csnk1a1
Share
  • Official Full Name
  • casein kinase 1, alpha 1
  • Background
  • Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
  • Synonyms
  • CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975
Cat.#:CSNK1A1-1986HTag:GST|His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human CSNK1A1 Protein, GST-His-tagged
+Inquiry
Cat.#:CSNK1A1-1988HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CSNK1A1 Protein, GST-tagged
+Inquiry
Cat.#:CSNK1A1-741HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Casein Kinase 1, Alpha 1, GST-His
+Inquiry
Cat.#:CSNK1A1-26814THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CSNK1A1
+Inquiry
Cat.#:CSNK1A1-5114HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSNK1A1, His-tagged
+Inquiry
Cat.#:CSNK1A1-513HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human casein kinase 1, alpha 1, His-tagged
+Inquiry
Cat.#:CSNK1A1-677HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Casein Kinase 1, Alpha 1, GST-tagged
+Inquiry
Cat.#:CSNK1A1-740HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CSNK1A1 protein, His & T7-tagged
+Inquiry
Cat.#:CSNK1A1-964HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSNK1A1, GST tagged
+Inquiry
Cat.#:CSNK1A1-1632RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CSNK1A1 Protein
+Inquiry
Cat.#:Csnk1a1-741RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Csnk1a1 protein, His & T7-tagged
+Inquiry
Cat.#:CSNK1A1-1058RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CSNK1A1 Protein, His-tagged
+Inquiry
Cat.#:CSNK1A1-6610CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CSNK1A1
+Inquiry
Cat.#:CSNK1A1-3069ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CSNK1A1
+Inquiry
Cat.#:CSNK1A1-617HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CSNK1A1 cell lysate
+Inquiry

Involved Pathway

CSNK1A1 involved in several pathways and played different roles in them. We selected most pathways CSNK1A1 participated on our site, such as AMER1 mutants destabilize the destruction complex, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSNK1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMER1 mutants destabilize the destruction complex
CSNK1A1
APC truncation mutants have impaired AXIN binding
CSNK1A1
AXIN missense mutants destabilize the destruction complex
CSNK1A1
AXIN mutants destabilize the destruction complex, activating WNT signaling
CSNK1A1
Activation of SMO
EVC2; CDON; EFCAB7; BOC; GAS8; KIF3A; IQCE; CSNK1A1; ADRBK1; EVC
Beta-catenin phosphorylation cascade
FAM123B; CSNK1A1
Canonical Wnt signaling pathway
KLHL12; CSNK1D; DVL2; DVL3; CSNK1A1; CSNK1E; DVL1
Degradation of GLI2 by the proteasome
CSNK1A1

Protein Function

CSNK1A1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSNK1A1 itself. We selected most functions CSNK1A1 had, and list some proteins which have the same functions with CSNK1A1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KHK; NVL; NETO2; MYO9B; ERCC3; ATP2A1L; UBE2D1; PTK2AA; TRIT1; ABCB3L1
Function protein binding
Related Protein TCTE3; PRKAA2; STON2; RBMY1B; ALPI; IFT172; MAP2K7; PIK3R4; GDF7; TACC3
Function protein kinase activity
Related Protein MAP3K12; GM4922; AURKA; RPS6KB1; CAMK2D2; AKT2L; RAF1; ERBB3B; HIPK3B; PRKAG1
Function protein serine/threonine kinase activity
Related Protein ACVR2B; VRK1; MAPKAPK2; SBK3; DAPK1; MAPK11; TTN; PAK6; SNRKB; LRRK2

Interacting Protein

CSNK1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSNK1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSNK1A1.
RIPK1; MDM4; q63629_rat; SEC16A; AXIN1; FAM83H; MDM2

CSNK1A1 Related Articles

Juhasz, K; Zvara, A; et al. Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells. IMMUNOLOGY LETTERS 152:55-64(2013).
Chiarini, A; Armato, U; et al. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. PROTEOMICS 9:1850-1860(2009).