DDX11

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DDX11

Official Full Name DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase); probable ATP-dependent RNA helicase DDX11; CHL1; CHL1 like helicase
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX11-11890H Recombinant Human DDX11, GST-tagged E.coli GST
    Human DDX11-28322TH Recombinant Human DDX11, GST-tagged Wheat Germ GST
    Human DDX11-454HCL Recombinant Human DDX11 cell lysate N/A
    Mouse DDX11-4399M Recombinant Mouse DDX11 Protein Mammalian Cell His
    Zebrafish DDX11-1711Z Recombinant Zebrafish DDX11 Mammalian Cell His

    DDX11 involved in several pathways and played different roles in them. We selected most pathways DDX11 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IRE1alpha activates chaperones DDX11; PREB; CXXC1; DNAJB9; KLHDC3; FKBP14; TPP1; YIF1A; SEC61B; SERP1
    Metabolism of proteins SPON1A; ARSI; IGFBP6; SLC25A13; KDELR3; TRAPPC3; TIMM17B; EIF5A2; ADAMTS8; CBX8
    Unfolded Protein Response (UPR) CTDSP2; HYOU1; ASNA1; TPP1; KDELR3; FKBP14; YIF1A; PDIA6; YY2; HDGF
    XBP1(S) activates chaperone genes SERP1; FKBP14; TPP1; KDELR3; ASNA1; DNAJB9; CXXC1; HYOU1; KLHDC3; SEC63

    DDX11 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX11 itself. We selected most functions DDX11 had, and list some proteins which have the same functions with DDX11. You can find most of the proteins on our site.

    Function Related Protein
    4 iron, 4 sulfur cluster binding ISCUB; DPYDB; IREB2; POLD1; ISCU; REV3L; SDHB; NFU1; PRIM2; RSAD1
    ATP binding ACTR1A; ATP2A2; ACTC1; HCK; DGKG; NME4; PRKCHA; STK35; P2RX6; ACSBG1
    ATP-dependent DNA helicase activity RECQL; ERCC3; BLM; G3BP1; FBXO18; XRCC6; DDX3X; RUVBL2; BRIP1; GTF2H4
    DNA-dependent ATPase activity XRCC2; RAD51B; RAD51D; IGHMBP2; TTF2; XRCC3; CHD8; SMARCAL1; RAD51L3; MSH5
    RNA binding NHP2L1; RALY; FXR1; NUFIP1; RBM23; ADARB1; D19BWG1357E; EIF1AXB; WDHD1; OASL1
    double-stranded DNA binding RAD51; DMC1; MRE11A; EGFR; MCM10; FEN1; PRKDC; RAD51B; DDX58; PNKP
    helicase activity DDX19B; DHX58; ZRANB3; RAD54L; DHX36; PIF1; ANXA1; DDX52; MOV10; ATRX
    metal ion binding ZNF474; CYP2K16; NME4; ZBBX; ZDHHC21; OSGEPL1; NDUFS8; CISD1; NEK7; NKD2B
    protein binding AKAP13; RINT1; RGS1; GADD45GIP1; VDAC2; DHX38; RUNX1T1; IPO7; BRAF; SYCE2
    single-stranded DNA binding SETMAR; HNRNPK; TDP1; TDP2; LRPPRC; CRY2; FUBP1; CDC45; HNRNPA1; ERCC1

    DDX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX11.

    KAT7; PFN2

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