ddx5
Share
  • Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box helicase 5
  • Background
  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DDX5; DEAD (Asp-Glu-Ala-Asp) box helicase 5; p68; HLR1; G17P1; HUMP68; probable ATP-dependent RNA helicase DDX5; DEAD box-5; RNA helicase p68; DEAD box protein 5; ATP-dependent RNA helicase DDX5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD);
Cat.#:DDX5-2497HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX5 Protein, GST-tagged
+Inquiry
Cat.#:DDX5-464HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDX5 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:DDX5-458CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DDX5 Protein, His-tagged
+Inquiry
Cat.#:DDX5-1221RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DDX5 Protein, His-tagged
+Inquiry
Cat.#:DDX5-6390CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX5
+Inquiry
Cat.#:DDX5-11891ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DDX5
+Inquiry
Cat.#:DDX5-7004HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDX5 293 Cell Lysate
+Inquiry

Involved Pathway

DDX5 involved in several pathways and played different roles in them. We selected most pathways DDX5 participated on our site, such as Direct p53 effectors, Proteoglycans in cancer, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Direct p53 effectors
EPHA2; AIFM2; SCN3B; CSE1L; DDX5; DUSP1; ARID3A; DGCR8; FDXR; DDB2
Proteoglycans in cancer
WNT2; PDCD4; HIF1A; GPC1; RPS6KB2; CBLB; MAPK1; FZD5; TLR2; PPP1CB
Spliceosome
HNRPKL; CDC5L; RBMX; SNRPC; HNRNPA1A; TTC6; PUF60; WBP11; SF3A1; SRSF3
Transcriptional misregulation in cancer
IL2RB; CLSTN2; MEF2C; MMP3; GZMB; CD14; CD40; ITGB7; ARNT2; MEN1

Protein Function

DDX5 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX5 itself. We selected most functions DDX5 had, and list some proteins which have the same functions with DDX5. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ORC4L; KIFC1; DAPK1; MAT1A; PIP4K2B; PRKCHB; AK5L; KCNJ8; KIF9; UBA3
Function ATP-dependent RNA helicase activity
Related Protein DHX57; DHX8; DHX15; DDX3; DDX55; PL10; EIF4A1B; DDX4; EIF4A1; FAM120B
Function RNA helicase activity
Related Protein UAP1L1; DDX5; PRIM2; FAM120B; DHX16; RAD54B; DDX17; CHST13; CCDC111; DDX24
Function androgen receptor binding
Related Protein RB1; CALR; CDK7; PIAS1; CTNNB1; FHL2; FOXH1; CCNE1; RNF6; PKN1
Function calcium-dependent protein binding
Related Protein CALM1; CALM2; RBM22; MYO5A; C9orf9; NELF; ANXA1; MMP13; ANXA2; VPS37C
Function calmodulin binding
Related Protein MYO1F; CAMK2D2; RYR3; KCNQ1; KCNQ3; KCNN1A; OBSCN; SNTB1; PHKG2; NETO2
Function enzyme binding
Related Protein HMGA1-RS1; HDAC1; BCHE; EIF2AK3; CYP2C19; AKT1; IL6R; APBA3; MAT2B; NR5A1
Function estrogen receptor binding
Related Protein CCDC62; PPID; ARRB1; FUS; XBP1; TRIP4; DDX5; TAF10; DYX1C1; CNOT1
Function poly(A) RNA binding
Related Protein SMG1; HNRNPL; PHF5A; HIST1H4L; ENO1; RPS27.1; YBX1; BRIX1; EIF2C3; RBM15
Function pre-mRNA binding
Related Protein DDX5; RBM22; PTBP1; TARBP2; SRSF2
Function protein binding
Related Protein CCNF; SLC1A2; FLAD1; FAM101A; LANCL1; GFPT2; CDC16; HIST1H4E; RPS3; CLK3
Function transcription coactivator activity
Related Protein TAF7; RXRA; NFKBIB; NR1I3; GTF2A2; KAT6A; TUBB3; MYCBP; CITED2; EDF1

Interacting Protein

DDX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX5.
ESR1; p27958-pro_0000037577

DDX5 Related Articles

Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
Geissler, V; Altmeyer, S; et al. The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. NUCLEIC ACIDS RESEARCH 41:7875-7888(2013).