Casp3

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Casp3

Official Full Name caspase 3, apoptosis-related cysteine peptidase
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Synonyms CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Wheat Germ
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MBP
    • T7
    • Met
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP3-01H Recombinant Human CASP3 Protein, His-tagged E.coli His
    Human CASP3-1333H Recombinant Human CASP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CASP3-188H Recombinant Human CASP3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Casp3-771M Recombinant Mouse Casp3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ GST
    Human CASP3-158H Recombinant Human CASP3 E.coli N/A
    Human CASP3-1642H Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP3-192H Recombinant Human CASP3, Met&His-tagged E.coli Met/His
    Human CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E.coli His/MBP
    Human CASP3-334H Recombinant Human CASP3 protein, GST-tagged Human Wheat Germ GST
    Human CASP3-342H Recombinant Human CASP3, His tagged E.coli His
    Human CASP3-36H Recombinant Human CASP3, His-tagged E.coli His
    Human CASP3-621H Recombinant Human CASP3 protein, His-tagged E.coli His
    Human CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E.coli His/T7
    Human CASP3-7838HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Human CASP3-7839HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Mouse Casp3-1641M Recombinant Mouse Caspase 3 E.coli N/A
    Mouse Casp3-1643M Recombinant Mouse Casp3 protein E.coli N/A
    Mouse Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E.coli His
    Rat CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cell His
    Rat Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-748R Recombinant Rat Caspase 3, His-tagged E.coli His
    Cynomolgus Monkey CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cell His
    Chicken CASP3-6290C Recombinant Chicken CASP3 Mammalian Cell His
    CBCRY39 Caspase-3 E.coli N/A

    Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK11; MAP3K5; TGFB3; Fgf15; PTPN7; DUSP16; MAPK8IP2; NLK; GADD45G; RPS6KA1
    p signaling pathway SERPINB5; THBS1; CASP8; GTSE1; TNFRSF10B; GADD45AA; ZMAT3; RRM2B; CYCSB; GADD45AB
    Apoptosis BNIP3LB; CDK5RAP2; AIFM1; HMGB2; PRKACBA; Casp3; DERL3; LMNB1; IRF1B; AKT3A
    Natural killer cell mediated cytotoxicity PAK1; HLA-C; PIK3R2; PTPN6; PLCG2; HLA-G; IFNA1; ARAF; ULBP1; FYN
    TNF signaling pathway MLKL; MAP2K3; CREB3L3; PIK3R5; PIK3CG; PIK3CD; CREB3L2; PIK3CB; IKBKG; AKT1
    Serotonergic synapse GNB4; CYP2C39; GNAO1; CYP2J6; PLA2G4D; SLC18A2; ARAF; PTGS1; ALOX12E; ALOX8
    Non-alcoholic fatty liver disease (NAFLD) NDUFB1; NDUFA1; MLXIPL; MAPK9; NDUFV2; ADIPOR1; TNFRSF1A; ATF4; NDUFB9; SDHC
    Alzheimers disease LPL; NDUFA6; NDUFB5; NDUFB8; NOS1; NDUFA13; Atp5g2; TNF; GRIN2C; NDUFC2-KCTD14
    Parkinsons disease DRD1A; NDUFA11; ATP5O; CYCS; COX6B2; ATP5G1; NDUFB8; UQCR10; UQCRFS1; NDUFA1
    Amyotrophic lateral sclerosis (ALS) GPX1; PPP3R1; GRIA1; CASP9; BAX; MAPK11; ALS2; BCL2L1; GRIA2; MAP2K3
    Huntingtons disease POLR2K; NDUFS1; VDAC2; NDUFS6; COX8A; COX7B; DCTN4; UQCRFS1; CREB3L3; TFAM
    Pertussis Itgam&Itgb2; ITGB1; C1RA; TNF; Il23a; C1QB; ITGB2; RELA; CALM4; SERPING1
    Legionellosis IL12B; CLK1; EEF1A2; ITGB2L; MYD88; NFKB1; APAF1; TNF; HBS1L; RAB1
    Toxoplasmosis PIK3R5; SOCS1; BCL2; HLA-DRB3; LAMA1; CASP9; GNAO1; LAMA5; BIRC2; ALOX5
    Amoebiasis VCL; PIK3R5; COL27A1; TLR4; GNA14; PRKACG; SERPINB1B; TGFB1; PRKACB; ITGAM
    Tuberculosis ATP6V0C; CD209A; CAMP; CD209; LAMP1; IL1A; SPHK2; IL10RB; RFXAP; FCGR2A
    Hepatitis B STAT3; EGR3; PIK3R3; IFNAR1; IFNA21; DDX58; IFN-a; TGFBR1; MAPK9; IRF3
    Herpes simplex infection PER1; Ifna15; SRPK1B; EEF1DA; IL12BA; HLA-C; POU2F3; PILRA; IFNA2; TAF6L
    Pathways in cancer Pdgfa&Pdgfb; SFPI1; PIK3R3; AXIN1; BIRC5; FZD1; GNAS; SMAD2; NOS2; FGF8
    Viral carcinogenesis TRAF2; CDC20; HLA-F; YWHAZ; STAT5A; HDAC7; SRC; HDAC2; HIST1H2BL; IKBKG
    Proteoglycans in cancer GPC3; TLR2; PLCG1; TLR4; GPC1; WNT8A; THBS1; CAV1; RPS6KB2; FZD3
    MicroRNAs in cancer PDGFRA; CCND2; PRKCE; SPRY2; RAF1; RDX; FOXP1; CCNE1; ST14; HOXD10
    Colorectal cancer AXIN2; APC; CCND1; SMAD3; RAC3; MSH2; AKT1; PIK3R2; AKT2; TRP53
    Viral myocarditis HLA-C; HLA-DMA; MYH7; H2-AA; H2-AB1; CASP8; ICAM1; EIF4G2; RAC3; CD80

    Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity SPPL3; REN; DDI2; CTSE; NRIP2; Casp3; CNTNAP5A; REN2; ASPRV1; NAPSA
    cyclin-dependent protein serine/threonine kinase inhibitor activity HEXIM2; CDKN2D; CDKN2A; CDKN1D; CDKN2B; KAT2B; CDKN2C; CDKN1B; CDKN1A; CDKN1BB
    cysteine-type endopeptidase activity CTSSB.1; CASP1; USP12; CTSL1; USP20; LGMN; USP27X; CASP9; USP43A; USP19
    cysteine-type endopeptidase activity involved in apoptotic process CASP8; Casp3; CLC
    cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP3B; CASP6L2; CASP7; CASP3A; CASP6L1; Casp3; CASP6
    cysteine-type peptidase activity CTSB; CAPN3B; CASP8; CASP7; CAPN2A; CTSM; UFSP2; PSD; CAPN1A; ATG4B
    death receptor binding PIDD1; CASP8; Fasl; MYD88; BID; TMBIM1; PRDM4; RIPK1; FEM1B; NOL3
    hydrolase activity URAH; PPP4CA; MEIOB; DAGLB; OVCA2; BPGM; ATP13A3; PLCH2; CASP3A; PNPLA8
    peptidase activity GM5136; REN2; MPND; CAPN12; DUB1; Ren1; ASTL; HE2; TPP1; LGMN
    phospholipase A2 activator activity Casp3; PLAA
    protease binding DPP4; SERPINB13; HSPD1; ITGB3; CD28; ECM1; VWF; CFLAR; XBP1; POLG
    protein binding MFN2; FBP2; PSMG2; SETDB2; INPP5B; MAP2K6; C16orf87; SLC6A20B; EVL; CTNNB1
    protein complex binding FYB; PPARA; TUB; STRN; PPP1R9B; PGAM5; LRRC16A; DAG1; PFKP; ADM2

    Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.

    THAP11; Parp1; Hdgf; Pkm; Rps18; Acta2; Fam21; Nucks1; Htt

    Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).

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