col6a2
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  • Official Full Name
  • collagen, type VI, alpha 2
  • Background
  • This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene.
  • Synonyms
  • COL6A2; collagen, type VI, alpha 2; collagen alpha-2(VI) chain; Collagen alpha 2(VI) chain; Collagen VI alpha 2 polypeptide; PP3610; OTTHUMP00000115568; OTTHUMP00000115569; OTTHUMP00000115570; collagen VI, alpha-2 polypeptide; human mRNA for collagen VI alpha-2 C-terminal globular domain
Cat.#:COL6A2-1660HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL6A2 Protein, GST-tagged
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Cat.#:COL6A2-3282HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL6A2 Protein, MYC/DDK-tagged
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Cat.#:COL6A2-11439HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL6A2, GST-tagged
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Cat.#:COL6A2-28HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL6A2 protein, T7/His-tagged
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Cat.#:COL6A2-3746MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL6A2 Protein
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Cat.#:COL6A2-6900CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL6A2
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Cat.#:COL6A2-382HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COL6A2 cell lysate
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Involved Pathway

COL6A2 involved in several pathways and played different roles in them. We selected most pathways COL6A2 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL6A2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
COL3A1; TLL2; COL2A1; COL4A4; COL11A1B; LOXL1; PLEC; COL5A3A; TLL1; BMP1
Axon guidance
EPHA8; DPYSL3; KALRNB; ARHGEF12; PPP3CC; SPNA2; FGFR1B; FES; NRP1; GFRA1
Collagen biosynthesis and modifying enzymes
ADAMTS2; LEPREL2; COL13A1; COL5A3A; COL6A3; PCOLCE2B; SERPINH1; COL2A1; COL6A1; COL4A3
Collagen formation
BMP1A; TLL2; BMP1; COL8A2; CRTAP; P3H2; COL4A3; COL9A1A; ABHD1; COL2A1
Developmental Biology
LGI2A; CLASP1; NRTN; RNF8; CSNK2B; COL6A1; CFC1; TCF12; MYL9; SPRED2
ECM-receptor interaction
COL27A1; CD44; COL6A3; ITGA8; COL4A4; THBS3; GP1BB; THBS2; GP9; COL3A1
Extracellular matrix organization
LOXL3; CTSD; EFEMP1; EMID2; MFAP4; FBLN1; SERPINH1B; FURINA; SPARC; DAG1
Focal Adhesion
ROCK2B; PARVAA; COL27A1; AKT3A; MAPK9; COL27A1B; ITGA11A; COL6A5; PPP1R12B; SHC4

Protein Function

COL6A2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL6A2 itself. We selected most functions COL6A2 had, and list some proteins which have the same functions with COL6A2. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SETD2; HOXA10; SLC8A1; MIIP; MRC1; KIAA1958; MPP6; FOXJ2; HSP90AA1.1; CCL7

Interacting Protein

COL6A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL6A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL6A2.
COX6A2; TFAP2C; SLC38A3; DISC1