CRYM
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Official Full Name
crystallin, mu
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Overview
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
CRYM; crystallin, mu; thiomorpholine-carboxylate dehydrogenase; DFNA40; ketimine reductase; mu-crystallin homolog; NADP-regulated thyroid-hormone binding protein; THBP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CRYM involved in several pathways and played different roles in them. We selected most pathways CRYM participated on our site, such as Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, Lysine catabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ACMSD;FTCD;AMDHD1;PCBD1;IDO2;AFMID;CRYM;SLC25A21;UROC1 |
| Lysine catabolism | DLST;SLC25A21;CRYM |
| Metabolism | AZIN1A;AKR1C21;GPHN;HPSE;NQO1;CHST9;BCHE;CERS5;SULT1ST5 |
| Metabolism of amino acids and derivatives | OAZ2B;SLC6A7;SAT1B;PCBD1;HIBADH;AZIN1B;DAO1;CKMT1B;SLC25A15B |
CRYM has several biochemical functions, for example, NADP binding, hormone binding, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYM itself. We selected most functions CRYM had, and list some proteins which have the same functions with CRYM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADP binding | FMO2;POR;NOX1;FMO1;H6PD;FMO3;MIOX;CRYZL1;HMGCRA |
| hormone binding | AMHR2;UCN2;LRP2;GPR30;ADIPOR1A;TTR;ADIPOR2;ADIPOR1B;MC1R |
| oxidoreductase activity | FAM84B;IMPDH1A;NDOR1;CYP3C1L2;NOS2A;DHRS13A.3;RETSAT;CYP3A25;CYP2C19 |
| protein homodimerization activity | PEX7;ATG7;IKZF4;GRIK2;CUBN;SHMT1;NTRK2;HPGD;BNIP3 |
| thiomorpholine-carboxylate dehydrogenase activity | |
| thyroid hormone binding | ALDH1A3;CRYM;THRA;THRB;CTSH |
| transcription corepressor activity | NR1H4;CBFA2T3;DRAP1;E4F1;SNW1;SKOR2;HAND1;TAF9B;YAF2 |
CRYM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYM here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYM.
Atp6v1a; Ywhae; Dlg4
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