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CYP2E1

  • Official Full Name

    cytochrome P450, family 2, subfamily E, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
  • Synonyms

    CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human and Yeast
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • S.cerevisiae
  • Wheat Germ
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2E1-547H Active Recombinant Human CYP2E1 S.cerevisiae N/A
Human CYP2E1-5702H Recombinant Human CYP2E1 protein, His & GST-tagged E.coli His/GST Pro36~Val271
Human CYP2E1-450H Recombinant Human CYP2E1 Insect Cell N/A
Human CYP2E1-32H Recombinant Human CYP2E1 protein, His-tagged E.coli His
Human CYP2E1-452H Recombinant Human CYP2E1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP2E1-2265H Recombinant Human CYP2E1 Protein, GST-tagged Wheat Germ GST
Human CYP2E1-2475H Recombinant Human CYP2E1 E.coli N/A
Human CYP2E1-7111HCL Recombinant Human CYP2E1 293 Cell Lysate HEK293 N/A
Human CYP2E1-890H Recombinant Human CYP2E1 Protein, His-tagged E.coli N-His Pro36-Val271
Human CYP2E1-221H Active Recombinant Human CYP2E1 Protein E.coli N/A
Human CYP2E1-79H Active Recombinant Human CYP2E1 Protein E. coli
Human CYP2E1-0006H Recombinant Human CYP2E1 Protein (L32-S493), His tagged E.coli His L32-S493
Human CYP2E1-2388HF Recombinant Full Length Human CYP2E1 Protein, GST-tagged In Vitro Cell Free System GST 493 amino acids
Human CYP2E1-220H Active Recombinant Human CYP2E1 Protein E.coli N/A
Human CYP2E1-0005H Recombinant Human CYP2E1 Protein (L32-S493), Tag Free E.coli No tag L32-S493
Human CYP2E1-430H Recombinant Human CYP2E1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CYP2E1-4425HFL Recombinant Full Length Human CYP2E1 protein, Flag-tagged Mamanlian cells Flag
Mouse Cyp2e1-5703M Recombinant Mouse Cyp2e1 protein, His-tagged E.coli His Pro34~Met273 (Accession # Q05421)
Mouse CYP2E1-4191M Recombinant Mouse CYP2E1 Protein Mammalian Cell His
Mouse CYP2E1-1373M Recombinant Mouse CYP2E1 Protein (2-493 aa), His-tagged Yeast His 2-493 aa
Mouse CYP2E1-2146M Recombinant Mouse CYP2E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CYP2E1-2146M-B Recombinant Mouse CYP2E1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cyp2e1-2417M Recombinant Mouse Cyp2e1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CYP2E1-1738R Recombinant Rat CYP2E1 Protein Mammalian Cell His
Rat Cyp2e1-5704R Recombinant Rat Cyp2e1 protein, His-tagged E.coli His Arg126~Arg309 (Accession # P05182)
Rat Cyp2e1-891R Recombinant Rat Cyp2e1 Protein, His-tagged E.coli N-His Ala2-Val125
Rat CYP2E1-1397R-B Recombinant Rat CYP2E1 Protein Pre-coupled Magnetic Beads HEK293
Rat CYP2E1-1397R Recombinant Rat CYP2E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human and Yeast CYP2E1-219H Recombinant Human CYP2E1and Yeast CYP-reductase S.cerevisiae N/A
Rhesus Macaque CYP2E1-1154R Recombinant Rhesus monkey CYP2E1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP2E1-979R-B Recombinant Rhesus Macaque CYP2E1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP2E1-979R Recombinant Rhesus Macaque CYP2E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig CYP2E1-134P Active Recombinant Pig CYP2E1 Protein E. coli
Kit-0935 CYP2E1 Blue Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2E1 Related Articles

CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP2P6;PLA2G6;PTGDS;PLA2G2E;CBR2;PLA2G3;PLA2G12B;GPX3;PLA2G2A
Biological oxidationsSult2a2;CYP2K6;UGT1B4;CYP1A2;FDX1L;AS3MT;POMCB;CYP27B1;CYP2V1
CYP2E1 reactionsCYP2A6;CYP2D6;CYP2B6;CYP2C8;CYP2Y3;CYP2C9;CYP2C19;CYP2E1;CYP2A13
Chemical carcinogenesisUGT2A3;GSTA4;CYP2C19;CYP2C70;UGT1A4;ADH4;ADH1B;UGT1A6;GSTA1
Cytochrome P450 - arranged by substrate typeCYP11B1;POMCB;CYP4A11;CYP2J2;CYP3A7;CYP2B6;CYP2C18;CYP19A1;CYP2U1
Drug metabolism - cytochrome P450CYP2D6;GSTK1;CYP2A6;ADH1A;ADH7;CYP2B6;GSTO2;ADH2-1;CYP2C19
Fatty Acid Omega OxidationADH1A;ADH1C;CYP2E1;ADH7;ADH4;CYP4A11;ADH6;CYP2D6;ADH1B
Folate-Alcohol and Cancer PathwayCYP2E1;ALDH1L1

CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, enzyme binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.

Function Related Protein
arachidonic acid epoxygenase activityCYP2AD3;CYP2A6;CYP2AA4;CYP2P10;CYP2P9;CYP2AA12;CYP2AA3;CYP2AA8;CYP2AA9
enzyme bindingEGFR;JUND;GNB2L1;ATG3;GSTM1;KMT2E;PLSCR1;HAND1;YWHAB
heme bindingCYP7B1;CYP2P10;CYP2J6;NGB;CYP2AA4;EIF2AK1;CYP4V7;CYP2Y3;CYCS
iron ion bindingISCUB;CYP7B1;CYP7A1;CYP4V8;CYP2P7;ACO2;FTH1;LTF;CYGB
monooxygenase activityCYP2P7;CYP1A1;CYP2C37;CYP1D1;CYP2AA6;CYP2AA3;CYP2P8;TH2;CYP3A4
oxidoreductase activityDHRS13A.3;SOD3A;HSD17B12A;CBR2;CYP2C70;PDHA1A;CYP3A41B;DHRS3B;HTATIP2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenMICAL1;CYP11B1;MICAL2;CYP4F2;MTRR;POR;CYP11C1;NDOR1;CYP11B2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2E1;CYP2C54;CYP2X10.2;CYP2B6;CYP2A13;CYP3A25;CYP2P8;CYP2C39;CYP2C9
oxygen bindingHBA2;BA1;HBE;CBS;CYP2X9;CYP2A12;HBAD;HBB;CYP2AD3
steroid hydroxylase activityCYP2P7;CYP2K22;CYP2P8;CYP2AA4;CYP2U1;CYP2J5;CYP2A6;CYP2F1;FAM84B

CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.

MAFG; CLU; PTN; ECHS1; RPL13A; GATM; NMI; ABCA5; AGXT2; LAMC3

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Safari, S; Motavaf, M; et al. Hepatotoxicity of Halogenated Inhalational Anesthetics. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2014).
  • Q&As
  • Reviews

Q&As (7)

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Are there known genetic polymorphisms in CYP2E1 associated with altered drug metabolism or disease risk? 05/03/2022

Genetic polymorphisms in CYP2E1 can result in altered enzyme activity, influencing an individual's response to drugs and susceptibility to liver damage.

What is the main function of CYP2E1 in drug metabolism? 10/19/2021

CYP2E1 oxidizes and metabolizes various small molecules, including drugs and toxins.

How does CYP2E1 contribute to the metabolism of ethanol and other toxins? 02/27/2021

It plays a significant role in ethanol metabolism and helps detoxify industrial solvents and other xenobiotics.

What factors can induce the expression of CYP2E1? 08/08/2020

Ethanol, fasting, and certain drugs can induce the expression of CYP2E1.

How is CYP2E1 linked to the generation of reactive oxygen species (ROS)? 11/15/2019

CYP2E1 activity generates ROS, contributing to oxidative stress and potential cellular damage.

In which tissues is CYP2E1 predominantly expressed? 01/24/2019

CYP2E1 is highly expressed in the liver, which is the main site for drug metabolism.

What role does CYP2E1 play in drug-drug interactions? 08/05/2018

CYP2E1 can contribute to drug-drug interactions, affecting the efficacy and toxicity of co-administered drugs.

Customer Reviews (3)

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Reviews
07/04/2022

    Product is as described.

    04/12/2022

      Fast and efficient service.

      12/19/2020

        Great for biological experiments.

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