cyp2c19
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 19
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
  • Synonyms
  • CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19; cytochrome P450 2C19; CPCJ; P450IIC19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cyto
Cat.#:CYP2C19-16HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human CYP2C19 protein, Active
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Cat.#:CYP2C19-536HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2C19
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Cat.#:CYP2C19-538HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2C19, MYC/DDK-tagged
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Cat.#:CYP2C19-540HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C19 (I331V)
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Cat.#:CYP2C19-541HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C19
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Cat.#:CYP2C19-542HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human CYP2C19
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Cat.#:Kit-2124Tag:
Source (Host):Species:
Product nameCytochrome P450 2C19 Fluorometric Activity Assay Kit
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Cat.#:Kit-2125Tag:
Source (Host):Species:
Product nameCytochrome P450 2C19 Inhibitor Screening Kit
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Cat.#:Kit-0908Tag:
Source (Host):Species:
Product nameCYP2C19 Blue Screening Kit
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Involved Pathway

CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
PTGS2; PTGDSB; CYP4A11; PLA2G2E; CYP4F22; CYP4A14; CYP2C70; GPX6; CYP2C19; PLA2G6
Biological oxidations
CYP2D6; ABHD14B; MTRR; CYP24A1; CYP46A1; CYP7A1; SULT1C2; CYP2AD3; CYP2J2; CYP1A1
CYP2E1 reactions
CYP2D6; CYP2E1; CYP2Y3; CYP2C19; CYP2B6; CYP2A6; CYP2S1; CYP2C9; CYP2C8; CYP2A7
Chemical carcinogenesis
UGT1A6; MGST1; ADH1B; UGT2B7; GSTA3; CYP2A13; GSTA5; SULT1A1; CBR1; CYP3A7
Cytochrome P450 - arranged by substrate type
CYP3A7; CYP3A5; CYP27B1; CYP4F12; CYP2C8; CYP2S1; FDX1L; CYP11B2; CYP2W1; CYP2AD3
Drug metabolism - cytochrome P450
CYP2E1; CYP2C8; ADH2-2; ADH7; ADH5; GSTK1; CYP2C19; CYP2D6; ADH1B; GSTO2
Linoleic acid metabolism
ALOX15; PLA2G4AA; CYP2C8; CYP2P8; PLA2G4A; PLA2G5; CYP2J2; CYP2P9; PLA2G1B; CYP2C55
Metabolic pathways
HMGCL; HOGA1; NANSA; RPIA; ALDH1A2; CKMT1; INPP5J; FOLH1; RDH12; CSGALNACT2

Protein Function

CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.
Function
Related Protein
Function (R)-limonene 6-monooxygenase activity
Related Protein CYP2C9; CYP2C8; CYP2C19
Function (S)-limonene 6-monooxygenase activity
Related Protein CYP2C8; CYP2C9; CYP2C19
Function (S)-limonene 7-monooxygenase activity
Related Protein CYP2C19; CYP2C8; CYP2C9
Function arachidonic acid epoxygenase activity
Related Protein CYP2AA1; CYP2AA12; CYP2AA7; CYP2C9; CYP2C54; CYP2AA8; CYP2J6; CYP2C19; CYP2A6; CYP2S1
Function enzyme binding
Related Protein CRB2; SCARB2; MST1R; UGT1A6; CREB1; TMBIM6; BTG1; PTEN; CYP2C8; SCNM1-PS
Function heme binding
Related Protein CYP2D26; CYP2AA7; CYP2X7; HBG1; CYP1A; CYP2P6; HEBP1; CYP7A1A; CYP3A43; HBG2
Function iron ion binding
Related Protein HBAE3; CYP4X1; CYP2C54; CYP2AA12; CYP4A10; CYP2K17; CYP46A1; CYP4V2; CYP2S1; CYP2C18
Function monooxygenase activity
Related Protein CYP26C1; CYP1A1; CYP4A12A; CYP46A1.1; CYP2E1; FOXRED2; CYP2J6; CYP2X8; CYP4F18; CYP4F14
Function oxidoreductase activity
Related Protein ALDH3A2A; HPDB; CYP1A2; CYP2V1; AKR1CL1; ALDH9A1B; CYP3C4; AKR7A5; CYP21A1; ACOXL
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2X8; CYP2B19; CYP2P10; CYP2C54; CYP2A6; CYP2U1; CYP2E1; CYP2C50; CYP2C38; CYP2D26
Function oxygen binding
Related Protein Adgb; CYP2AD2; CYP2K17; CYP2B19; CYGB2; CYP2V1; HBAE1; HBAA; CYP2C9; CYP2J5
Function steroid hydroxylase activity
Related Protein CYP2X8; CYP2AA4; CYP2J2; CYP2R1; FAM84B; CYP2AD2; CYP2X7; CYP2V1; CYP2X9; CYP2K6

CYP2C19 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).