ddx6
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  • Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box helicase 6
  • Background
  • The lymphoma-associated Rck/p54 gene product is a member of the DEAD box protein/RNA helicase family which has a variety of functions including translation initiation, pre-mRNA splicing, and ribosome assembly. Overexpression of human Rck in a guinea pig c
  • Synonyms
  • DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6; oncogene RCK; DEAD box protein
Cat.#:DDX6-28328THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX6 protein, GST-tagged
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Cat.#:DDX6-45HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDX6 protein, MYC/DDK-tagged
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Cat.#:DDX6-4433MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDX6 Protein
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Cat.#:DDX6-1464CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX6
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Cat.#:DDX6-5430CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX6
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Cat.#:DDX6-6998HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDX6 293 Cell Lysate
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Involved Pathway

DDX6 involved in several pathways and played different roles in them. We selected most pathways DDX6 participated on our site, such as Deadenylation-dependent mRNA decay, Gene Expression, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deadenylation-dependent mRNA decay
C2orf29; LSM6; DDX6; EIF4A1; NT5C3B; EIF4EB; EIF4A2; PAIP1; TNKS1BP1; EIF4B
Gene Expression
ZNF189; TSNAX; EARS2; AIMP1; HNRNPF; ZNF486; SNAPC1A; DNAJC8; ZNF557; NR0B1
RNA degradation
HSPA9; XRN1; ENO1A; MPHOSPH6; CNOT3A; BTG2; CNOT3B; PABPC1L2A; DIS3; CNOT4
mRNA decay by 5 to 3 exoribonuclease
LSM6; DDX6; DCP1B

Protein Function

DDX6 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX6 itself. We selected most functions DDX6 had, and list some proteins which have the same functions with DDX6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ROR2; RIMKLA; ABCG4B; UBE2T; MYLK4; TDRD9; ACSBG1; SKIV2L; NAIP7; CDK5
Function ATP-dependent RNA helicase activity
Related Protein EIF4A2; DDX5; DHX36; TMEM38A; DDX43; DDX56; DHX9; DDX39AA; PL10; DHX33
Function RNA helicase activity
Related Protein DDX6; UAP1L1; DDX10; DHX9; PRIM2; FAM120B; DDX24; RAD54B; SKIV2L2; DDX5
Function helicase activity
Related Protein SMARCAL1; DHX33; GTF2F2B; MOV10B.2; CHD7; SHPRH; MCM9; PIF1; MOV10B.1; ANXA1
Function poly(A) RNA binding
Related Protein ROCK2; NAT10; DARS; TRMT1; KIAA0020; ATXN2; PSPC1; PRMT1; PTCD2; RALY
Function protein binding
Related Protein POT1A; MME; YWHAG; KLHL3; PECAM1; GTF2H2C_2; DEF6; TMX3; NEUROD1; DNAI1
Function protein domain specific binding
Related Protein THRA; DDC; PKD1; ACSL3; PPARA; CALM; E2F4; NEDD4; RAPGEF3; PLG

Interacting Protein

DDX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX6.
DCP1A; EDC3; YBX1; TRIM37

DDX6 Related Articles

Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
Kawahara, C; Yokota, S; et al. DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells. HISTOCHEMISTRY AND CELL BIOLOGY 141:111-121(2014).