col1a1
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  • Official Full Name
  • collagen, type I, alpha 1
  • Background
  • Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
  • Synonyms
  • COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
Cat.#:COL1A1-114HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human COL1A1 Protein, His-tagged
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Cat.#:COL1A1-113HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human COL1A1, GST-tagged
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Cat.#:COL1A1-66HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL1A1 protein, His-tagged
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Cat.#:COL1A1-67HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL1A1 protein, His-tagged
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Cat.#:COL1A1-71HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL1A1 protein
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Cat.#:Col1a1-08MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Col1a1 protein, His-tagged
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Cat.#:Col1a1-09MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Col1a1 protein, His-tagged
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Cat.#:COL1A1-1517RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COL1A1 Protein
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Cat.#:COL1A1-1206HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Collagen, Type I, Alpha 1
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Cat.#:COL1A1-26195THTag:
Source (Host):NativeSpecies:Human
Product nameNative Human COL1A1
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Cat.#:COL1A1-23MTag:
Source (Host):Species:Mouse
Product nameNative Mouse Collagen I Protein
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Involved Pathway

COL1A1 involved in several pathways and played different roles in them. We selected most pathways COL1A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
ARG1; ACTN2; Itgam&Itgb2; PIK3CD; SERPINB1; PLCB2; GNAQ; CD1d1; PRKACA; C8G
Assembly of collagen fibrils and other multimeric structures
BMP1; COL1A1; COL6A2; COL4A6; COL4A3; TLL2; MMP13; COL4A5; COL5A1; CTSL2
Binding and Uptake of Ligands by Scavenger Receptors
HSPH1; HYOU1; COL3A1; COL1A1; Alb; COL1A2; SCGB3A2; IGKC; NFX1; IGKV1-5
Collagen biosynthesis and modifying enzymes
COL10A1; CRTAP; COL4A4; BMP1; COL17A1; COL5A3A; COL25A1; PCOLCE2; SERPINH1; P3H2
Collagen formation
COL25A1; COL19A1; COL5A3B; PCOLCEA; COL6A2; COL9A1; COL9A1B; COL17A1; LOXL4; COL10A1A
ECM-receptor interaction
COL6A5; ITGA6B; ITGA9; ITGB1B.2; TNR; COL2A1; COL2A1A; LAMC1; GP9; ITGA1
Extracellular matrix organization
FBN2; FBLN1; ADAMTS3; LEPREL1; COL17A1; MMP10; COL3A1; ASPN; CTSD; COL5A3A
Focal Adhesion
PTENB; ERBB2; SRC; ITGB8; ACTN1; PTK2; BAD; PDPK1; PAK2A; CCND2A

Protein Function

COL1A1 has several biochemical functions, for example, extracellular matrix structural constituent, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL1A1 itself. We selected most functions COL1A1 had, and list some proteins which have the same functions with COL1A1. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent
Related Protein EFEMP2; COL4A3; MATN3; KAL1; COL11A1A; COL4A5; COL1A1B; COL2A1B; IMPG2; LAMC1
Function identical protein binding
Related Protein FAS; RAD52; TTR; TARDBP; CDC42BPA; MPST; UBQLN4; FADD; FXR2; EPHA4
Function metal ion binding
Related Protein TATDN1; SIRT4; ARSG; NR5A1B; HDAC7; SHHA; PLAGX; CCC2; KDM7AB; ECE1
Function platelet-derived growth factor binding
Related Protein COL6A1; PDGFB; COL3A1; Pdgfa&Pdgfb; PDGFRA; PDGFRB; COL1A2; COL5A1; COL2A1; COL4A1
Function protein binding
Related Protein CAPZA1; RGR; NEUROG3; FANCC; MTM1; LIMK1; STK36; NPPA; FXR2; INTS5

Interacting Protein

COL1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL1A1.
all3_aedae; COCH; FN1; q5yb85_strsg; TFAP2A; ZNF16; LOX; yscP; q5nfy4_fratt; thrS2; syd; q8d1r8_yerpe; queA; TFAP2C; ATP13A2; irp1

COL1A1 Related Articles

Sinder, BP; Salemi, JD; et al. Rapidly growing Brtl/ plus mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment. BONE 71:115-123(2015).
Noh, SMM; Kadir, SHSA; et al. Effects of ranibizumab on the extracellular matrix production by human Tenon's fibroblast. EXPERIMENTAL EYE RESEARCH 127:236-242(2014).