cope
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  • Official Full Name
  • coatomer protein complex, subunit epsilon
  • Background
  • The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • COPE; coatomer protein complex, subunit epsilon; coatomer subunit epsilon; epsilon COP; 1110005D17Rik; Coatomer epsilon subunit; Coatomer protein complex subunit epsilon; Cope1; Epsilon coat protein; Epsilon COP I; Epsilon subunit of coatomer protein complex; FLJ13241; epsilon-coat protein; epsilon-COP
Cat.#:COPE-1695HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COPE Protein, GST-tagged
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Cat.#:COPE-11456HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COPE, GST-tagged
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Cat.#:COPE-649HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human coatomer protein complex, subunit epsilon, His-tagged
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Cat.#:COPE-3776MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COPE Protein
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Cat.#:COPE-970RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COPE Protein, His-tagged
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Cat.#:COPE-1483CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COPE
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Cat.#:COPE-1752ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish COPE
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Cat.#:COPE-7361HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human COPE 293 Cell Lysate
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Involved Pathway

COPE involved in several pathways and played different roles in them. We selected most pathways COPE participated on our site, such as COPI Mediated Transport, Golgi to ER Retrograde Transport, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
COPI Mediated Transport
COPZ1; COPE; TERFA; COPB1; COPG; ARCN1B; ARF1; ARCN1; ARCN1A; COPB2
Golgi to ER Retrograde Transport
ARCN1; COPZ1; TERFA; COPB1; ARCN1A; ARCN1B; COPE; COPG; COPB2
Membrane Trafficking
CNIH; TRAPPC3; SEC22A; DNASE2; TPD52L1; DTNBP1; GAK; PUM1; EXOC1; TRAPPC10
Vesicle-mediated transport
GJA8; HIP1RB; HYOU1; ARCN1B; TRAPPC2L; SEC16B; BLOC1S4; DTNBP1B; CNO; TRAPPC5

Protein Function

COPE has several biochemical functions, for example, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COPE itself. We selected most functions COPE had, and list some proteins which have the same functions with COPE. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TRIM32; MID2; HEBP2; CCHCR1; LAMA4; KRTAP10-4; ZNF207; GADD45GIP1; AXIN1; PKIA
Function structural molecule activity
Related Protein KRT71; VCLA; LAMA5; CDC42SE1; CYT1; CLDN17; KRT81; KRT8; NCR3LG1; SEPT7

Interacting Protein

COPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPE here. Most of them are supplied by our site. Hope this information will be useful for your research of COPE.
EFHC2; Copa; CASP4; COPA; malF2; TSG101; pi3p; 15-deoxy-delta(12,14; midostaurin; Katna1; XRCC3; FN1; MYH6; LRRK2; NUDCD1; Erp44

COPE Related Articles

Popova, D; Stonier, A; et al. Representative mammalian cell culture test materials for assessment of primary recovery technologies: A rapid method with industrial applicability. BIOTECHNOLOGY JOURNAL 10:162-170(2015).
Ksiazek, A; Zub, K; et al. Immunocompetence and high metabolic rates enhance overwinter survival in the root vole, Microtus oeconomus. BIOLOGY LETTERS 10:-(2014).