cyp3a4
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  • Official Full Name
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680; cytochrome P450 3A4; OTTHUMP00000210308; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
Cat.#:CYP3A4-545HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP3A4 Protein (Ala2-Ala503), His-tagged
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Cat.#:CYP3A4-2273HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP3A4 Protein, GST-tagged
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Cat.#:CYP3A4-11784HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP3A4, His-tagged
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Cat.#:CYP3A4-18HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP3A4 protein, MYC/DDK-tagged
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Cat.#:CYP3A4-26688THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP3A4
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Cat.#:CYP3A4-33HTag:N/A
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human CYP3A4/NADPH reductase protein
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Cat.#:CYP3A4-540HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP3A4
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Cat.#:CYP3A4-548HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP3A4
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Cat.#:CYP3A4-549HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human CYP3A4
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Cat.#:CYP3A4-1158RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP3A4 Protein, His-tagged
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Cat.#:CYP3A4-436HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP3A4 cell lysate
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Cat.#:Kit-1918Tag:N/A
Source (Host):Species:
Product nameCytochrome P450 3A4 (CYP3A4) Activity Assay Kit
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Cat.#:Kit-2142Tag:N/A
Source (Host):Species:
Product nameCytochrome P450 3A4 Inhibitor Screening Kit
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Cat.#:Kit-0907Tag:N/A
Source (Host):Species:
Product nameCYP3A4 Green Screening Kit
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Cat.#:Kit-0920Tag:N/A
Source (Host):Species:
Product nameCYP3A4 Blue Screening Kit
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Involved Pathway

CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aflatoxin B1 metabolism
PRKRA; FAM84B; CYP1A2; CYP2A13; CYP3A4
Aflatoxin activation and detoxification
DPEP1; CYP3A4; FAM84B; GGTLC1; CYP3A5; ACY3.2; CYP2A13; CYP3C4; DPEP2; ACY3
Benzo(a)pyrene metabolism
AKR1A1; FAM84B; AKR1C2; CYP1B1; AKR1C4; CYP1A1; CYP3A4
Bile secretion
AQP4; NR0B2; ADCY7; SLC27A5; SLC22A8; KCNN2; ATP1B3; AQP1; SLC22A1; ABCB11
Biological oxidations
CYP27B1; GLYAT; DPEP2; NAT2; CYP2C8; CYP3A7; UGT1B3; CYP3C1; CYP3A4; GLYATL2
Chemical carcinogenesis
GSTM2; GSTM6; UGT1A6; UGT2A3; ADH4; GSTA2; ADH2-2; GSTA1; GSTO2; GSTA3
Codeine and morphine metabolism
SLCO1B1; FAM84B; CYP2D6; CYP3A4; ABCC2
Cytochrome P450 - arranged by substrate type
CYP4F22; CYP27B1; CYP2K19; CYP3A7; CYP2N13; CYP2K18; CYP3A7-CYP3AP1; CYP19A1; FAM84B; POMCB

Protein Function

CYP3A4 has several biochemical functions, for example, albendazole monooxygenase activity, aromatase activity, caffeine oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.
Function
Related Protein
Function albendazole monooxygenase activity
Related Protein FAM84B; CYP3A4
Function aromatase activity
Related Protein CYP2B19; CYP2F1; CYP2U1; CYP2D10; CYP3A25; CYP4Z1; CYP2S1; CYP2H1; CYP2J6; CYP1A1
Function caffeine oxidase activity
Related Protein FAM84B; CYP1A2; CYP2C38; CYP3A4; CYP2C39; CYP2C9
Function enzyme binding
Related Protein UGT1A7; PLAUR; TSPAN10; PUS7; PPP1R3B; UGT1A6A; PCCA; UBE4B; DDX5; HIST1H2AD
Function heme binding
Related Protein CYP2C8; CYP1A4; CYP17A2; CYP2K6; LPO; XGB; CYP4F3; HBG1; CYP2K19; CYP2N13
Function iron ion binding
Related Protein CYP19A1B; CYP2C8; P4HA1; CYP24A1; CYP2J2; CYP2D6; OGFOD2; CYP4A10; HBE; CYP2R1
Function monooxygenase activity
Related Protein CYP2C9; FMO2; CYP2K22; CYP2AA4; CYP2E1; FMO1; CYP11C1; CYP2AA7; PTGIS; CYP1A1
Function oxidoreductase activity
Related Protein CYP2P9; OSGIN2; IMPDH1A; RDH10A; CYP2AA9; DHDHL; GFOD1; RDH13; SCD; CYP2C8
Function oxygen binding
Related Protein HBAE3; CYP4B1; CYP2J6; CYP2AD6; CYP2A4; HBBE3; CYP2C18; TH; XGB; HBM
Function quinine 3-monooxygenase activity
Related Protein CYP3A4; FAM84B
Function steroid binding
Related Protein ESRRGA; ESRRGB; PAQR5A; GPR30; PAQR7; PAQR7B; NR3C2; ESR1; SULT1E1; PAQR8
Function steroid hydroxylase activity
Related Protein CYP2AA8; CYP46A1; CYP2P7; CYP2P6; CYP2AA4; CYP2D6; CYP2N13; CYP46A1.3; CYP2S1; CYP46A1.2
Function taurochenodeoxycholate 6alpha-hydroxylase activity
Related Protein FAM84B; CYP3A4
Function testosterone 6-beta-hydroxylase activity
Related Protein CYP3A41B; CYP3A4; CYP3A41A; CYP3A25; FAM84B
Function vitamin D 24-hydroxylase activity
Related Protein CYP1A1; CYP3A4; FAM84B
Function vitamin D3 25-hydroxylase activity
Related Protein CYP2R1; CYP3A4; FAM84B; CYP27A1

Interacting Protein

CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.
PGRMC1; GK

CYP3A4 Related Articles

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).