CYP2E1 Protein, cytochrome P450, family 2, subfamily E, polypeptide 1

CYP2E1

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CYP2E1

Official Full Name cytochrome P450, family 2, subfamily E, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Synonyms CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;
    • Species :
    • Human
    • Human and Yeast
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • S.cerevisiae
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2E1-220H Recombinant Human CYP2E1 Protein E.coli N/A
    Human CYP2E1-221H Recombinant Human CYP2E1 Protein E.coli N/A
    Mouse CYP2E1-1373M Recombinant Mouse CYP2E1 Protein (2-493 aa), His-tagged Yeast His
    Human CYP2E1-2265H Recombinant Human CYP2E1 Protein, GST-tagged Wheat Germ GST
    Human CYP2E1-2475H Recombinant Human CYP2E1 E.coli N/A
    Human CYP2E1-32H Recombinant Human CYP2E1 protein, His-tagged E.coli His
    Human CYP2E1-450H Recombinant Human CYP2E1 Insect Cell N/A
    Human CYP2E1-452H Recombinant Human CYP2E1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP2E1-547H Recombinant Human CYP2E1 S.cerevisiae N/A
    Human CYP2E1-5702H Recombinant Human CYP2E1 protein, His & GST-tagged E.coli His/GST
    Human CYP2E1-7111HCL Recombinant Human CYP2E1 293 Cell Lysate HEK293 N/A
    Mouse CYP2E1-4191M Recombinant Mouse CYP2E1 Protein Mammalian Cell His
    Mouse Cyp2e1-5703M Recombinant Mouse Cyp2e1 protein, His-tagged E.coli His
    Rat CYP2E1-1738R Recombinant Rat CYP2E1 Protein Mammalian Cell His
    Rat Cyp2e1-5704R Recombinant Rat Cyp2e1 protein, His-tagged E.coli His
    Rhesus Macaque CYP2E1-1154R Recombinant Rhesus monkey CYP2E1 Protein, His-tagged Mammalian Cell His
    Human and Yeast CYP2E1-219H Recombinant Human CYP2E1and Yeast CYP-reductase S.cerevisiae N/A
    Kit-0935 CYP2E1 Blue Screening Kit N/A

    CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism FAAH2A; CYP1B1; AKR1C3; HPGDS; CYP2AD6; GGT1; PLA2G5; CYP2C70; CYP1A2; CYP4F14
    Biological oxidations SLC35B2; CYP2K8; ADH1C; SULT1C2; CYP3A7-CYP3AP1; CYP11B1; NCOA2; ADH1B; CYP4F22; CYP4B1
    CYP2E1 reactions CYP2C9; CYP2C19; CYP2B6; CYP2E1; CYP2D6; CYP2S1; CYP2A6; CYP2C8; CYP2A13; CYP2F1
    Chemical carcinogenesis CBR1; GSTA2; PTGS2; GSTM4; CHRNA7; UGT2B7; CYP3A4; GSTM2; UGT1A3; AHA-1
    Cytochrome P450 - arranged by substrate type CYP2W1; CYP27B1; CYP2U1; CYP19A1; CYP4T8; CYP2R1; CYP2K22; CYP7A1; CYP2K17; CYP2K6
    Drug metabolism - cytochrome P450 CYP3A5; CYP2D6; ADH1A; ADH1C; ADH7; ADH2-2; ADH6; CYP2C19; GSTK1; GSTO2
    Fatty Acid Omega Oxidation CYP2D6; CYP2E1; CYP4A11; ADH7; ADH1A; CYP2A6; ADH6; ADH1C; ADH1B; ADH4
    Folate-Alcohol and Cancer Pathway CYP2E1; ALDH1L1

    CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, enzyme binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid epoxygenase activity CYP4F18; CYP2AD2; CYP2AA3; CYP2C55; CYP2C19; CYP2D9; CYP2J2; CYP2AA7; CYP2AD6; CYP2AA1
    enzyme binding PYCARD; MSH3; ESR2; ANK1; CLSTN2; IL6R; MLEC; PPP1R3D; RCOR1; CBX4
    heme binding Adgb; CYP3A7; PTGIS; CBSA; HBA-A2; CYP3A5; CYP21A2; HBAE3; AMBP; CYP2F2
    iron ion binding ALOX15B; CYP2A6; LEPREL1; FAXDC2; HBA2; CYP2AA1; PPEF2; CYP46A1.1; CYP2AA2; TMLHE
    monooxygenase activity CYP2C18; CYP2P6; YWHAQA; CYP4A12A; FOXRED2; CYP4A10; CYP2D9; CYP2C8; CYP51; CYP2AD3
    oxidoreductase activity GULO; AKR1B8; LOXL2A; DMGDH; CYP19A1A; ERO1LB; CYP4T8; APEX1; CYP2D6; CYP2AA9
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen CYP11C1; CYP11B2; CYP4F11; CYP4F18; CYP11A1; CYP4F2; MTRR; CYP11B1; COQ6; MICAL1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2V1; CYP2C8; CYP19A1; CYP2J2; CYP2N13; CYP2AA9; CYP2B19; CYP2A7; CYP2C19; CYP2K16
    oxygen binding CYP2K6; CYP2Y3; CYP2P9; CYP2D6; CYP2AA12; CYP19A1; CYP2P6; FAM84B; HBAE3; HBG2
    steroid hydroxylase activity CYP2K17; CYP2F2; CYP2Y3; CYP2C9; CH25H; CYP2K16; CYP46A1; CYP2C19; CYP2AD3; CYP2K18

    CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.

    MAFG; CLU; PTN; ECHS1; RPL13A; GATM; NMI; ABCA5; AGXT2; LAMC3

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Safari, S; Motavaf, M; et al. Hepatotoxicity of Halogenated Inhalational Anesthetics. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2014).

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