dapk1
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  • Official Full Name
  • death-associated protein kinase 1
  • Background
  • Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
  • Synonyms
  • DAPK1; death-associated protein kinase 1; DAPK; DAP kinase 1; DKFZp781I035
Cat.#:DAPK1-2335HTag:GST/His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant HumanPK1 DAPK1 Protein, GST-His-tagged
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Cat.#:DAPK1-2336HTag:His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 Protein, His-tagged
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Cat.#:DAPK1-2337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DAPK1 Protein, GST-tagged
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Cat.#:DAPK1-985HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DAPK1 Protein, MYC/DDK-tagged
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Cat.#:DAPK1-11825HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged
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Cat.#:DAPK1-27363THTag:
Source (Host):Species:Human
Product nameRecombinant Human DAPK1
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Cat.#:DAPK1-289HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged, Active
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Cat.#:DAPK1-971HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1, His & GST tagged
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Cat.#:DAPK1-4304MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DAPK1 Protein
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Cat.#:DAPK1-1176RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DAPK1 Protein, His-tagged
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Cat.#:DAPK1-3251CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DAPK1
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Cat.#:DAPK1-5801ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DAPK1
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Cat.#:DAPK1-1395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1 (Active), GST-tagged
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Cat.#:DAPK1-602HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 cell lysate
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Involved Pathway

DAPK1 involved in several pathways and played different roles in them. We selected most pathways DAPK1 participated on our site, such as Apoptosis, Bladder cancer, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
DSG2; TNFRSF10C; CASP10; SATB1; LMNB1; IL1B; ADD1; RNF8; HELLS; BADB
Bladder cancer
EGF; HBEGF; KRAS; CXCL8; ERBB2; UPK3A; MMP2; TYMP; TP53; CCND1
Caspase activation via extrinsic apoptotic signalig pathway
TICAM1; DCC; DAPK1; DAPK3; RNF8; CASP8L1
IFN-gamma pathway
IRF9; DAPK1
Ligand-independent caspase activation via DCC
DAPK1; RNF8; DAPK3
Pathways in cancer
TRAF4; MET; FH; AKT1; STK36; WNT6; HSP90AB1; LAMB1; IL-8; AXIN2
Programmed Cell Death
STK24B; STK26; DIABLOA; BCAP31; STK24A; DSG2; DIABLO; DSG1; CASP6L2; DSP

Protein Function

DAPK1 has several biochemical functions, for example, ATP binding, GTP binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK1 itself. We selected most functions DAPK1 had, and list some proteins which have the same functions with DAPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF5B; ACLYA; SMC1AL; PRKD1; FYN; OLA1; NADK2; PRKACBB; PAK2A; THRAP3
Function GTP binding
Related Protein RHOA; DNM1A; RASL11A; RASEF; HRASB; LANCL2; RAB34; ARL5C; TUBA2; TUBB4A
Function calmodulin binding
Related Protein RIT1; STRN; CAMK1GA; PLCB3; MYO1D; MAPKAPK2B; PHKG1A; EEA1; SPTBN1; SPHK1
Function calmodulin-dependent protein kinase activity
Related Protein CAMK1GA; ITPKA; MAPKAPK2A; MAPKAPK2; DAPK1; PTK2B; DAPK2A; CAMK1D; MAPKAPK2B; MKNK2B
Function identical protein binding
Related Protein PUF60; TRAF2; IGF2R; FHOD1; KCNJ2; SCHIP1; DESI1; ROBO1; COL2A1; ALDOA
Function protein binding
Related Protein CIAO1; MT1F; OTULIN; SPATA2; CD47; SILV; DNM3; ENG; MAPK11; STMN1
Function protein kinase activity
Related Protein CDK12; CASKB; PRKAB1; PRKCHB; MAPK12A; ULK1A; PRKDC; BMPR1AB; ACVR1; CDK11B
Function protein serine/threonine kinase activity
Related Protein NEK12; DYRK1B; PAK4; ULK1; GRK1A; LATS1; RAF1A; TSSK4; RPS6KA1; UHMK1
Function syntaxin-1 binding
Related Protein GOLSYN; SNAP25B; SNAP25A; CPLX1; MYO5A; STXBP2; RNF40; SYBU; CCDC167; VAMP3

Interacting Protein

DAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK1.
N/A; KLHL20; MAPK3

DAPK1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).