cyp2e1
Share
  • Official Full Name
  • cytochrome P450, family 2, subfamily E, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;
Cat.#:CYP2E1-2265HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2E1 Protein, GST-tagged
+Inquiry
Cat.#:CYP2E1-2475HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1
+Inquiry
Cat.#:CYP2E1-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1 protein, His-tagged
+Inquiry
Cat.#:CYP2E1-450HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2E1
+Inquiry
Cat.#:CYP2E1-452HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2E1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:CYP2E1-547HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human CYP2E1
+Inquiry
Cat.#:CYP2E1-5702HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1 protein, His & GST-tagged
+Inquiry
Cat.#:CYP2E1-4191MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP2E1 Protein
+Inquiry
Cat.#:Cyp2e1-5703MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cyp2e1 protein, His-tagged
+Inquiry
Cat.#:CYP2E1-1738RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP2E1 Protein
+Inquiry
Cat.#:Cyp2e1-5704RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cyp2e1 protein, His-tagged
+Inquiry
Cat.#:CYP2E1-1154RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2E1 Protein, His-tagged
+Inquiry
Cat.#:CYP2E1-219HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human and Yeast
Product nameRecombinant Human CYP2E1and Yeast CYP-reductase
+Inquiry
Cat.#:CYP2E1-7111HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2E1 293 Cell Lysate
+Inquiry
Cat.#:Kit-0935Tag:
Source (Host):Species:
Product nameCYP2E1 Blue Screening Kit
+Inquiry

Involved Pathway

CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
ALOX12; PLA2G5; CYP2J6; PTGS2B; CYP2C55; GGT1; GGT1A; PTGES; PLA2G4A; CBR3
Biological oxidations
SULT2ST2; ADH4; SLC26A2; GLYATL2; CYP46A1; SLC35B2; ADH1A; CYP2Y3; CYP4B1; CYP1A2
CYP2E1 reactions
CYP2A7; CYP2B6; CYP2A6; CYP2C8; CYP2Y3; CYP2D6; CYP2C9; CYP2S1; CYP2A13; CYP2F1
Chemical carcinogenesis
UGT1A7C; MGST3; EPHX1; CYP2C55; ALDH3B2; ADH4; GSTM7; ADH1A; UGT1A7; ADH1C
Cytochrome P450 - arranged by substrate type
CYP24A1; CYP8B2; CYP2AD6; CYP21A2; CYP11B1; CYP4B1; CYP2C18; CYP2C9; CYP27A1; CYP2K18
Drug metabolism - cytochrome P450
GSTO2; ADH1A; ADH4; CYP2A6; CYP2C9; CYP2C8; ADH2-2; ADH7; ADH1B; CYP2B6
Fatty Acid Omega Oxidation
ADH6; ADH1A; CYP2E1; CYP2D6; ADH1C; CYP2A6; ADH4; CYP1A1; CYP4A11; ADH7
Folate-Alcohol and Cancer Pathway
ALDH1L1; CYP2E1

Protein Function

CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, enzyme binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2AD2; CYP2A12; CYP2A13; CYP4F18; CYP2E1; CYP2AA12; CYP2D6; CYP2F1; CYP2C8; CYP2C9
Function enzyme binding
Related Protein PICK1; SLC27A2; CAT; APBA3; PEX5; RPA3; FAM84B; DDX5; PHKG1; PAWR
Function heme binding
Related Protein CYP1B1; TDO2A; HBA2; HBB-BH1; CYP2S1; CYP2C37; HBB-Y; CYP3C1; CYP1A4; HBAA
Function iron ion binding
Related Protein CYP46A1; NDOR1; PHF2; HBD; TPH1; CYP2A6; HBA1; NOS1; PHF8; CYP1A4
Function monooxygenase activity
Related Protein CYP4V8; CYP2K16; CYP2B19; MICAL2; TH2; CYP4F22; CYP2AD3; CYP2X9; CYP2V1; FMO2
Function oxidoreductase activity
Related Protein CYP2AA1; GPX4A; PYCR1A; RTN4IP1; ETFDH; IMPDH1A; PRODH2; SPRA; PDHA1B; MSRB1A
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Related Protein CYP11C1; POR; CYP4F18; CYP11A1; CYP11B1; MTRR; CYP4F11; CYP11B2; MICAL2; CYP2E1
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2C9; CYP2C54; CYP2AA3; CYP2C70; CYP2K17; CYP2AD2; CYP2A13; CYP2K16; CYP2D6; CYP2K19
Function oxygen binding
Related Protein MB; HBG2; CYP2U1; CYP2F1; CYP2AA7; HBB-B2; HBBE1.1; CYP2A13; CYP17A1; CYP2AA9
Function steroid hydroxylase activity
Related Protein CH25H; CYP2AA1; CYP21A2; CYP2F1; CYP2P10; CYP2P7; CYP27A1; CYP2C50; FAM84B; CYP2B19

Interacting Protein

CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.
MAFG; CLU; PTN; ECHS1; RPL13A; GATM; NMI; ABCA5; AGXT2; LAMC3

CYP2E1 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Safari, S; Motavaf, M; et al. Hepatotoxicity of Halogenated Inhalational Anesthetics. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2014).