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CTBP2

  • Official Full Name

    C-terminal binding protein 2

  • Overview

    This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3 untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
  • Synonyms

    CTBP2; C-terminal binding protein 2; C-terminal-binding protein 2; ribeye; C terminal binding protein 2; CTBP2_HUMAN; OTTHUMP00000020699; OTTHUMP00000020700; OTTHUMP00000020701; OTTHUMP00000235908; OTTHUMP00000235909; OTTHUMP00000235910;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTBP2-2054H Recombinant Human CTBP2 Protein, GST-tagged Wheat Germ GST
Human CTBP2-28021TH Recombinant Human CTBP2 Wheat Germ N/A 445 amino acids
Human CTBP2-1451H Recombinant Human CTBP2 protein, His & T7-tagged E.coli His/T7 Met1~Leu252 (Accession # P56545)
Human CTBP2-417HCL Recombinant Human CTBP2 cell lysate N/A
Human CTBP2-2208HF Recombinant Full Length Human CTBP2 Protein, GST-tagged In Vitro Cell Free System GST 445 amino acids
Human CTBP2-4647H Recombinant Human CTBP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTBP2-3361H Recombinant Human CTBP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CTBP2-679H Recombinant Human CTBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CTBP2-679H-B Recombinant Human CTBP2 Protein Pre-coupled Magnetic Beads HEK293
Human CTBP2-6071H Recombinant Human CTBP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CTBP2-99HF Recombinant Full Length Human CTBP2 Protein In Vitro Cell Free System 445 amino acids
Human CTBP2-673HFL Recombinant Full Length Human CTBP2 Protein, C-Flag-tagged Mammalian cells Flag
Human CTBP2-1864H Recombinant Human CTBP2 Protein (Met1-Leu252), N-His tagged E.coli N-His Met1-Leu252
Mouse CTBP2-4010M Recombinant Mouse CTBP2 Protein Mammalian Cell His
Mouse Ctbp2-2352M Recombinant Mouse Ctbp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CTBP2-2040M-B Recombinant Mouse CTBP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse CTBP2-2040M Recombinant Mouse CTBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTBP2-1649R Recombinant Rat CTBP2 Protein Mammalian Cell His
Rat CTBP2-1308R Recombinant Rat CTBP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CTBP2-1308R-B Recombinant Rat CTBP2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTBP2 Related Articles

CTBP2 involved in several pathways and played different roles in them. We selected most pathways CTBP2 participated on our site, such as Chronic myeloid leukemia, Degradation of beta-catenin by the destruction complex, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chronic myeloid leukemiaPIK3CG;STAT5B;MAPK1;NFKB1;HDAC1;MDM2;BAD;HRAS;GRB2
Degradation of beta-catenin by the destruction complexTLE4;CTBP2;FAM123B;CTBP1;TLE2;AES;TLE3B;TLE1;TLE3
DiseaseDOCK2;CUX1;GYG1;OPN1LW;NPM1;CHMP4B;CCDC59;STRA6;SUPT4H1
Diseases of signal transductionFGFR1OP2;DERL2;HEY2;OS9;OPN1MW;TNKS;CDC37;TTR;CTBP2
Neural Crest DifferentiationCDH6;SOX10;MIA;ASCL1;TFAP2A;FOXD3;LHX2;CTBP2;TBX6
Notch Signaling PathwayMFNG;JAG1A;SNW1;PTCRA;DTX4;NOTCH2;ADAM17A;MYCBP;DTX3
Pathways in cancerPTEN;AXIN2;RARB;FGF19;LAMA5;BRCA2;PDGFB;WNT5A;VEGFA

CTBP2 has several biochemical functions, for example, NADH binding, chromatin binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP2 itself. We selected most functions CTBP2 had, and list some proteins which have the same functions with CTBP2. You can find most of the proteins on our site.

Function Related Protein
NADH bindingCTBP2;QDPR;CTBP1;CTBP2A
chromatin bindingLMO2;SIN3A;TDRD3;HMGB3;NIPBL;TTC5;SMAD2;JDP2;KDM1A
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorLDHBA;CTBP2L;SDR42E1;AKR1B15;HMGCRA;HMGCRB;CTBP2;FAM213B;MDH1B
protein bindingCD59;COPB1;RPS26;POLDIP3;SCAND1;NCAM1A;PFN2;GBP2;HPCAL1
protein homodimerization activityADRA2C;SMAGP;CD226;RENBP;NOG;UGT1A2;GRPEL1;SNRPC;FGFR1OP
retinoic acid receptor bindingHMGA1-RS1;PRAMEF1;HMGA1;MED1;AASS;ACTN4;PRAMEF10;CNOT1;LRIF1
transcription coactivator activityPML;MTF1;WNT3A;NR2F1;MED21;GMEB2;CITED1;TRIM32;CITED4
transcription corepressor activityTRIM22;EID1;ZHX3;ZBTB32;PROX1;E2F6;WWTR1;LOXL2;KCTD1

CTBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP2.

TGIF1; IKZF1; RAI2; CCNH; FOXP2

Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
Muller, B; Butz, E; et al. The Rod Pathway of the Microbat Retina Has Bistratified Rod Bipolar Cells and Tristratified AII Amacrine Cells. JOURNAL OF NEUROSCIENCE 33:1014-1023(2013).
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