ddb2
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  • Official Full Name
  • damage-specific DNA binding protein 2, 48kDa
  • Background
  • This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DDB2; damage-specific DNA binding protein 2, 48kDa; DDBB; UV-DDB2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein;
Cat.#:DDB2-057HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDB2 Protein, GST-tagged
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Cat.#:DDB2-28309THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDB2 Protein, His-tagged
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Cat.#:DDB2-05THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDB2 Protein, GST-tagged
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Cat.#:DDB2-452HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDB2 Protein, His-tagged
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Cat.#:Ddb2-453HTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ddb2 Protein, His-tagged
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Cat.#:DDB2-1204RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDB2 Protein, His-tagged
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Cat.#:DDB2-3361CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDB2
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Cat.#:DDB2-5371ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDB2
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Cat.#:DDB2-7029HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDB2 293 Cell Lysate
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Involved Pathway

DDB2 involved in several pathways and played different roles in them. We selected most pathways DDB2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
NFRKB; INO80E; COPS6; INO80; ACTR5; PARP1; PARP2; YY1; GPS1; COPS3
DNA Repair
ZBTB32; MGMT; POLD3; EYA3; PIAS3; RAD51AP1; EME2; PPIE; USP43A; YY1
DNA damage response
RAD1; RAD9A; CDK5; RAD17; DDB2; HUS1B; GADD45A; CHEK2; TLK2; GADD45G
Direct p53 effectors
GADD45A; PLK3; TRIAP1; FOXA1; SMARCA4; NDRG1; DGCR8; CCNK; PCBP4; FDXR
Dual Incision in GG-NER
PARP2; DDB1; CHD1L; DDB2
Formation of Incision Complex in GG-NER
CETN2; PARP2; RNF111; DDB2; CHD1L; PIAS3; USP45; DDB1
Global Genome Nucleotide Excision Repair (GG-NER)
TFPT; YY1A; PIAS3; COPS2; COPS4; ACTR5; PARP2; INO80E; MCRS1; CHD1L
Hepatitis B
PIK3R2; IFN-a; TGFB2; VDAC3; NFKBIA; SMAD4; IFNA21; TLR3; SMAD3; IFNA1

Protein Function

DDB2 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB2 itself. We selected most functions DDB2 had, and list some proteins which have the same functions with DDB2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein PIAS4; ZNF10; PMS2; ZFP326; HOXB2A; ZFP687; CTC1; HOXA4; CALR; EPAS1
Function contributes_to damaged DNA binding
Related Protein DDB2; CUL4B; DDB1; NBN
Function protein binding
Related Protein TRAF5; FAM176B; CXCR5; TLR2; TTC17; SUV420H2; ZC3HAV1; NPC2; CDKN2B; CA4
Function contributes_to ubiquitin-protein transferase activity
Related Protein KLHL40A; KLHL23; KLHL12; KEAP1B; KCTD10; KLHL9; KLHL3; RNF40; TCEB3; TNFAIP1

Interacting Protein

DDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB2.
DDB1; COPS5; CUL4A; Ddb1; DDA1; E2F1; CUL4B; COPS6; GPS1