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Official Full Name cytochrome P450, family 3, subfamily A, polypeptide 4
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680; cytochrome P450 3A4; OTTHUMP00000210308; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
    • Species :
    • Cynomolgus
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • P.pastoris
    • S.cerevisiae
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus CYP3A4-128C Recombinant Cynomolgus CYP3A4 Protein E. coli
    Human CYP3A4-347H Recombinant Human CYP3A4 Protein E.coli
    Human CYP3A4-5369H Recombinant Human CYP3A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP3A4-545H Recombinant Human CYP3A4 Protein (Ala2-Ala503), His-tagged E.coli His
    Human CYP3A4-81H Recombinant Human CYP3A4 Protein E. coli
    Human CYP3A4-11784H Recombinant Human CYP3A4, His-tagged E.coli His
    Human CYP3A4-18H Recombinant Human CYP3A4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP3A4-2273H Recombinant Human CYP3A4 Protein, GST-tagged Wheat Germ GST
    Human CYP3A4-26688TH Recombinant Human CYP3A4 Wheat Germ N/A
    Human CYP3A4-33H Recombinant Human CYP3A4/NADPH reductase protein P.pastoris N/A
    Human CYP3A4-436HCL Recombinant Human CYP3A4 cell lysate N/A
    Human CYP3A4-540H Recombinant Human CYP3A4 Insect Cell N/A
    Human CYP3A4-548H Recombinant Human CYP3A4 E.coli N/A
    Human CYP3A4-549H Recombinant Human CYP3A4 S.cerevisiae N/A
    Rhesus Macaque CYP3A4-1158R Recombinant Rhesus monkey CYP3A4 Protein, His-tagged Mammalian Cell His
    Kit-0907 CYP3A4 Green Screening Kit N/A
    Kit-0920 CYP3A4 Blue Screening Kit N/A
    Kit-1918 Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit N/A
    Kit-2142 Cytochrome P450 3A4 Inhibitor Screening Kit N/A

    CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aflatoxin B1 metabolism PRKRA; CYP2A13; FAM84B; CYP3A4; CYP1A2
    Aflatoxin activation and detoxification CYP2Y3; FAM84B; PRKRA; CYP3C1; CYP2A13; GGTLC1; DPEP1; CYP3C4; ACY3; CYP1A2
    Benzo(a)pyrene metabolism CYP3A4; CYP1A1; FAM84B; AKR1C2; AKR1C4; AKR1A1; CYP1B1
    Bile secretion NR1H4; Abcb1b; ATP1A1; ABCB11; FAM84B; SLC9A3; SLC51B; SLCO1A6; SULT2A1; Slc4a2
    Biological oxidations CYP3A7-CYP3AP1; CYP3C1; ADH4; CYP2A6; CYP2S1; SULT1ST5; CYP1A1; CES1; CYP4A11; CYP19A1
    Chemical carcinogenesis MGST3; UGT1A6; CYP3A4; EPHX1; SULT2A1; UGT2A1; SULT1A1; CYP3A25; GSTM6; CYP2C19
    Codeine and morphine metabolism SLCO1B1; CYP2D6; CYP3A4; ABCC2; FAM84B
    Cytochrome P450 - arranged by substrate type FDX1L; CYP4A11; CYP24A1; CYP11B2; CYP3C4; CYP2B6; CYP4F11; CYP1B1; CYP2K6; CYP4B1

    CYP3A4 has several biochemical functions, for example, albendazole monooxygenase activity, aromatase activity, caffeine oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.

    Function Related Protein
    albendazole monooxygenase activity FAM84B; CYP3A4
    aromatase activity CYP2C70; CYP2J2; CYP2S1; CYP1A1; CYP19A1; CYP3A4; CYP2C9; CYP4A12A; CYP2J6; CYP1A
    caffeine oxidase activity CYP1A2; CYP3A4; CYP2C9; CYP2C38; CYP2C39; FAM84B
    enzyme binding CD4; UBE4B; PEX5; PUS7; CBX4; TARBP2; MTA1; HOXA9; ATXN10; HIST1H2AD
    heme binding NGB; CYP4A11; PTGESL; CYP4V8; CBS; CYP1C2; SDHC; HMOX1; CYP2Y3; CYP2F2
    iron ion binding CYP2N13; AOX3L1; CYP26C1; EGLN1B; CYP4F3; CYP2P6; P4HA1B; CYP2W1; CYP2AA4; CYP2J6
    monooxygenase activity CYP2X9; CYP4F14; CYP2AD2; CYP4V8; CYP2C39; CYP2C37; CYP39A1; CYP4A10; CYP1A4; CYP2K16
    oxidoreductase activity YWHAQA; OXNAD1; LOXL2B; CYP1A; GLUD1A; CYP7A1A; CYP3A41B; DHRS13B; CYP2P7; PCYOX1L
    oxygen binding CYP2P9; TH; HBA2; HBA1; CYP2Y3; CYP2S1; CYGB2; CYP2P7; HBAA; CYP2C18
    quinine 3-monooxygenase activity FAM84B; CYP3A4
    steroid binding PDIA2; ESR2A; PAQR7B; PAQR8; HSD3B5; PGRMC1; ESRRG; ESRRA; GPR30; HSD17B10
    steroid hydroxylase activity CYP2K22; CYP2X10.2; CYP2AA12; CYP2C39; CYP1A1; CYP2AD2; CYP2C54; CYP2A6; CYP2K18; CYP2D26
    taurochenodeoxycholate 6alpha-hydroxylase activity CYP3A4; FAM84B
    testosterone 6-beta-hydroxylase activity FAM84B; CYP3A25; CYP3A41B; CYP3A4; CYP3A41A
    vitamin D 24-hydroxylase activity CYP3A4; FAM84B; CYP1A1
    vitamin D3 25-hydroxylase activity CYP2R1; FAM84B; CYP3A4; CYP27A1

    CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.

    PGRMC1; GK

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).

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