casp3
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  • Official Full Name
  • caspase 3, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
  • Synonyms
  • CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease
Cat.#:CASP3-0421HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP3 Protein, GST-Tagged
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Cat.#:CASP3-1642HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase
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Cat.#:Casp3-1641MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 3
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Cat.#:Casp3-1644RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Caspase 3
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Cat.#:CASP3-158HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3
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Cat.#:CASP3-192HTag:Met/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3, Met&His-tagged
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Cat.#:CASP3-293HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3 protein, His/MBP-tagged
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Cat.#:CASP3-334HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP3 protein, GST-tagged
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Cat.#:CASP3-342HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3, His tagged
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Cat.#:CASP3-621HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3 protein, His-tagged
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Cat.#:CASP3-622HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3 protein, His & T7-tagged
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Cat.#:Casp3-1643MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp3 protein
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Cat.#:Casp3-623MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp3 protein, His-tagged
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Cat.#:CASP3-1145RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CASP3 Protein
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Cat.#:Casp3-624RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp3 protein, His & T7-tagged
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Cat.#:Casp3-625RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp3 protein, His & T7-tagged
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Cat.#:CASP3-362CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CASP3 Protein, His-tagged
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Cat.#:CASP3-6290CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CASP3
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Cat.#:CASP3-36HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP3, His-tagged
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Cat.#:Casp3-748RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Caspase 3, His-tagged
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Cat.#:CASP3-7838HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP3 293 Cell Lysate
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Cat.#:CASP3-7839HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP3 293 Cell Lysate
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Cat.#:CBCRY39Tag:
Source (Host):E. coliSpecies:
Product nameCaspase-3
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Involved Pathway

Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CDC42L; FGF8; GNA12; RAC3B; MAPK6; RPS6KA5; NFKB1; TNFRSF1A; PAK2; CASP3B
p signaling pathway
SERPINE1; THBS1; IGF1; BBC3; CCNE1; BAX; ATM; Casp3; TSC2; EI24
Apoptosis
TICAM1; BCL2; PLEC; OCLN; IL1RAP; BOKA; PLECA; IKBKG; GZMF; PRKACG
Natural killer cell mediated cytotoxicity
FASLG; RAET1E; H60a; KIR2DS4; FCGR3A; TNFRSF10B; MAP2K2; GM-CSF; PIK3R1; ULBP2
TNF signaling pathway
MAP3K7; PIK3CD; ATF4; DNM1L; MAPK8; NFKB1; CXCL10; VCAM1; AKT1; TNFRSF1B
Serotonergic synapse
APP; CYP2C39; PLCB2; PLA2G4F; CYP2D9; GNG3; PLCB1; HTR2B; PRKCB; GNB1
Non-alcoholic fatty liver disease (NAFLD)
COX5A; NDUFB8; TRAF2; GSK3A; MAP3K11; NDUFB11; UQCR11; BAX; MLXIPL; PIK3R2
Alzheimers disease
CALM2; NDUFAB1; CYCS; BACE2; NOS1; IDE; NDUFA12; PPP3R2; COX6A2; SDHC
Parkinsons disease
NDUFV3; PRKACB; NDUFAB1; NDUFA12; HTRA2; ATP5B; SDHD; COX7B; COX7B2; NDUFS1
Amyotrophic lateral sclerosis (ALS)
PRPH; GRIN2D; NEFM; MAPK13; MAP2K3; CCS; CAT; PPP3R2; SOD1; CYCS
Huntingtons disease
GRIN1; PLCB2; UQCRC1; CREB3L3; DCTN4; Atp5g2; PLCB1; NDUFA9; ATP5D; HDAC2
Pertussis
TNF; ITGA5; PYCARD; C1S; Itgam&Itgb2; MAPK11; CFL2; ITGB2; FOS; C2
Legionellosis
APAF1; BCL2L13; RAB1A; RAB1B; IL18; IL1B; SEC22B; NAIP7; NFKB1; TLR5
Toxoplasmosis
PIK3CB; LAMB4; Toxoplasma Gondii Major Surface Antigen P30; HLA-DQA1; MAPK3; TNFRSF1A; LAMA1; HSPA8; AKT2; MAP2K3
Amoebiasis
SERPINB1; RAB7A; SERPINB4; CD1D; IL6; SERPINB1C; PLCB4; CXCL8; LAMA5; SERPINB3
Tuberculosis
FCER1G; CAMK2A; H2-AB1; CD209C; HLA-DRB4; IFNA12; NOS2; FADD; TGFB2; PIK3C3
Hepatitis B
TGFBR1; TGFB2; NFKB1; BAD; EGR3; CCND1; YWHAZ; MMP9; TIRAP; FOS
Herpes simplex infection
EIF2AK4; HLA-DOA; IFNGR1; TBPL2; MHC2DEB; PPP1CAB; TTC6; SRSF7B; TAF9B; C1QBP
Pathways in cancer
GRB2; PRKACB; PPARD; WNT7A; LPAR2; TFG; PTK2; ITGAV; MMP2; RARB
Viral carcinogenesis
SCRIB; ACTN2; GSN; HIST1H2BF; GTF2A2; HIST1H2BQ; HDAC9; HIST1H4F; HIST1H2BA; HDAC10
Proteoglycans in cancer
PIK3R2; MDM2; MAP2K1; WNT3A; ERBB3; ITGB1; PPP1CA; ARHGEF1; CAMK2G; ARHGEF12
MicroRNAs in cancer
HDAC1; PRKCE; GLS; PIM1; DICER1; PDGFB; MAPK7; TIMP3; MARCKS; HRAS
Colorectal cancer
RHOA; SMAD2; TGFB3; BAD; KRAS; TRP53; MSH3; MLH1; TP53; APC
Viral myocarditis
LAMA2; CD86; ACTB; SGCG; HLA-C; H2-Q10; Casp3; ITGAL; HLA-DQA2; RAC2

Protein Function

Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic-type endopeptidase activity
Related Protein CNTNAP5A; NOTS; PGA; DDI2; BACE1; SPPL2; ASPRV1; CTSD; NAPSA; ANK2B
Function cyclin-dependent protein serine/threonine kinase inhibitor activity
Related Protein CDKN1A; CDKN1BB; HEXIM1; CDKN2A; CDKN2D; CDKN1BA; CDKN2B; INCA1; CDKN2C; KAT2B
Function cysteine-type endopeptidase activity
Related Protein CASP2; CTSL.1; USP14; CTSF; USP19; CASP1; USP42; USP6; CTSL1B; CTLA2B
Function cysteine-type endopeptidase activity involved in apoptotic process
Related Protein CLC; CASP8; Casp3
Function cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein CASP6L1; Casp3; CASP3B; CASP6; CASP6L2; CASP3A; CASP7
Function cysteine-type peptidase activity
Related Protein CTSK; SENP7; DESI1; CASPC; CAPN2A; USP17L1P; UFSP2; CASP5; ALG13; USP12A
Function death receptor binding
Related Protein PIDD1; RIPK1; MYD88; FASLG; TMBIM1; CASP8; PRDM4; NOL3; Fasl; BID
Function hydrolase activity
Related Protein PPP4CB; PTPN2A; ATP2B1; OTUB1A; PA2G4B; DPEP3; DUB1; PARLA; CDC14A; ALP3
Function peptidase activity
Related Protein CTSJ; PRSS48; PRSS41; NPEPPS; CTSB; GM5136; TMPRSS13A; KLK12; CAPN3B; AGA
Function phospholipase A2 activator activity
Related Protein PLAA; Casp3
Function protease binding
Related Protein XBP1; ADAMTS4; HSPA6; ALPI; SERPINA1E; TYSND1; ELANE; SERPINA1A; THAP5; ITGAV
Function protein binding
Related Protein HIST1H1C; ID1; KHDC3; SEPT9; CD81; EIF3J; DNAJB9; COMT; CAMK2D; STIM1
Function protein complex binding
Related Protein GIT2; PPP2R2A; YWHAB; TAB1; ING2; WASF2; PPP1R9B; PAFAH1B1; WRN; THRA

Interacting Protein

Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.
THAP11; Parp1; Hdgf; Pkm; Rps18; Acta2; Fam21; Nucks1; Htt

Casp3 Related Articles

Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).