DDX5 Protein, DEAD (Asp-Glu-Ala-Asp) box helicase 5


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Official Full Name DEAD (Asp-Glu-Ala-Asp) box helicase 5
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
Synonyms DDX5; DEAD (Asp-Glu-Ala-Asp) box helicase 5; p68; HLR1; G17P1; HUMP68; probable ATP-dependent RNA helicase DDX5; DEAD box-5; RNA helicase p68; DEAD box protein 5; ATP-dependent RNA helicase DDX5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD);
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX5-2497H Recombinant Human DDX5 Protein, GST-tagged Wheat Germ GST
    Human DDX5-464H Recombinant Human DDX5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDX5-7004HCL Recombinant Human DDX5 293 Cell Lysate HEK293 N/A
    Cynomolgus Monkey DDX5-458C Recombinant Cynomolgus DDX5 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque DDX5-1221R Recombinant Rhesus monkey DDX5 Protein, His-tagged Mammalian Cell His
    Chicken DDX5-6390C Recombinant Chicken DDX5 Mammalian Cell His
    Zebrafish DDX5-11891Z Recombinant Zebrafish DDX5 Mammalian Cell His

    DDX5 involved in several pathways and played different roles in them. We selected most pathways DDX5 participated on our site, such as Direct p53 effectors, Proteoglycans in cancer, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Direct p53 effectors ARID3A; EDN2; NDRG1; BNIP3L; CCNK; PCBP4; RNF144B; SCN3B; EPHA2; TADA2B
    Proteoglycans in cancer WNT5A; WNT7B; GRB2; HOXD10; HSPG2; TLR2; Casp3; EZR; MDM2; SOS1
    Spliceosome HNRNPC; RBM8A; SRSF7A; PPIL1; SRSF1B; SRSF6A; PRPF8; DHX16; SF3B6; DDX46
    Transcriptional misregulation in cancer WT1; PRCC; FUS; SP1; ZBTB16; KDM6A; MET; PLAT; HIST1H3D; H3F3C

    DDX5 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX5 itself. We selected most functions DDX5 had, and list some proteins which have the same functions with DDX5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding YME1L1; UBE2QL1; CDK6; CDK12; MYO7AA; MYH1E; PRKCH; SGK1; ABCA13; KCNJ11
    ATP-dependent RNA helicase activity DDX39B; EIF4A1B; DDX19A; DHX9; DDX54; DDX19; DDX39A; SKIV2L; DDX42; CHST13
    RNA helicase activity PRIM2; DDX5; DDX10; DDX6; RAD54B; DHX16; DHX9; SKIV2L2; UAP1L1; CTU1
    androgen receptor binding CTNNB1; FHL2; SMARCA4; PIAS1; PARK7; KDM3A; KDM1A; RAN; RB1; PRKCB
    calcium-dependent protein binding ANXA3; S100B; VLDLR; CHP; ANXA1; TNNI3; VAMP2; STX2; CALM2; DDX5
    calmodulin binding CAMK2B; NOS3; NOS1; PLCB3; PPP3R1; KCNQ1; GEM; RGS4; MYH1B; MYH4
    enzyme binding CNTNAP2; SCNM1-PS; KDM4C; CYP2C8; PAWR; PTEN; CYP2A4; HDAC3; TSPAN5; HAND1
    estrogen receptor binding DYX1C1; PADI2; TRIP4; PCNA; CCDC62; XBP1; FOXL2; HSD17B10; PPID; FUS
    poly(A) RNA binding R3HDM2; SAFB; RBM19; MRPS15; SRSF12; ELAC2; REPIN1; SUB1; ZFP346; MRPL4
    pre-mRNA binding SRSF2; TARBP2; RBM22; PTBP1; DDX5
    protein binding PLD2; CENPA; SH3YL1; MAPRE2; MLPH; PPP1R16B; PIH1D2; SFRS9; GPANK1; DUSP7
    transcription coactivator activity SAP130; GTF2F1; GRIP1; PRMT2; GTF2A1L; PER2; SP4; TDRD3; TAF10; ZSCAN1

    DDX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX5.

    ESR1; p27958-pro_0000037577

    Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
    Geissler, V; Altmeyer, S; et al. The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. NUCLEIC ACIDS RESEARCH 41:7875-7888(2013).

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