CYP2A13 Protein, cytochrome P450, family 2, subfamily A, polypeptide 13

CYP2A13

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CYP2A13

Official Full Name cytochrome P450, family 2, subfamily A, polypeptide 13
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms CYP2A13; cytochrome P450, family 2, subfamily A, polypeptide 13; cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 13; cytochrome P450 2A13; CPAD; CYP2A; CYPIIA13; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13
    • Species :
    • Human
    • Source :
    • E.coli
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2A13-34H Recombinant Human CYP2A13 Protein E.coli
    Human CYP2A13-2256H Recombinant Human CYP2A13 Protein, GST-tagged Wheat Germ GST
    Human CYP2A13-433HCL Recombinant Human CYP2A13 cell lysate N/A

    CYP2A13 involved in several pathways and played different roles in them. We selected most pathways CYP2A13 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aflatoxin B1 metabolism CYP1A2; CYP2A13; FAM84B; CYP3A4; PRKRA
    Aflatoxin activation and detoxification DPEP2; CYP1A2; CYP3C4; DPEP1; CYP3C1; ACY3.1; CYP2A13; GGTLC1; CYP2Y3; PRKRA
    Biological oxidations SLC35B2; ADH1C; CYP2B6; ADH8B; GSTK1; CYP2J2; CYP17A1; CYP8B2; PRKRA; ADH4
    CYP2E1 reactions CYP2C19; CYP2F1; CYP2Y3; CYP2A7; CYP2A13; CYP2C8; CYP2D6; CYP2A6; CYP2B6; CYP2E1
    Chemical carcinogenesis EPHX1; GSTK1; UGT1A7C; ALDH3B2; CYP2C8; CYP2A13; UGT2A2; CYP3A5; CYP2C37; ALDH3B1
    Cytochrome P450 - arranged by substrate type CYP2J2; CYP8B2; CYP46A1; CYP1B1; CYP2AD2; CYP24A1; CYP2V1; FDX1L; CYP2S1; CYP2C8
    Fatty acids CYP2AD3; CYP2D6; CYP4B1; CYP2A7; CYP4A11; CYP2AD2; CYP2A13; CYP2AD6; CYP4F11; CYP4T8
    Metabolism RHAG; OAZ2; Alb; FABP11A; TPTE; TPMT.2; SLC46A1; GLTPA; ETFB; FA2H

    CYP2A13 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A13 itself. We selected most functions CYP2A13 had, and list some proteins which have the same functions with CYP2A13. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP2C37; CYP2A13; CYP2C39; CYP4F2; CYP2A7; CYP4F12; CYP2A6; CYP2AA12; CYP2S1; CYP2F1
    aromatase activity CYP1B1; CYP3A43; CYP2F1; CYP3A25; CYP2A12; CYP3A5; CYP2B19; CYP1D1; CYP2C9; CYP2D26
    heme binding PTGESL; BA1; GUCY1B3; HBG1; MPO; CYP2W1; IDO1; CYP3C1L2; CYP7A1; CYP4A12A
    iron ion binding CYP2C9; CYP2AA4; CYP26A1; LTF; CYP4B1; TMEM195; P4HA1A; HBBE2; ALOX12B; BA1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2X7; CYP1A; CYP2AA8; CYP2K19; CYP2AA1; CYP2B19; CYP2C37; CYP2AA9; CYP2K22; CYP2AA12
    oxygen binding TDO2; CYP2AA4; CYP2F1; CYP2Y3; CYP17A1; HBBE3; CYP2D10; CYP2B6; HBQ1; HBAD
    steroid hydroxylase activity CYP2P10; CYP46A1.3; CYP2C54; CYP2Y3; CYP2K17; CYP2E1; CYP2J2; CYP2A13; CYP2AD3; CYP2X7

    CYP2A13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A13.

    Liu, ZH; Li, L; et al. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo. DRUG METABOLISM AND DISPOSITION 43:208-216(2015).
    Chiang, HC; Wang, CK; et al. Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract. RESPIRATION 84:319-326(2012).

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