ddx11
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  • Official Full Name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
  • Background
  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase); probable ATP-dependent RNA helicase DDX11; CHL1; CHL1 like helicase
Cat.#:DDX11-11890HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDX11, GST-tagged
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Cat.#:DDX11-28322THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DDX11, GST-tagged
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Cat.#:DDX11-4399MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDX11 Protein
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Cat.#:DDX11-1711ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDX11
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Cat.#:DDX11-454HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDX11 cell lysate
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Involved Pathway

DDX11 involved in several pathways and played different roles in them. We selected most pathways DDX11 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX11 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IRE1alpha activates chaperones
HDGF; SERP1; CXXC1; DDX11; PREB; ADD1; TPP1; HYOU1; SEC63; WIPI1
Metabolism of proteins
CTDSP2; SMC5; FKBP9; TPP1; KDELR3; SEC61B; TIMM50; PFDN4; DDIT3; MGAT4A
Unfolded Protein Response (UPR)
CTDSP2; ASNA1; TPP1; CXXC1; SERP1; PDIA6; WIPI1; C19orf10; HDGF; DDX11
XBP1(S) activates chaperone genes
PDIA6; YIF1A; ASNA1; HDGF; FKBP14; KLHDC3; CTDSP2; TPP1; WIPI1; SEC63

Protein Function

DDX11 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX11 itself. We selected most functions DDX11 had, and list some proteins which have the same functions with DDX11. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein NUBP1; LIAS; NDUFS8B; ISCA2; NUBP2; ISCA1; MOCS1; ISCUB; PRIM2; ACO2
Function ATP binding
Related Protein ABCG2B; RUNX2; DARS; PSKH2; SNRKB; PRKCA; YME1L1B; SKIV2L; MUSK; CCT4
Function ATP-dependent DNA helicase activity
Related Protein DDX11; ERCC3; FBXO18; BLM; XRCC5; XRCC6; RTEL1; RUVBL2; DHX9; ERCC2
Function DNA-dependent ATPase activity
Related Protein DDX11; IGHMBP2; ERCC2; RAD51B; RAD51C; RAD51L1; SMARCAL1; CHD8; XRCC2; DMC1
Function RNA binding
Related Protein HNRNPR; DPPA5; ILF3B; OAS1B; KHDC1A; SNRPD1; IMPDH2; DDX53; SRSF3; Aff2
Function double-stranded DNA binding
Related Protein MRE11A; NEIL3; HMGB2; KLF6; NTHL1; ERCC5; XRCC2; MTERF2; TDG; MEN1
Function helicase activity
Related Protein SMARCAL1; CHD6; CHD7; FANCM; NAV2; TDRD12; UPF1; DDX19B; DHX37; DDX58
Function metal ion binding
Related Protein ZKSCAN3; CPEB1B; ZDHHC23B; CYGB2; SOBPA; EXO5; ACACB; STK32C; ZNF521; PPARAA
Function protein binding
Related Protein LDOC1; RAB13; DPM1; ZBTB44; FCGR2A; RNF135; MYL6B; PLEKHO1; RBL1; SRPK3
Function single-stranded DNA binding
Related Protein RBMS1; NABP1A; MEIOB; RPA4; RPA3; NABP1; RAD51L1; HNRNPDL; RAD23A; CNBP

Interacting Protein

DDX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX11.
KAT7; PFN2