dapk1
Share
  • Official Full Name
  • death-associated protein kinase 1
  • Background
  • Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
  • Synonyms
  • DAPK1; death-associated protein kinase 1; DAPK; DAP kinase 1; DKFZp781I035
Cat.#:DAPK1-2335HTag:GST/His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant HumanPK1 DAPK1 Protein, GST-His-tagged
+Inquiry
Cat.#:DAPK1-2336HTag:His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 Protein, His-tagged
+Inquiry
Cat.#:DAPK1-2337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DAPK1 Protein, GST-tagged
+Inquiry
Cat.#:DAPK1-985HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DAPK1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:DAPK1-11825HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged
+Inquiry
Cat.#:DAPK1-27363THTag:
Source (Host):Species:Human
Product nameRecombinant Human DAPK1
+Inquiry
Cat.#:DAPK1-289HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged, Active
+Inquiry
Cat.#:DAPK1-971HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1, His & GST tagged
+Inquiry
Cat.#:DAPK1-4304MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DAPK1 Protein
+Inquiry
Cat.#:DAPK1-1176RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DAPK1 Protein, His-tagged
+Inquiry
Cat.#:DAPK1-3251CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DAPK1
+Inquiry
Cat.#:DAPK1-5801ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DAPK1
+Inquiry
Cat.#:DAPK1-1395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1 (Active), GST-tagged
+Inquiry
Cat.#:DAPK1-602HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 cell lysate
+Inquiry

Involved Pathway

DAPK1 involved in several pathways and played different roles in them. We selected most pathways DAPK1 participated on our site, such as Apoptosis, Bladder cancer, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
PIK3CD; IRF4A; PIK3CB; CAPN2; CFLAR; TNFSF10; BNIP3L; PANK1A; TNFRSF1A; BCAP31
Bladder cancer
RASSF1; CDKN2A; CDH1; MMP1A; TYMP; BRAF; CDK4; KRAS; THBS1; ARAF
Caspase activation via extrinsic apoptotic signalig pathway
DCC; RNF8; TICAM1; DAPK3; CASP8L1; DAPK1
IFN-gamma pathway
IRF9; DAPK1
Ligand-independent caspase activation via DCC
RNF8; DAPK3; DAPK1
Pathways in cancer
SFPI1; MAPK3; WNT2; FZD1; KITLG; BIRC5; FGF3; FASLG; PRKCG; FGFR1
Programmed Cell Death
GZMC; STK24A; DIABLOB; BMX; DNM1L; DSP; HMGB2A; GAS2; GZMF; DSG2

Protein Function

DAPK1 has several biochemical functions, for example, ATP binding, GTP binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK1 itself. We selected most functions DAPK1 had, and list some proteins which have the same functions with DAPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SGK2; SNRK; PAK3; DGKD; DDX39AA; TIE1; ATAD3A; PIK3CA; ATP8A1; DNAJA2
Function GTP binding
Related Protein GNAV1; RHOAA; ACSM1; RAB14L; TUBB; EEF1A2; RAB6B; RAP1A; GBP4; KRAS
Function calmodulin binding
Related Protein SPTAN1; TJP1; EEA1; EDF1; CAMK1; ITPKC; CAMK1D; IQCB1; PHKA1; RRAD
Function calmodulin-dependent protein kinase activity
Related Protein CAMKK2; CAMK2B; MKNK2A; CAMK2B1; CAMKK1; CAMK4; MAPKAPK5; SLC14A2; MKNK2; MYLK3
Function identical protein binding
Related Protein GRB7; CASP6; TNF; GRIN3A; FAS; FBP1; ADIPOR2; CEACAM16; ERN1; S100B
Function protein binding
Related Protein IKBKE; SEC23B; HOXA3; USP9X; BAI2; NRG4; OGN; ZRSR2; PLIN1; NACA
Function protein kinase activity
Related Protein CDK7; TAOK1; SGK196; ACVR2AA; VRK1; CCND1; STK24B; SCYL1; IKBKAP; AKT2L
Function protein serine/threonine kinase activity
Related Protein CDKL5; RPS6KB1B; TSSK1; NUAK1; TAF1L; PRKCHA; MAP4K3; ACVR1; PRPF4B; PHKG1A
Function syntaxin-1 binding
Related Protein STXBP3; SNAP25A; STXBP1; SYBU; SNAP25; STXBP2; VAMP3; SLC6A4; UNC13A; MYO5A

Interacting Protein

DAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK1.
N/A; KLHL20; MAPK3

DAPK1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).