CREBL2
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Official Full Name
cAMP responsive element binding protein-like 2
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Overview
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. -
Synonyms
CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; cAMP responsive element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- HIS
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CREBL2 involved in several pathways and played different roles in them. We selected most pathways CREBL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CREBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CREBL2 has several biochemical functions, for example, sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREBL2 itself. We selected most functions CREBL2 had, and list some proteins which have the same functions with CREBL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | ZBTB14;E2F1;DMRTA2;RORCB;TRP63;ZSCAN4;MAFGB;ALX3;NR2F6B |
| transcription factor activity, sequence-specific DNA binding | CREB3;FOXO3A;TGIF2;ESRRGB;OTX1B;HOXA4;HOXB6;ZNF691;ZFP11 |
CREBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREBL2.
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