| Official Full Name | cytochrome P450, family 2, subfamily C, polypeptide 19 |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| Synonyms | CYP2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; CYP2C, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 19; cytochrome P450 2C19; CPCJ; P450IIC19; CYPIIC17; CYPIIC19; cytochrome P450-11A; cytochrome P450-254C; cyto |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
CYP2C19 involved in several pathways and played different roles in them. We selected most pathways CYP2C19 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PTGS1; CYP2C45; GPX6; PLA2G2D; CYP2P6; CYP2AD3; CYP4A14; ALOX12; PLA2G4C; PLB1 |
| Biological oxidations | GGT6; ACY3.1; UGT1B2; CYP2C19; CYP2N13; CYP2F1; SULT2ST2; CYP2C8; CYP26A1; CYP2K6 |
| CYP2E1 reactions | CYP2S1; CYP2A7; CYP2D6; CYP2Y3; CYP2A13; CYP2C9; CYP2F1; CYP2B6; CYP2E1; CYP2C8 |
| Chemical carcinogenesis | CYP2C50; UGT1A6B; CYP2C39; GSTA5; ADH1C; SULT1A1; CYP2C38; ADH1; CYP3A4; ADH2-2 |
| Cytochrome P450 - arranged by substrate type | CYP2D6; CYP2W1; CYP8B2; CYP2AD6; CYP4B1; CYP2A6; CYP2K18; CYP19A1; CYP2F1; CYP2K16 |
| Drug metabolism - cytochrome P450 | ADH1C; CYP2B6; ADH1B; CYP2C8; GSTO2; CYP2C9; CYP2D6; GSTK1; ADH2-2; CYP3A5 |
| Linoleic acid metabolism | PLA2G4A; PLA2G2F; CYP2C38; CYP2C55; CYP2C8; PLB1; CYP2P9; PLA2G2D; PLA2G12A; PLA2G10 |
| Metabolic pathways | FUT9A; DAK; PLCB2; NDUFB2; GMPPA; PLB1; ENO1A; PSPH; RRM1; HDC |
CYP2C19 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C19 itself. We selected most functions CYP2C19 had, and list some proteins which have the same functions with CYP2C19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| (R)-limonene 6-monooxygenase activity | CYP2C9; CYP2C19; CYP2C8 |
| (S)-limonene 6-monooxygenase activity | CYP2C19; CYP2C9; CYP2C8 |
| (S)-limonene 7-monooxygenase activity | CYP2C9; CYP2C8; CYP2C19 |
| arachidonic acid epoxygenase activity | CYP2C8; CYP2S1; CYP2C50; CYP2F1; CYP2C19; CYP2A6; CYP2AA3; CYP2AA12; CYP2D6; CYP2D9 |
| enzyme binding | HMGA1-RS1; PTPLAD1; JUND; NFKBIA; PARK2; PAWR; PRKCE; C6orf211; PLCB1; HIST1H2AG |
| heme binding | CYP3C1L2; CYP27A1; CYP4F14; SUOX; CYP2AD6; CYGB; CYP2C70; CYP2C9; GUCY1B3; CYP1D1 |
| iron ion binding | CYP2AA2; CYGB1; CYP8B3; CYP2X8; CYP2K6; CYP2AA12; CYP1A2; CYP2C9; CYP2F1; CYP19A1A |
| monooxygenase activity | CYP2D6; CYP4V7; CYP4V2; CYP4F22; CYP19A1A; CYP3A4; YWHAE2; COQ6; CYP2AA8; CYP2K19 |
| oxidoreductase activity | ERO1L; JMJD1C; AKR1E1; TDO2A; CYP4A10; CYP2C39; CBR2; PYROXD1; PXDN; AKR7A5 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2P8; CYP2P7; CYP2P6; CYP2B19; CYP2K19; CYP2J2; CYP2E1; CYP2C38; CYP2AA6; CYP2A12 |
| oxygen binding | CYP2AA4; HBB-B2; CYP2P7; CYP2E1; HBAA; CYP2B6; BA1; HBZ; CYP2AD6; CYP2C8 |
| steroid hydroxylase activity | CYP2R1; CYP2J5; FAM84B; CYP2C8; CYP1A1; CYP2S1; CYP2AA2; CYP2U1; BRSK2; CYP2AD6 |
CYP2C19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C19 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C19.
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