crebl2
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  • Official Full Name
  • cAMP responsive element binding protein-like 2
  • Background
  • cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
  • Synonyms
  • CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; cAMP responsive element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding protein 1
Cat.#:CREBL2-1854HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CREBL2 Protein, GST-tagged
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Cat.#:CREBL2-079HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CREBL2 Protein, HIS-tagged
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Cat.#:CREBL2-3894MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CREBL2 Protein
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Cat.#:CREBL2-1593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CREBL2 Protein
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Cat.#:CREBL2-1023RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CREBL2 Protein, His-tagged
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Cat.#:CREBL2-5373CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CREBL2
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Cat.#:CREBL2-805ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CREBL2
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Cat.#:CREBL2-398HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CREBL2 cell lysate
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Protein Function

CREBL2 has several biochemical functions, for example, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREBL2 itself. We selected most functions CREBL2 had, and list some proteins which have the same functions with CREBL2. You can find most of the proteins on our site.
Function
Related Protein
Function sequence-specific DNA binding
Related Protein GRHL2A; LBX1; MAF; TFAP2A; VENT; MIXL1; HOXA3A; IRX4A; HOXA9B; PRDM5
Function transcription factor activity, sequence-specific DNA binding
Related Protein TBX10; LHX1A; SPZ1; HOXB8A; TCEAL1; GTF2H3; ATF7; HSF2; SOX7; SLC2A4RG

Interacting Protein

CREBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREBL2.
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