Recombinant Human CREBL2 Protein, HIS-tagged

• Cat.No.: CREBL2-079H
• Product Overview: Recombinant Human CREBL2 fused with His tag at N-termina was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 13.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CREBL2 cAMP responsive element binding protein-like 2 [ Homo sapiens ]
• Official Symbol: CREBL2
• Synonyms: CREBL2; cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; MHBs-binding protein 1; MGC117311; MGC138362
• Gene ID: 1389
• mRNA Refseq: NM_001310
• Protein Refseq: NP_001301
• MIM: 603476
• UniProt ID: O60519