5A3B; PCOLCE2B; COL13A1
    ECM-receptor interaction SPP1; COL27A1B; SV2B; ITGB5; ITGB6; COL1A2; ITGAV; CD47; IBSP; COL11A2
    Extracellular matrix organization BGNA; COL28A1; MMP19; MMP12; ADAMTS2; COL6A2; MFAP1B; MATN1; COL13A1; COL5A3B
    Focal Adhesion COL6A4; ACTG1; CAPN2; ITGB5; FIGF; COL27A1B; COL2A1B; PAK6B; ACTN3; PPP1CB

    COL1A1 has several biochemical functions, for example, extracellular matrix structural constituent, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL1A1 itself. We selected most functions COL1A1 had, and list some proteins which have the same functions with COL1A1. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent COL11A1A; LAMB1; COL5A3B; COL27A1; IMPG1; COL1A1B; COL8A2; COL4A4; COL2A1B; FBN2B
    identical protein binding KRTAP10-5; PTPRG; SNX1; COL7A1; TRA@; ITGA2B; FHIT; CLDN4; FADD; DCTPP1
    metal ion binding HMOX1; ZFYVE16; RAB11FIP4A; ZFP641; CA15C; ZNF804A; SMYD3; MYLIPB; PPARG; FCNA
    platelet-derived growth factor binding COL2A1; COL1A2; COL6A1; PDGFA; PDGFB; PDGFRB; COL5A1; COL3A1; Pdgfa&Pdgfb; COL1A1
    protein binding DHPS; KHDC1A; DPM1; PRAM1; TBXA2R; TEK; AIMP2; SMPD1; ACO1; AK3

    COL1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL1A1.

    all3_aedae; COCH; FN1; q5yb85_strsg; TFAP2A; ZNF16; LOX; yscP; q5nfy4_fratt; thrS2; syd; q8d1r8_yerpe; queA; TFAP2C; ATP13A2; irp1

    Sinder, BP; Salemi, JD; et al. Rapidly growing Brtl/ plus mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment. BONE 71:115-123(2015).
    Noh, SMM; Kadir, SHSA; et al. Effects of ranibizumab on the extracellular matrix production by human Tenon's fibroblast. EXPERIMENTAL EYE RESEARCH 127:236-242(2014).

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