crym
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  • Official Full Name
  • crystallin, mu
  • Background
  • Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • CRYM; crystallin, mu; thiomorpholine-carboxylate dehydrogenase; DFNA40; ketimine reductase; mu-crystallin homolog; NADP-regulated thyroid-hormone binding protein; THBP
Cat.#:CRYM-1945HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CRYM Protein, GST-tagged
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Cat.#:CRYM-11608HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRYM, GST-tagged
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Cat.#:CRYM-30256THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRYM, His-tagged
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Cat.#:CRYM-3951MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CRYM Protein
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Cat.#:CRYM-1623RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRYM Protein
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Cat.#:CRYM-423CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CRYM Protein, His-tagged
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Cat.#:CRYM-1047RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CRYM Protein, His-tagged
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Cat.#:CRYM-5158ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CRYM
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Cat.#:CRYM-2493HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Crystallin, Mu, His-tagged
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Cat.#:CRYM-7254HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRYM 293 Cell Lysate
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Cat.#:CBCRY14Tag:
Source (Host):E. coliSpecies:
Product nameMu-crystallin homolog
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Involved Pathway

CRYM involved in several pathways and played different roles in them. We selected most pathways CRYM participated on our site, such as Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, Lysine catabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYM were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
PCBD1; UROC1; AMDHD1; DLST; FTCD; SLC25A21; IDO2; CRYM; AFMID; ACMSD
Lysine catabolism
DLST; SLC25A21; CRYM
Metabolism
GC; AK7; ADHFE1; FMODA; SLC25A1A; GPHNA; COX7C; ACY3.1; AFMID; BCHE
Metabolism of amino acids and derivatives
DBH; NQO1; CKB; TPH2; AMDHD1; SLC25A21; SLC25A15A; NAGS; ALDH9A1A.2; CKMT2

Protein Function

CRYM has several biochemical functions, for example, NADP binding, hormone binding, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYM itself. We selected most functions CRYM had, and list some proteins which have the same functions with CRYM. You can find most of the proteins on our site.
Function
Related Protein
Function NADP binding
Related Protein HMGCRA; NOX1; CRYZL1; G6PD; NOS2; MIOX; GAPDHS; MTRR; ASPDH; DHFRL1
Function hormone binding
Related Protein UCN2; ADIPOR1B; NPR2; CALR; MTNR1A; TTR; GPR30; MC1R; NPR3; MC5R
Function oxidoreductase activity
Related Protein DHRS7CA; GFOD1; KDM1A; CYP1A2; DCT; HSD17B12B; QDPRA; LOXL2B; HSD11B1LA; RDH12L
Function protein homodimerization activity
Related Protein CD2; UXS1; KIF20B; Fzd4; PAFAH1B1; PLD6; UGT1A7; ADSSL1; NTRK2; XDH
Function thiomorpholine-carboxylate dehydrogenase activity
Related Protein CRYM
Function thyroid hormone binding
Related Protein THRB; CRYM; THRA; ALDH1A3; CTSH
Function transcription corepressor activity
Related Protein DR1; SNW1; NR0B2; CDX2; NFKBIL2; TDP2; CSDA; ZNF593; GPS2; LHX1A

Interacting Protein

CRYM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYM here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYM.
Atp6v1a; Ywhae; Dlg4