CYP3A4

  • Official Full Name

    cytochrome P450, family 3, subfamily A, polypeptide 4

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    CYP3A4;cytochrome P450, family 3, subfamily A, polypeptide 4;HLP;CP33;CP34;CYP3A;NF-25;CYP3A3;P450C3;CYPIIIA3;CYPIIIA4;P450PCN1;MGC126680;cytochrome P450 3A4;OTTHUMP00000210308;cytochrome P450 3A3;cytochrome P450 HLp;cytochrome P450-PCN1;cytochrome P450 NF-25;quinine 3-monooxygenase;albendazole monooxygenase;P450-III, steroid inducible;glucocorticoid-inducible P450;taurochenodeoxycholate 6-alpha-hydroxylase;cytochrome P450, subfamily IIIA, polypeptide 3;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Cynomolgus
  • E.coli
  • S.Cerevisiae
  • HEK293
  • Mammalian Cells
  • Wheat Germ
  • P.pastoris
  • Insect Cells
  • In Vitro Cell Free System
  • His
  • Non
  • DDK
  • Myc
  • GST
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP3A4-11784H Recombinant Human CYP3A4, His-tagged E.coli Human His 154-503a.a.
CYP3A4-548H Active Recombinant Human CYP3A4 E.coli Human Non
CYP3A4-549H Active Recombinant Human CYP3A4 S.Cerevisiae Human Non
CYP3A4-18H Recombinant Human CYP3A4 protein, MYC/DDK-tagged HEK293 Human DDK&Myc
CYP3A4-1158R Recombinant Rhesus monkey CYP3A4 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP3A4-2273H Recombinant Human CYP3A4 Protein, GST-tagged Wheat Germ Human GST
CYP3A4-26688TH Recombinant Human CYP3A4 Wheat Germ Human Non 503 amino acids
CYP3A4-33H Recombinant Human CYP3A4/NADPH reductase protein P.pastoris Human Non
CYP3A4-363H Recombinant Human CYP3A4/NADPH protein, Active P.pastoris Human Non
CYP3A4-540H Recombinant Human CYP3A4 Insect Cells Human Non
CYP3A4-436HCL Recombinant Human CYP3A4 cell lysate Human Non
CYP3A4-117HF Recombinant Full Length Human CYP3A4 Protein In Vitro Cell Free System Human Full L. 503 amino acids
CYP3A4-128C Active Recombinant Cynomolgus CYP3A4 Protein E.coli Cynomolgus
CYP3A4-1301H Recombinant Human CYP3A4 Protein, His-tagged E.coli Human His Pro344-Asp497
CYP3A4-1905H Recombinant Human CYP3A4 Protein (Gly26-Ala503), N-His tagged E.coli Human His Gly26-Ala503
CYP3A4-2433HF Recombinant Full Length Human CYP3A4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 503 amino acids
CYP3A4-347H Active Recombinant Human CYP3A4 Protein E.coli Human
CYP3A4-5369H Recombinant Human CYP3A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CYP3A4-545H Recombinant Human CYP3A4 Full Length Transmembrane protein (Ala2-Ala503), His-tagged E.coli Human His Full L. 2-503aa
CYP3A4-7592HFL Recombinant Full Length Human CYP3A4 protein, Flag-tagged Mammalian Cells Human Flag Full L.
CYP3A4-81H Active Recombinant Human CYP3A4 Protein E.coli Human
CYP3A4-983R Recombinant Rhesus Macaque CYP3A4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP3A4-983R-B Recombinant Rhesus Macaque CYP3A4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Kit-0907 CYP3A4 Green Screening Kit Non
Kit-0920 CYP3A4 Blue Screening Kit Non
Kit-1918 Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit Non
Kit-2142 Cytochrome P450 3A4 Inhibitor Screening Kit Non
RFL25689HF Recombinant Full Length Human Cytochrome P450 3A4(Cyp3A4) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (2-503)

    Involved Pathway

    CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism,Aflatoxin activation and detoxification,Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations SULT1B1,GSTK1,CYP2J2,UGT1B4,CYP2K17,ACY3,UGT1B1,CYP2K19,CYP2S1,CYP4F11
    Cytochrome P450 - arranged by substrate type CYP4T8,CYP4F12,CYP46A1,CYP2C18,CYP7A1,CYP2K16,CYP11A1,CYP1B1,CYP19A1,CYP4F22
    Chemical carcinogenesis CYP2C39,UGT1A1,GSTK1,EPHX1,SULT1A4,CYP2E1,Nat3,GSTM2,CYP2C54,GSTA5
    Bile secretion ADCY7,SLCO1A4,ABCB1,SCARB1,SLC27A5,SLC9A1,ATP1A1,SLC51B,CYP7A1,CA2
    Benzo(a)pyrene metabolism AKR1C2,CYP1B1,CYP1A1,AKR1A1,FAM84B,AKR1C4
    Aflatoxin activation and detoxification ACY3,CYP3C1,FAM84B,CYP3A5,CYP3C4,CYP2A13,ACY3.1,DPEP2,GGTLC1,CYP2Y3
    Aflatoxin B1 metabolism FAM84B,PRKRA,CYP2A13,CYP1A2

    Protein Function

    CYP3A4 has several biochemical functions, for example, aromatase activity,caffeine oxidase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.

    Function Related Protein
    iron ion binding PPEF1,CYP2K6,CYP2P9,CYP3C4,JMJD6,CYP46A1.3,HBE1,C14orf169,PTGIS,ALOX5B.2
    caffeine oxidase activity CYP2C38,FAM84B,CYP2C9,CYP2C39,CYP1A2
    quinine 3-monooxygenase activity FAM84B
    heme binding CYP46A1.1,STC2,DGCR8,CYP7A1,HRG-1,CYP2A4,JAK2,CYP2S1,CYP2AD2,CYP4A10
    taurochenodeoxycholate 6alpha-hydroxylase activity FAM84B
    steroid binding PGR,SERPINA6,PAQR5,ESRRGA,HSD11B2,CYP21A2,PAQR7,ESR2A,SULT1E1,PAQR7B
    aromatase activity CYP2A7,CYP1D1,CYP3A7,CYP4B1,CYP1A4,CYP4A12A,CYP2D9,CYP19A1,CYP1A2,CYP3A25
    monooxygenase activity CYP2C50,FMO2,CYP2C8,CYP2K19,CYP39A1,CYP2C54,CYP2AA7,MICAL2B,CYP4A14,CYP26C1
    steroid hydroxylase activity CYP2C8,CYP2A6,CYP2P10,CYP2AA3,CYP2K6,CYP2J2,CYP2AA7,CYP2J6,CYP2AA12,CYP2C50

    Interacting Protein

    CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.

    PGRMC1;GK

    Resources

    References

    • Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).
    • Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

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