COPE

  • Official Full Name

    coatomer protein complex, subunit epsilon

  • Overview

    The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    COPE;coatomer protein complex, subunit epsilon;coatomer subunit epsilon;epsilon COP;1110005D17Rik;Coatomer epsilon subunit;Coatomer protein complex subunit epsilon;Cope1;Epsilon coat protein;Epsilon COP I;Epsilon subunit of coatomer protein complex;FLJ13241;epsilon-coat protein;epsilon-COP

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • Rhesus macaque
  • E. coli
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
COPE-11456H Recombinant Human COPE protein, GST-tagged E. coli Human GST
COPE-3920H Recombinant Human COPE protein, His-tagged E. coli Human His
COPE-1483C Recombinant Chicken COPE Mammalian Cells Chicken His
COPE-1695H Recombinant Human COPE Protein, GST-tagged Wheat Germ Human GST
COPE-1752Z Recombinant Zebrafish COPE Mammalian Cells Zebrafish His
COPE-3776M Recombinant Mouse COPE Protein Mammalian Cells Mouse His
COPE-649H Recombinant Human coatomer protein complex, subunit epsilon, His-tagged E.coli Human His 1-308 a.a.
COPE-970R Recombinant Rhesus monkey COPE Protein, His-tagged Mammalian Cells Rhesus macaque His
COPE-7361HCL Recombinant Human COPE 293 Cell Lysate HEK293 Human Non
COPE-1884M Recombinant Mouse COPE Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
COPE-1884M-B Recombinant Mouse COPE Protein Pre-coupled Magnetic Beads HEK293 Mouse
COPE-1952HF Recombinant Full Length Human COPE Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 308 amino acids
Cope-2259M Recombinant Mouse Cope Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
COPE-3597H Recombinant Human COPE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
COPE-795R Recombinant Rhesus Macaque COPE Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
COPE-795R-B Recombinant Rhesus Macaque COPE Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    COPE involved in several pathways and played different roles in them. We selected most pathways COPE participated on our site, such as COPI Mediated Transport,Golgi to ER Retrograde Transport,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    COPI Mediated Transport COPZ1,COPB1,ARCN1B,ARCN1,COPG,ARF1,COPB2,TERFA,ARCN1A
    Golgi to ER Retrograde Transport ARCN1A,ARCN1B,COPB1,COPG,COPZ1,ARCN1,TERFA,COPB2
    Membrane Trafficking CTAGE5,COPB2,TFG,PPP6R3,MCFD2,SNAPIN,TMED10,PUM1,DTNBP1B,CLVS2
    Vesicle-mediated transport SH3D19,GJB5,GJD3,BLOC1S6,PICALM,MYO1C,GJB7,HP,TCEAL4,CLVS1

    Protein Function

    COPE has several biochemical functions, for example, protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COPE itself. We selected most functions COPE had, and list some proteins which have the same functions with COPE. You can find most of the proteins on our site.

    Function Related Protein
    protein binding USP22,CDK1,SPAG9,UGGT2,CD274,USP12,RTKN,TINF2,ADD1,FAM189B
    structural molecule activity KRT24,SEPT7,CLDN16,KRT77,LAMC3,CLDNF,CYLC1,SPRR2E,CLDN11A,CSTA

    Interacting Protein

    COPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPE here. Most of them are supplied by our site. Hope this information will be useful for your research of COPE.

    EFHC2;Copa;CASP4;COPA;malF2;TSG101;pi3p;15-deoxy-delta(12,14;midostaurin;Katna1;XRCC3;FN1;MYH6;LRRK2;NUDCD1;Erp44

    Resources

    References

    • Ksiazek, A; Zub, K; et al. Immunocompetence and high metabolic rates enhance overwinter survival in the root vole, Microtus oeconomus. BIOLOGY LETTERS 10:-(2014).
    • Popova, D; Stonier, A; et al. Representative mammalian cell culture test materials for assessment of primary recovery technologies: A rapid method with industrial applicability. BIOTECHNOLOGY JOURNAL 10:162-170(2015).

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