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CTBP1

  • Official Full Name

    C-terminal binding protein 1

  • Overview

    CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene act
  • Synonyms

    CTBP1; C-terminal binding protein 1; C-terminal-binding protein 1; BARS; brefeldin A ribosylated substrate; brefeldin A-ribosylated substrate; MGC104684;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTBP1-2053H Recombinant Human CTBP1 Protein, GST-tagged Wheat Germ GST
Human CTBP1-26435TH Recombinant Human CTBP1 E.coli N/A 440 amino acids
Human CTBP1-2027H Recombinant Human C-terminal Binding Protein 1 E.coli N/A
Human CTBP1-7216HCL Recombinant Human CTBP1 293 Cell Lysate HEK293 N/A
Human CTBP1-7215HCL Recombinant Human CTBP1 293 Cell Lysate HEK293 N/A
Human CTBP1-6132H Recombinant Human CTBP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTBP1-640H Recombinant Human CTBP1 Protein, His-tagged E.coli His Met1~Phe250
Human CTBP1-2267HF Recombinant Full Length Human CTBP1 Protein, GST-tagged In Vitro Cell Free System GST 429 amino acids
Human CTBP1-448HFL Recombinant Full Length Human CTBP1 Protein, C-Flag-tagged Mammalian cells Flag
Human CTBP1-3399H Recombinant Human CTBP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTBP1-678H Recombinant Human CTBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CTBP1-678H-B Recombinant Human CTBP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ctbp1-2351M Recombinant Mouse Ctbp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CTBP1-1648R Recombinant Rat CTBP1 Protein Mammalian Cell His
Rat CTBP1-1307R Recombinant Rat CTBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTBP1-1307R-B Recombinant Rat CTBP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTBP1-1073R Recombinant Rhesus monkey CTBP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTBP1-898R-B Recombinant Rhesus Macaque CTBP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTBP1-898R Recombinant Rhesus Macaque CTBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CTBP1-9235Z Recombinant Zebrafish CTBP1 Mammalian Cell His
Chicken CTBP1-2105C Recombinant Chicken CTBP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTBP1 Related Signal Pathway

CTBP1 involved in several pathways and played different roles in them. We selected most pathways CTBP1 participated on our site, such as Chronic myeloid leukemia, Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chronic myeloid leukemiaCBLC;CDK6;TGFB1;MAPK1;SOS1;SHC1;MECOM;PIK3CA;STAT5B
Deactivation of the beta-catenin transactivating complexPYGO1;TLE1;TLE2;SOX7;PYGO2;CBY1;TLE4;SRY;SOX13
Degradation of beta-catenin by the destruction complexCTBP2;CTBP1;AES;TLE1;TLE3B;TLE2;FAM123B;TLE3;TLE4
DiseaseCFTR;NMT1;gag;STX1B;TRAT1;OGN;TH1L;VPS37A;CHMP4B
Diseases of signal transductionRBP1;LRRFIP1;RLBP1;DERL2;FKBP1A;OPN1LW;HEYL;KREMEN1;HEY2
Notch Signaling PathwayDLB;RBPJ;DLL1;DLK1;HER6;MFAP2;MFNG;CIR1;RBPJB
Notch-mediated HES/HEY networkHES6;RCAN1;CTBP1;MYOD1;HEY1;GATA6;ASCL1;TLE1;GATA1

CTBP1 has several biochemical functions, for example, NAD binding, NADH binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP1 itself. We selected most functions CTBP1 had, and list some proteins which have the same functions with CTBP1. You can find most of the proteins on our site.

Function Related Protein
NAD bindingIDH3A;LDHA;GLYR1;GPD1B;GPD1A;ME1;DLD;GAPDHS;BDH2
NADH bindingCTBP2A;CTBP2;QDPR;CTBP1
RNA polymerase II transcription corepressor activityTXLNB;HDGF;SIN3A;TCERG1;URI1;N4BP2L2;ELANE;HEYL;HDAC1
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorMDH1AA;CTBP2L;AKR1B15;LDHBA;MDH1B;UEVLD;SDR42E1;TESCA;LDHBB
protein C-terminus bindingVTA1;MPDZ;XRCC6;PPM1A;CACNA1B;FOXN3;SCLT1;PEX16;EFHC1
protein bindingTNIK;USP6;ATP10A;TTC5;SUCLA2;MIF4GD;GP6;DROSHA;SMAD3A
protein domain specific bindingSORBS2;IST1;NFE2L2;ARFIP2;FOXA1;KCNN2;PPP3R1;PRKCI;SFN
protein homodimerization activityCADM4;NR0B2;BOKB;KCNK9;Trl;MAP3K13;ABCD3;HMGCL;CUL3
repressing transcription factor bindingNOC2L;HDAC4;MAGEA2;CTBP1;TBP;CTNNB1;TLE4;MYC;SRI
transcription factor activity, sequence-specific DNA bindingELF2B;ZNF789;ZNF518A;HSF5;SREBF1;IRF9;ZIK1;ZFP518A;ZHX3
transcription factor bindingMAFB;NEUROD1;TBL1X;MED6;FLNA;NCOA2;ATG7;GATA6;NFYC

CTBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP1.

HIC1; ZNF366; e1a_ade05; RBBP8; CTBP2; EBNA6; KLF4

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of CTBP1 in gene regulation? 02/19/2023

CTBP1 is a transcriptional co-repressor, regulating gene expression.

How do genetic variations in CTBP1 affect cellular differentiation? 09/15/2022

Genetic changes in CTBP1 affect cell development and differentiation.

How does CTBP1 interact with other transcriptional regulators? 02/11/2022

CTBP1 collaborates with transcription factors, influencing gene regulation.

What role does CTBP1 play in developmental processes? 10/07/2020

CTBP1 is involved in developmental processes and cell differentiation.

What potential therapeutic applications arise from targeting CTBP1 in diseases? 11/02/2019

Targeting CTBP1 could treat diseases with abnormal gene expression, including cancer.

How does CTBP1 contribute to transcriptional repression? 11/24/2018

It plays a key role in transcriptional repression, impacting gene activity.

What is the impact of altered CTBP1 activity on cancer progression? 04/08/2018

Altered CTBP1 activity is associated with cancer progression.

Customer Reviews (3)

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Reviews
10/12/2022

    Key to our research success, an integral research partner.

    02/15/2018

      Efficient and precise, a trusted research collaborator.

      04/03/2017

        Dependable partner, crucial for research integrity.

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