dcx
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  • Official Full Name
  • doublecortin
  • Background
  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
  • Synonyms
  • DCX; doublecortin; DC; DBCN; LISX; SCLH; XLIS; neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X;
Cat.#:DCX-2423HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DCX Protein, GST-tagged
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Cat.#:Dcx-681MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dcx Protein, His-tagged
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Cat.#:DCX-26890THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCX, His-tagged
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Cat.#:DCX-543HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DCX Protein, GST-tagged
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Cat.#:DCX-4376MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DCX Protein
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Cat.#:DCX-5907CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DCX
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Cat.#:DCX-7031HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DCX 293 Cell Lysate
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Cat.#:DCX-7032HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DCX 293 Cell Lysate
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Involved Pathway

DCX involved in several pathways and played different roles in them. We selected most pathways DCX participated on our site, such as Axon guidance, Developmental Biology, L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
MYL12A; CFL1; LOC608458; TRPC5; EVL; RASGEF1A; FRS2B; Unc5b; ADAM10; SEMA4B
Developmental Biology
LGI3; SCN2A; DPYSL5A; FGFR1B; SPRED1; KIF4A; RHOB; MED20; STX1B; COL9A3
L1CAM interactions
KIF4; CNTN6; SCN8A; SDCBP; EZRA; KCNQ3; SCN2A; CHL1; SCN3A; CNTN1
Lissencephaly gene (LIS1) in neuronal migration and development
DYNLT1; KATNA1; MAP1B; LRPAP1; NUDC; DAB1; DCX; VLDLR; NDEL1
Neurofascin interactions
DCX; CNTN1; SDCBP

Protein Function

DCX has several biochemical functions, for example, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCX itself. We selected most functions DCX had, and list some proteins which have the same functions with DCX. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-dependent protein serine/threonine kinase activity
Related Protein MAPKAPK2A; MAPKAPK2; MKNK2; MKNK2B; MAPKAPK2B; DCX; CAMK1GB; MAPKAPK5; MKNK2A; CAMK1GA
Function calmodulin binding
Related Protein PLCB3; PHKG1B; ENKUR; MYO1E; PDE1B; MYLK; KCNN1A; SPTAN1; MYO1G; MKNK2A
Function calmodulin-dependent protein kinase activity
Related Protein DAPK2A; CAMK1GA; CAMK2D1; ITPKA; MAPKAPK2; CAMK1D; MKNK2; MAPKAPK2A; MYLK3; DCX
Function microtubule binding
Related Protein PRNP; DYNC1I1; JAKMIP1; NDE1; MAPRE2; APC2; KIF25; EML1; VPS41; MAPRE1B
Function protein binding
Related Protein MEAF6; NEUROG1; BRD3; DNM1; CEACAM21; BMP10; RPS27A; RBMY1B; DGCR8; PRDM10
Function protein kinase binding
Related Protein RELA; PDGFRB; GCET2; KAT2B; ACVRL1; AP2A2; TRAF3; CNTLN; GOLGA2; GRB7

Interacting Protein

DCX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCX here. Most of them are supplied by our site. Hope this information will be useful for your research of DCX.
GOLGA2; IKZF1; ZBTB5; TRIM27; TRIM23; MEOX1

DCX Related Articles

Stanton, GB; Kohler, SJ; et al. Cytogenesis in the Adult Monkey Motor Cortex: Perivascular NG2 Cells Are the Major Adult Born Cell Type. JOURNAL OF COMPARATIVE NEUROLOGY 523:849-868(2015).
Lovelace, MD; Gu, BJ; et al. P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts. STEM CELLS 33:526-541(2015).