ddx1
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  • Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box helicase 1
  • Background
  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DDX1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DBP-RB; UKVH5d; ATP-dependent RNA helicase DDX1; DEAD box-1; DEAD box protein 1; DEAD box polypeptide 1; DEAD box protein retinoblastoma; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1;
Cat.#:DDX1-2461HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX1 Protein, GST-tagged
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Cat.#:DDX1-11888HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDX1, His-tagged
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Cat.#:DDX1-26545THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DDX1
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Cat.#:DDX1-4397MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDX1 Protein
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Cat.#:DDX1-1816RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DDX1 Protein
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Cat.#:DDX1-454CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DDX1 Protein, His-tagged
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Cat.#:DDX1-1212RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDX1 Protein, His-tagged
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Cat.#:DDX1-6132CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX1
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Cat.#:DDX1-7828ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDX1
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Cat.#:DDX1-7021HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDX1 293 Cell Lysate
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Involved Pathway

DDX1 involved in several pathways and played different roles in them. We selected most pathways DDX1 participated on our site, such as Aldosterone synthesis and secretion, Neuronal System, Potassium Channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aldosterone synthesis and secretion
ADCY3; NR4A1; KCNK9; PRKACA; CREB3L2; ATF2; CREB3L1; CALM3; ADCY9; PRKD3
Neuronal System
CHRNA1; LIN7B; LIN7C; GLS2B; KCNJ1B; KCNJ1A.2; PANX1B; KCNK13B; KCNK4; KCNN4
Potassium Channels
KCNQ2A; KCNK13B; KCNH1B; KCNJ1; DDX1; KCNN4; KCNG1; KCNA6; KCNS3; KCNC1
TWIK-releated acid-sensitive K+ channel (TASK)
KCNK3A; DDX1
Tandem pore domain potassium channels
KCNK2; KCNK4; KCNK7; KCNK1; KCNK2B; KCNK1B; DDX1; KCNK10B; KCNK13B; KCNK16

Protein Function

DDX1 has several biochemical functions, for example, S100 protein binding, ion channel activity, open rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX1 itself. We selected most functions DDX1 had, and list some proteins which have the same functions with DDX1. You can find most of the proteins on our site.
Function
Related Protein
Function S100 protein binding
Related Protein EZR; S100B; S100A11; S100A1; KCNK3; ANXA2; DDX1; AGER; S100A6; FGF1A
Function ion channel activity
Related Protein KCNV2B; TRPM4A; KCNH2A; RYR1B; SCN4AA; FXYD5; KCNC3B; AKR1C1; CLCN4-2; TRPM1
Function open rectifier potassium channel activity
Related Protein DDX1; KCNK3; KCNK3A
Function potassium channel activity
Related Protein KCNK13A; KCNG1; KCNC1A; KCNC1B; KCNC2; TMEM38B; KCNA2B; AQP1; KCNH5; KCNV2B
Function potassium ion leak channel activity
Related Protein KCNK9; KCNK13B; KCNK3A; DDX1; KCNK1B; KCNK2; KCNK13A; KCNK1; KCNK5A; KCNK18
Function protein C-terminus binding
Related Protein VGLL1; MSH2; FIGN; YEATS4; NCL; TOP2A; LIG4; VGLL2; SIAH1A; ERCC4
Function protein heterodimerization activity
Related Protein HIST1H4I; CRLF1; Defa-rs7; ADRB1; HIST1H4G; KCNK3; UGT1A2; SYT14; POLA2; HOMER2
Function protein homodimerization activity
Related Protein CRYM; CARD8; MAP3K13; IL17F; KIAA0947; SQSTM1; PVRL1B; BMP7A; TERT; PFKM

Interacting Protein

DDX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX1.
YWHAZ; RELB; SMAD2; NDRG1; NME7; 8-aha-camp; 8-aha-omethyladenosine; ssrna_ug