dact1
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  • Official Full Name
  • dishevelled-binding antagonist of beta-catenin 1
  • Background
  • The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms
  • DACT1; dishevelled-binding antagonist of beta-catenin 1; DPR1; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1; dapper homolog 1; dapper antagonist of catenin 1; heptacellular carcinoma novel gene 3; dapper, antagonist of beta-catenin, homolog 1; hepatocellular carcinoma novel gene 3 protein;
Cat.#:DACT1-2322HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DACT1 Protein, GST-tagged
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Cat.#:DACT1-3483CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DACT1
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Cat.#:DACT1-12757ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DACT1
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Cat.#:DACT1-7084HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DACT1 293 Cell Lysate
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Involved Pathway

Dact1 involved in several pathways and played different roles in them. We selected most pathways Dact1 participated on our site, such as Degradation of DVL, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dact1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of DVL
DVL3; DVL1; DVL2; HECW1; HECW1B; DACT1; KLHL12
Signal Transduction
FABP11B; ROR1; NPS; FGFBP3; FAM13B; ARHGAP22; OPN1LW1; GNA13B; WWOX; CCRL2
Signaling by Wnt
DACT1; SOX4B; RSPO4; FAM123B; WLS; RSPO1; PRICKLE1; CBY1; LEO1; TNKS2
TCF dependent signaling in response to WNT
DACT1; SRY; CDC73; RBBP5; LGR5; BCL9; SOX6; TLE3B; WIF1; LGR4

Protein Function

Dact1 has several biochemical functions, for example, beta-catenin binding, delta-catenin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Dact1 itself. We selected most functions Dact1 had, and list some proteins which have the same functions with Dact1. You can find most of the proteins on our site.
Function
Related Protein
Function beta-catenin binding
Related Protein CDH1; APC; PARK2; DVL3; PXN; PROP1; PSEN1; AXIN1; TBL1XR1; TRPC4
Function delta-catenin binding
Related Protein PTPRJ; CDH24; DACT3; PLEKHA7; PLEKHA7A; DACT2; DACT1
Function protein binding
Related Protein KRTAP4-12; DPH3; CDC42EP5; TNFRSF1A; RBMX; NRAP; TTC19; EGR2; ID1; C11orf46
Function protein kinase A binding
Related Protein DACT3; RPS3; MYRIP; AKAP7; DACT1; AKAP13; Akap2; Akap3; AKAP17A; AKAP12
Function protein kinase C binding
Related Protein SDPRA; PKP2; GLRX3; TRPV4; FLNA; SDPRB; PRKCB; HDAC7; AKT2; ADAM9

Interacting Protein

Dact1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dact1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dact1.
DVL2; YWHAB; CTNNB1; GSK3B; AXIN1; Prkaca; YWHAQ; SFN

Dact1 Related Articles

Gan, TQ; Tang, RX; et al. Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:714-721(2015).
Schussel, JL; Kalinke, LP; et al. Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. CANCER BIOMARKERS 15:11-17(2015).