DCX
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Official Full Name
doublecortin
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Overview
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] -
Synonyms
DCX; doublecortin; DC; DBCN; LISX; SCLH; XLIS; neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Myc
- DDK
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DCX Related Articles
DCX involved in several pathways and played different roles in them. We selected most pathways DCX participated on our site, such as Axon guidance, Developmental Biology, L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | TRPC4;COL4A4;CREB1B;EPHA8;PPP3CA;DPYSL5A;EPHB4A;SEMA5B;FGFR1B |
| Developmental Biology | DUSP7;NR6A1;DRAP1;EFNA1;RHOGA;ARHGEF28;SPTA1;GPC1A;SDCBP |
| L1CAM interactions | CNTN6;SDCBP;NRP2;SCN2B;DCX;EZRA;DPYSL2;KCNQ3;SCN9A |
| Lissencephaly gene (LIS1) in neuronal migration and development | MAP1B;DAB1;NUDC;KATNA1;DCX;VLDLR;LRPAP1;DYNLT1;NDEL1 |
| Neurofascin interactions | DCX;CNTN1;SDCBP |
DCX has several biochemical functions, for example, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCX itself. We selected most functions DCX had, and list some proteins which have the same functions with DCX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein serine/threonine kinase activity | MKNK2A;MAPKAPK2B;MAPKAPK5;CAMK1GB;MKNK1;MAPKAPK2A;MKNK2;CAMK1GA;CAMK4 |
| calmodulin binding | KCNN2;ATPIF1;IQCB1;ENKUR;SLC8A2;MYH1;ADD1;MYLK;SRY |
| calmodulin-dependent protein kinase activity | MKNK2B;SLC14A2;MAPKAPK2A;CAMK4;CAMK1G;CAMK1D;CAMK1;CAMK2D2;CAMK2A |
| microtubule binding | MACF1;DPYSL5A;PAFAH1B1B;CAMSAP1A;NEFM;MAP2;CAMSAP1B;LC3;KIF13B |
| protein binding | CSE1L;SLAMF6;ATF5;HTN1;PIP5K1C;PEF1;TSPAN6;PRTFDC1;DAZAP2 |
| protein kinase binding | FAF1;B4GALT1;CACNB3;PTPRR;ELP2;PAK2;MAVS;MAPK4;Cd24a |
DCX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCX here. Most of them are supplied by our site. Hope this information will be useful for your research of DCX.
GOLGA2; IKZF1; ZBTB5; TRIM27; TRIM23; MEOX1
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