ctbp1
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  • Official Full Name
  • C-terminal binding protein 1
  • Background
  • CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene act
  • Synonyms
  • CTBP1; C-terminal binding protein 1; C-terminal-binding protein 1; BARS; brefeldin A ribosylated substrate; brefeldin A-ribosylated substrate; MGC104684
Cat.#:CTBP1-2053HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTBP1 Protein, GST-tagged
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Cat.#:CTBP1-640HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTBP1 Protein, His-tagged
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Cat.#:CTBP1-26435THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTBP1
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Cat.#:CTBP1-1648RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTBP1 Protein
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Cat.#:CTBP1-1073RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTBP1 Protein, His-tagged
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Cat.#:CTBP1-2105CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTBP1
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Cat.#:CTBP1-9235ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTBP1
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Cat.#:CTBP1-2027HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C-terminal Binding Protein 1
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Cat.#:CTBP1-7215HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTBP1 293 Cell Lysate
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Cat.#:CTBP1-7216HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CTBP1 293 Cell Lysate
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Involved Pathway

CTBP1 involved in several pathways and played different roles in them. We selected most pathways CTBP1 participated on our site, such as Chronic myeloid leukemia, Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chronic myeloid leukemia
PIK3R1; CRKL; CCND1; HRAS; AKT1; PIK3CA; MECOM; MDM2; BAD; CDK6
Deactivation of the beta-catenin transactivating complex
SOX9A; SRY; TLE1; SOX9B; CBY1; SOX13; BCL9L; PYGO1; SOX4A; TLE2
Degradation of beta-catenin by the destruction complex
TLE1; TLE3; FAM123B; CTBP1; TLE3B; TLE4; AES; CTBP2; TLE2
Disease
HEY1; CTBP2; HDAC6; AP1S1; LRRFIP1; BANF1; AP1G1; HMGA1; CCDC167; RPL35
Diseases of signal transduction
TRAT1; TNKS2; LRRFIP1; TTR; HEY2; JAG2; TNKS; RLBP1; CPSF6; FKBP1A
Notch Signaling Pathway
HDAC2; DLL1; CIR1; EP300; DVL1B; DLK1; NCSTN; HER15.1; DTX1; NOTCH1B
Notch-mediated HES/HEY network
TLE1; GATA1; MYB; RCAN1; HES6; YY1; CTBP1; BGLAP; HEY1; GATA6

Protein Function

CTBP1 has several biochemical functions, for example, NAD binding, NADH binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP1 itself. We selected most functions CTBP1 had, and list some proteins which have the same functions with CTBP1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein MDH1; NDUFS2; LDHB; CTBP2L; IDH3A; AOX1; HSD3B5; HSD3B4; IDH1; HADHA
Function NADH binding
Related Protein CTBP2A; QDPR; CTBP2; CTBP1
Function RNA polymerase II transcription corepressor activity
Related Protein TBX15; RERE; TCERG1; SIN3AA; HDGF; SOX3; BEND6; UXT; TFAP2B; RBBP8
Function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Related Protein LDHBA; HMGCRB; CTBP2L; UEVLD; SDR42E1; AKR1B15; GPD1C; GPD1; CTBP1; MDH1B
Function protein C-terminus binding
Related Protein ATP1B1; TAX1BP3; SDC1; TOP2A; YWHAQ; HESX1; NEIL1; MAP2K1; YEATS4; BAIAP2
Function protein binding
Related Protein RICTOR; PDGFRA; WEE1; ZNF41; RNH1; BPIFA2; IL6ST; LITAF; CHRM3; FAM86A
Function protein domain specific binding
Related Protein GUSB; HMGB2; MTOR; YWHAG; NCK1; HIST1H4N; VAPA; MPP5; NDE1; MRPL17
Function protein homodimerization activity
Related Protein ABCG1; ACTN4; CCDC88A; SNX2; APOA2; SH3GLB1; FLNA; TG; PYCARD; AXIN1
Function repressing transcription factor binding
Related Protein MAGEA2; HDAC9; HDAC4; DDX20; CTNNB1; RUNX2; NOC2L; SKI; HHEX; TBP
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXB6; TRP53; SCML2; ZHX2; NFATC2; TFAM; HIVEP2; RORAA; MLXIPL; FOS
Function transcription factor binding
Related Protein NBN; LEF1; PPP1R13B; POU1F1; PBX1; ESRRB; TRAPPC2; GATA2; HDAC7; SRF

Interacting Protein

CTBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP1.
HIC1; ZNF366; e1a_ade05; RBBP8; CTBP2; EBNA6; KLF4