col9a1
Share
  • Official Full Name
  • collagen, type IX, alpha 1
  • Background
  • This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.
  • Synonyms
  • COL9A1; collagen, type IX, alpha 1; MED; EDM6; STL4; DJ149L1.1.2
Cat.#:COL9A1-1663HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL9A1 Protein, GST-tagged
+Inquiry
Cat.#:COL9A1-3298HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL9A1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Col9a1-336RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Col9a1 Protein, His-tagged
+Inquiry
Cat.#:COL9A1-11442HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL9A1, GST-tagged
+Inquiry
Cat.#:COL9A1-147HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL9A1, His tagged
+Inquiry
Cat.#:COL9A1-265HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL9A1, Fc-tagged
+Inquiry
Cat.#:COL9A1-3731CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL9A1
+Inquiry
Cat.#:COL9A1-758HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL9A1 cell lysate
+Inquiry
Cat.#:COL9A1-796HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL9A1 cell lysate
+Inquiry

Involved Pathway

COL9A1 involved in several pathways and played different roles in them. We selected most pathways COL9A1 participated on our site, such as Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
DPYSL2; CSF2RA; EPHA4; GNAI1; COL9A1; SPRED3; SEMA6D; DLG4; NCK2; SCN4A
Collagen biosynthesis and modifying enzymes
COL9A3; BMP1B; COL5A2; COL6A1; COL4A6; LEPREL1; COL23A1; TLL1; ADAMTS2; COL8A1A
Collagen degradation
MMP19; MMP8; COL25A1; COL9A3; COL15A1B; COL9A1; COL23A1; CTSK; MMP10; CTSL1
Collagen formation
BMP1; COL28A1; COL2A1; COL19A1; CTSS; PCOLCEB; LOXL4; COL4A5; COL8A2; COL23A1
Degradation of the extracellular matrix
TPSAB1; ADAM9; BMP1B; TIMP2; CTSD; FURINB; ADAMTS1; NID1; EMID2; MGC174155
Developmental Biology
PCSK6; CHL1; EFNA1A; NRG4; DPYSL4; GPC1A; PAK4; EFNA5; SCN4A; NRTN
ECM proteoglycans
ASPN; SPARC; HAPLN1; LRP4; ITGB3A; BGNB; BGNA; ACAN; DMP1; VCANB
Extracellular matrix organization
FBLN1; PRP; MMP19; FBLN2; MATN3B; COL6A2; PCOLCEB; F11R.2; PTPRS; COL10A1A

Protein Function

COL9A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL9A1 itself. We selected most functions COL9A1 had, and list some proteins which have the same functions with COL9A1. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent conferring tensile strength
Related Protein COL2A1; COL9A1; COL9A3
Function metal ion binding
Related Protein ESR2B; TOPAZ1; ADAR; ZFP768; CYP26C1; CDC7; B3GAT1; CFI; MUTYH; COX5B