col4a3bp
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  • Official Full Name
  • collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
  • Background
  • This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • COL4A3BP; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; collagen type IV alpha-3-binding protein; ceramide transporter; CERT; GPBP; StAR related lipid transfer (START) domain containing 11; STARD11; hCERT; ceramide transfer protein; li
Cat.#:COL4A3BP-1652HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL4A3BP Protein, GST-tagged
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Cat.#:COL4A3BP-3280HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL4A3BP Protein, MYC/DDK-tagged
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Cat.#:COL4A3BP-2488HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A3BP, His-tagged
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Cat.#:COL4A3BP-11434HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A3BP, GST-tagged
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Cat.#:COL4A3BP-26193THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A3BP, His-tagged
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Cat.#:COL4A3BP-27223THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A3BP, His-tagged
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Cat.#:COL4A3BP-8648HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human COL4A3BP, His & GST tagged
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Cat.#:COL4A3BP-3738MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL4A3BP Protein
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Cat.#:COL4A3BP-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human COL4A3BP cell lysate
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Involved Pathway

COL4A3BP involved in several pathways and played different roles in them. We selected most pathways COL4A3BP participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
STARD5; CPNE7; CYP3A7-CYP3AP1; DGAT1B; ATP5H; KCNG4; PFKLB; OAZ2B; LOC100686744; CYP3A5
Metabolism of lipids and lipoproteins
FABP12; APOA4B.2; AWAT1; CYP4T8; CYP4F22; CETP; ALOX5B.3; CPNE3; DECR1; CYP24A1
Sphingolipid de novo biosynthesis
ACER1; PPM1L; COL4A3BP; OSBP; CERS3B; CERS4A; GDF1; PPM1LB; SPTLC1; VAPB
Sphingolipid metabolism
ARSH; ARSK; GLTP; SGMS2; CERK; SMPD3; SGPP1; CERS5; GBA; GDF1

Protein Function

COL4A3BP has several biochemical functions, for example, ceramide binding, ceramide transporter activity, phosphatidylinositol-4-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3BP itself. We selected most functions COL4A3BP had, and list some proteins which have the same functions with COL4A3BP. You can find most of the proteins on our site.
Function
Related Protein
Function ceramide binding
Related Protein PLEKHA8; COL4A3BP; PRRC2B
Function ceramide transporter activity
Related Protein COL4A3BP
Function phosphatidylinositol-4-phosphate binding
Related Protein PLEKHA8; CLSTN2; SNX24; GOLPH3L; PRRC2B; SH3PXD2B; OSBP; SNX3; COL4A3BP; FAM21C
Function protein binding
Related Protein MED27; NCAPD2; COPS6; UBE2Z; BCL11B; C6orf130; TMEM19; DAPK1; INS; COG1
Function protein kinase activity
Related Protein TNIK; MAP3K3; IKBKB; NPRL2; IGF1RB; PRPF4BB; PRKAA2; ACVR1L; TBK1; PDK1

Interacting Protein

COL4A3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3BP.
CSNK1G2; ITGB3BP; ARL6IP1; ACTL8; PARP2; PRKAR1A; MARK2; RTN3

COL4A3BP Related Articles

Plaisier, E; Borradori, L; et al. Anti-glomerular basement membrane nephritis and bullous pemphigoid caused by distinct anti-alpha 3(IV)NC1 and anti-BP180 antibodies in a patient with Crohn's disease. AMERICAN JOURNAL OF KIDNEY DISEASES 40:649-654(2002).
Netzer, KO; Leinonen, A; et al. The Goodpasture autoantigen - Mapping the major conformational epitope(s) of alpha 3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. JOURNAL OF BIOLOGICAL CHEMISTRY 274:11267-11274(1999).