CYP3A4
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Official Full Name
cytochrome P450, family 3, subfamily A, polypeptide 4
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680; cytochrome P450 3A4; OTTHUMP00000210308; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus
- Homo sapiens (Human)
- Human
- Rhesus Macaque
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- In vitro E. coli expression system
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- P.pastoris
- S.cerevisiae
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP3A4 Related Articles
CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Aflatoxin B1 metabolism | CYP2A13;CYP3A4;FAM84B;CYP1A2;PRKRA |
Aflatoxin activation and detoxification | PRKRA;CYP3A4;CYP3C1;CYP2A13;ACY3.2;CYP1A2;FAM84B;ACY3.1;DPEP1 |
Benzo(a)pyrene metabolism | FAM84B;AKR1A1;AKR1C2;CYP3A4;CYP1A1;CYP1B1;AKR1C4 |
Bile secretion | SLC51A;OSTB;SLCO1A5;KCNN2;ADCY6;RXRA;ADCY8;EPHX1;SLC5A1 |
Biological oxidations | ADH7;AKR1A1;DPEP1;CYP2AD2;UGT1B4;CYP2E1;CYP1A1;PRKRA;UGT1B3 |
Chemical carcinogenesis | ADH2-1;PTGS2;ADH4;MGST2;GSTA4;FAM84B;GSTT1;GSTK1;ADH1A |
Cytochrome P450 - arranged by substrate type | CYP17A1;CYP2K19;CYP2B6;CYP1B1;CYP2F1;POMCB;CYP3C4;CYP51A1;CYP2A7 |
CYP3A4 has several biochemical functions, for example, aromatase activity, caffeine oxidase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.
Function | Related Protein |
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aromatase activity | CYP2C39;FAM84B;CYP3A4;CYP2C9;CYP2D6;CYP1A;CYP2D26;CYP1A2;CYP3A43 |
caffeine oxidase activity | CYP2C9;FAM84B;CYP2C39;CYP3A4;CYP2C38;CYP1A2 |
enzyme binding | STUB1;CPSF1;PRKCH;CDC20;KDM4C;ARRB2;KMT2E;HIST1H2AL;PLAUR |
heme binding | CYP4F11;CYBA;CYP46A1;CYP1D1;CYP2P10;CYP3C4;CYP2D9;CYP51A1;CYP21A1 |
iron ion binding | CYP4A11;CH25HL2;PLOD3;CYP26A1;TYW1;CYP2F1;CYP26B1;NOS2B;HBA-X |
monooxygenase activity | CYP7A1A;FMO2;CYP3A7;CYP2AD2;YWHAE2;YWHAE1;CYP3A4;CYP4F14;TYR |
oxidoreductase activity | ALDH9A1A.2;DIO3A;CYP2AA9;ALDH3A2A;GFOD1;Aldh1a7;HSD11B1LA;G6PDX;CYP17A2 |
oxygen binding | TH;CYP2AA3;CYP2Y3;CYP3A7;CYP3A5;CYP4B1;CYP2C8;HBD;CYP26A1 |
quinine 3-monooxygenase activity | FAM84B;CYP3A4 |
steroid binding | PAQR5B;AKR1D1;PAQR7;PAQR7B;CYP3A4;HSD11B2;ESR1;PAQR7A;HSD3B5 |
steroid hydroxylase activity | CYP2A6;CYP46A1;CYP2AD3;CYP2B19;CYP2U1;CYP2B6;CYP2AA3;CYP2K19;CYP46A1.2 |
taurochenodeoxycholate 6alpha-hydroxylase activity | CYP3A4;FAM84B |
testosterone 6-beta-hydroxylase activity | CYP3A41B;FAM84B;CYP3A41A;CYP3A4;CYP3A25 |
vitamin D 24-hydroxylase activity | CYP3A4;FAM84B;CYP1A1 |
vitamin D3 25-hydroxylase activity | CYP2R1;CYP3A4;FAM84B;CYP27A1 |
CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.
PGRMC1; GK
- Q&As
- Reviews
Q&As (7)
Ask a questionVariability in CYP3A4 activity due to genetic, environmental, and health factors results in diverse drug responses among individuals.
CYP3A4 inhibitors can increase, while inducers can decrease drug levels, affecting their safety and effectiveness.
CYP3A4 is predominantly expressed in the liver and intestines.
CYP3A4 is crucial for breaking down and clearing a wide variety of drugs and toxins from the body.
Genetic polymorphisms in CYP3A4 can result in altered enzyme activity, impacting drug metabolism.
Managing CYP3A4-mediated interactions may involve using drug interaction databases, adjusting drug dosages, or choosing alternative medications.
CYP3A4 activity is generally lower in infants, peaks in childhood, and varies in adults.
Customer Reviews (3)
Write a reviewSuperior quality, highly recommend.
Worked well, as described.
Perfect for protein studies.
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