cyp2e1
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  • Official Full Name
  • cytochrome P450, family 2, subfamily E, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;
Cat.#:CYP2E1-1373MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse CYP2E1 Protein (2-493 aa), His-tagged
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Cat.#:CYP2E1-2265HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2E1 Protein, GST-tagged
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Cat.#:CYP2E1-2475HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1
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Cat.#:CYP2E1-32HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1 protein, His-tagged
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Cat.#:CYP2E1-450HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2E1
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Cat.#:CYP2E1-452HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2E1 protein, MYC/DDK-tagged
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Cat.#:CYP2E1-547HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human CYP2E1
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Cat.#:CYP2E1-5702HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2E1 protein, His & GST-tagged
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Cat.#:CYP2E1-4191MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CYP2E1 Protein
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Cat.#:Cyp2e1-5703MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cyp2e1 protein, His-tagged
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Cat.#:CYP2E1-1738RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP2E1 Protein
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Cat.#:Cyp2e1-5704RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cyp2e1 protein, His-tagged
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Cat.#:CYP2E1-1154RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2E1 Protein, His-tagged
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Cat.#:CYP2E1-219HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human and Yeast
Product nameRecombinant Human CYP2E1and Yeast CYP-reductase
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Cat.#:CYP2E1-7111HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2E1 293 Cell Lysate
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Cat.#:Kit-0935Tag:
Source (Host):Species:
Product nameCYP2E1 Blue Screening Kit
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Involved Pathway

CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
GPX6; PLA2G4B; CYP2C19; AWAT2; PLA2G2E; DPEP1; CYP4A10; GGT5; CYP2C38; ALOX12B
Biological oxidations
CYP19A1; SULT1ST5; CYP3A7; ADH8B; CYP4F11; AADAC; SLC35B3; NAT2; CYP2Y3; ACY3.2
CYP2E1 reactions
CYP2F1; CYP2A6; CYP2E1; CYP2A7; CYP2A13; CYP2C9; CYP2S1; CYP2Y3; CYP2B6; CYP2C19
Chemical carcinogenesis
ADH5; ALDH1A3; GSTA2; GSTM7; PTGS2; CYP2C70; CYP1A1; GSTM4; GSTP2; GSTP1
Cytochrome P450 - arranged by substrate type
CYP27B1; FDXR; CYP26A1; CYP2S1; CYP2AD2; CYP3A7; CYP3A7-CYP3AP1; CYP2K16; CYP2C18; CYP1B1
Drug metabolism - cytochrome P450
CYP2E1; ADH4; CYP2A6; ADH2-1; CYP2C8; CYP2B6; ADH6; ADH1A; ADH1C; CYP3A5
Fatty Acid Omega Oxidation
ADH6; CYP1A1; ADH1B; ADH4; CYP4A11; ADH7; ADH1C; ADH1A; CYP2A6; CYP2E1
Folate-Alcohol and Cancer Pathway
ALDH1L1; CYP2E1

Protein Function

CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, enzyme binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2AD3; CYP2C50; CYP2AA2; CYP2A7; CYP2J5; CYP2F2; CYP4F2; CYP2F1; CYP2AA8; CYP2AA9
Function enzyme binding
Related Protein HDAC6; HIST1H2AK; ERN1; RPS2; ZNF346; BCHE; RAD9A; SCNM1-PS; DVL1; LUC7L2
Function heme binding
Related Protein CYP2D9; CYP39A1; HBG1; HBAE3; CYP2J2; CYP19A1B; CYP1A1; CYP4A11; HBA1; SDHC
Function iron ion binding
Related Protein CYP2J2; HBA-X; SC5D; CYP4V7; CYP2S1; ALOX12E; SC5DL; NOS2; CYP2X9; CYP2AA2
Function monooxygenase activity
Related Protein MICAL2B; CYP2C37; CYP1C2; CYP2P9; CYP2B19; CYP4A10; CYP2C50; CYP3A43; CYP2AA1; CYP2C18
Function oxidoreductase activity
Related Protein CYP2AA7; FOXRED1; CYP2A12; RDH14B; CYP2C8; GDI1; RDH14A; HEPHL1; CYP2AA8; FAM84B
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Related Protein CYP11B1; MTRR; MICAL1; CYP2E1; COQ6; POR; MICAL2; CYP11B2; CYP4F11; NDOR1
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2C70; CYP2C55; CYP2C19; CYP2J2; CYP2K18; CYP2R1; CYP2J5; CYP1B1; CYP2P7; CYP2A6
Function oxygen binding
Related Protein CYP2X10.2; HBA-X; CYP2C55; CYP2Y3; CYP2K19; CYP2P9; CYP2R1; CYP2C9; CYP2C38; CYP2C50
Function steroid hydroxylase activity
Related Protein CYP2B19; CYP2A7; CYP2F2; CYP2AA7; CYP2P10; CYP2X8; CYP2X7; CYP27A1; CYP2AA8; CYP2A13

Interacting Protein

CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.
MAFG; CLU; PTN; ECHS1; RPL13A; GATM; NMI; ABCA5; AGXT2; LAMC3

CYP2E1 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Safari, S; Motavaf, M; et al. Hepatotoxicity of Halogenated Inhalational Anesthetics. IRANIAN RED CRESCENT MEDICAL JOURNAL 16:-(2014).