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CYP2C19

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 19

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
  • Synonyms

    CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19; cytochrome P450 2C19; CPCJ; P450IIC19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cyto;

  • Recombinant Proteins
  • Assay Kits
  • Cynomolgus
  • Human
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mamanlian cells
  • P.pastoris
  • Protein Conjugation
  • S.cerevisiae
  • Flag
  • His
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2C19-542H Active Recombinant Human CYP2C19 S.cerevisiae N/A
Human CYP2C19-541H Active Recombinant Human CYP2C19 E.coli N/A
Human CYP2C19-540H Active Recombinant Human CYP2C19 (I331V) E.coli N/A
Human CYP2C19-538H Recombinant Human CYP2C19, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP2C19-536H Recombinant Human CYP2C19 Insect Cell N/A
Human CYP2C19-16H Recombinant Human CYP2C19 protein, Active P.pastoris N/A
Human CYP2C19-33H Active Recombinant Human CYP2C19 Protein E.coli
Human CYP2C19-2793H Recombinant Human CYP2C19 protein, His&Myc-tagged E.coli His&Myc 26-490aa
Human CYP2C19-75H Active Recombinant Human CYP2C19 Protein E. coli
Human CYP2C19-2797H Recombinant Human CYP2C19 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Cys266-Glu281
Human CYP2C19-5425HFL Recombinant Full Length Human CYP2C19, Flag-tagged Mamanlian cells Flag
Cynomolgus CYP2C19-126C Active Recombinant Cynomolgus CYP2C19 Protein E. coli
Kit-2124 Cytochrome P450 2C19 Fluorometric Activity Assay Kit N/A
Kit-0908 CYP2C19 Blue Screening Kit N/A
Kit-2125 Cytochrome P450 2C19 Inhibitor Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2C19 Related Articles

CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP2C37;CYP2J5;GGTLC1;AKR1C3;GPX1;CYP2C50;GPX5;PTGIS;PLA2G16
Biological oxidationsADH8B;AS3MT;CYP4B1;NCOA2;CYP2A6;UGT1B3;CYP2U1;FAM84B;CYP2AD2
CYP2E1 reactionsCYP2A6;CYP2Y3;CYP2D6;CYP2S1;CYP2C8;CYP2C9;CYP2A13;CYP2C19;CYP2F1
Chemical carcinogenesisGSTT2;Nat3;CYP3A4;CYP2C19;SULT1A1;CYP2C37;UGT1A2;CYP2C70;CYP3A25
Cytochrome P450 - arranged by substrate typeCYP3A7-CYP3AP1;FAM84B;CYP3A4;CYP4F12;CYP19A1;CYP4A11;CYP2K22;CYP51A1;CYP2A13
Drug metabolism - cytochrome P450ADH1B;CYP2A6;CYP2D6;ADH4;CYP2E1;CYP3A5;CYP2C8;GSTO2;ADH1A
Linoleic acid metabolismCYP2J6;PLA2G4AA;CYP2C38;CYP2P10;CYP2C70;DHRS13L1;CYP2C9;ALOX15;CYP2P8
Metabolic pathwaysTPI1;INPP5KA;ASAH1;PTGES2;HPD;PIGU;NME2B.1;B3GALT2;GSS

CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.

Function Related Protein
(R)-limonene 6-monooxygenase activityCYP2C19;CYP2C8;CYP2C9
(S)-limonene 6-monooxygenase activityCYP2C9;CYP2C8;CYP2C19
(S)-limonene 7-monooxygenase activityCYP2C9;CYP2C8;CYP2C19
arachidonic acid epoxygenase activityCYP2A13;CYP2B6;CYP2C55;CYP2C18;CYP4A10;CYP2D10;CYP2P8;CYP2C19;CYP2B19
enzyme bindingCAD;STUB1;UGT1A6A;MDM4;APOA5;POR;GOT2;GBP1;CYP1A1
heme bindingPGRMC1;CYP3A7;EIF2AK1;CYP3A4;HBA2;CYP2X7;CYP2D26;CYP2B6;NENF
iron ion bindingTPH1A;CYP4V7;HBAD;FDX1;FAXDC2;ACO2;CYGB1;PDF;CYP2P7
monooxygenase activityCYP2C37;CYP2D9;CYP4F14;CYP3C4;CYP2AA6;CYP1A4;CYP2K19;MOXD2;CYP2F1
oxidoreductase activityBCO2L;ENOX1;ETFA;DIO3A;CYP2AD6;AKR1C21;MDH1AA;PHF2;CYP2D6
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2K22;CYP2AA6;CYP2A4;CYP1B1;CYP2AD3;CYP2K6;CYP2A12;CYP2F2;CYP2P9
oxygen bindingHBBE2;CYP2P10;CYP2AA4;CYP2A12;HBA-X;CYP2F1;HBA1;CYP2K19;CYP2K18
steroid hydroxylase activityCYP2AA9;CYP2K17;CYP27A1;CYP2C9;CYP2E1;CYP2D9;CYP2P9;CYP21A2;CYP2K18

CYP2C19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C19.

Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
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