COX6A1 Protein, cytochrome c oxidase subunit VIa polypeptide 1

COX6A1

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COX6A1

Official Full Name cytochrome c oxidase subunit VIa polypeptide 1
Background Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.
Synonyms COX6A1; cytochrome c oxidase subunit VIa polypeptide 1; COX6A; cytochrome c oxidase subunit 6A1, mitochondrial; mitochondrial; COX VIa L; COX VIa-L; COX6AL; CX6A1_HUMAN; Cytochrome c oxidase polypeptide VIa liver; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit 6A1; Cytochrome c oxidase subunit 6A1 mitochondrial; Cytochrome C oxidase subunit VIa homolog; Cytochrome c oxidase subunit VIA liver; Cytochrome c oxidase subunit VIA-liver; MGC104500; MS412
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cox6a1-927M Recombinant Mouse Cox6a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human COX6A1-1753H Recombinant Human COX6A1 Protein, GST-tagged Wheat Germ GST
    Human COX6A1-27583TH Recombinant Human COX6A1 Wheat Germ N/A
    Human COX6A1-7331HCL Recombinant Human COX6A1 293 Cell Lysate HEK293 N/A
    Mouse COX6A1-3817M Recombinant Mouse COX6A1 Protein Mammalian Cell His
    Chicken COX6A1-4901C Recombinant Chicken COX6A1 Mammalian Cell His
    Chicken COX6A1-4902C Recombinant Chicken COX6A1 Mammalian Cell His
    Zebrafish COX6A1-1433Z Recombinant Zebrafish COX6A1 Mammalian Cell His

    COX6A1 involved in several pathways and played different roles in them. We selected most pathways COX6A1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease ADAM10; NDUFS4; NDUFV2; Atp5g2; APBB1; PPP3R1; CYCS; NDUFS3; CASP8; BAD
    Cardiac muscle contraction MYH15; MYL2; COX7A3; UQCRB; CACNA2D1; VMHCL; TPM4B; COX5B; UQCR10; COX7A2L
    Electron Transport Chain COX11; SLC25A27; NDUFC2-KCTD14; ATP5L; COX7C; COX4I1; COX8A; COX6C; NDUFS7; COX6A2
    Gene Expression U2AF2; TDRD1; ZNF221; ZNF710; DHX9; HNRNPR; ZNF215; IGF2BP3; ZNF671; GTF3C3
    Generic Transcription Pathway MED31; SKIB; ZKSCAN3; SKILB; ZNF398; ZNF550; ZNF157; ZNF266; ZNF257; RARG
    Huntingtons disease COX8A; NDUFA4; TBPL1; PPARG; BAX; POLR2A; HDAC2; HTT; NDUFB10; NRF1
    Metabolic pathways ENO3; TSTA3; ACSM3; PTGES3A; GLS; AKR1B7; PLA2G2E; ACSS2L; UQCRFS1; AK4
    Metabolism GPHNA; CYP2K8; TACO1; IP6K3; Sult2a6; PTPMT1; SLC35D2; SULT1B1; OAZ1; COX14

    COX6A1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6A1 itself. We selected most functions COX6A1 had, and list some proteins which have the same functions with COX6A1. You can find most of the proteins on our site.

    Function Related Protein
    cytochrome-c oxidase activity COX5B; COX5AA; COX6A1; COX8C; COX11; COX8A; COX7B2; COX7A2; COX15; COX6A2

    COX6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6A1.

    GRB2; HTT; CLPP

    HUNTSMAN, MM; ISACKSON, PJ; et al. LAMINA-SPECIFIC EXPRESSION AND ACTIVITY-DEPENDENT REGULATION OF 7 GABA(A) RECEPTOR SUBUNIT MESSENGER-RNAS IN MONKEY VISUAL-CORTEX. JOURNAL OF NEUROSCIENCE 14:2236-2259(1994).

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