Recombinant Human CREBL2 Protein, GST-tagged

• Cat.No.: CREBL2-1854H
• Product Overview: Human CREBL2 full-length ORF ( NP_001301.1, 1 a.a. - 120 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 40.2 kDa
• AA Sequence: MDDSKVVGGKVKKPGKRGRKPAKID LKAKLERSRQSARECRARKKLRYQY LEELVSSRERAICALREELEMYKQW CMAMDQGKIPSEIKALLTGEEQNKS QQNSSRHTKAGKTDANSNSW
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CREBL2 cAMP responsive element binding protein-like 2 [ Homo sapiens ]
• Official Symbol: CREBL2
• Synonyms: CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; MHBs-binding protein 1; MGC117311; MGC138362
• Gene ID: 1389
• mRNA Refseq: NM_001310
• Protein Refseq: NP_001301
• MIM: 603476
• UniProt ID: O60519