ddx6
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  • Official Full Name
  • DEAD (Asp-Glu-Ala-Asp) box helicase 6
  • Background
  • The lymphoma-associated Rck/p54 gene product is a member of the DEAD box protein/RNA helicase family which has a variety of functions including translation initiation, pre-mRNA splicing, and ribosome assembly. Overexpression of human Rck in a guinea pig c
  • Synonyms
  • DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6; oncogene RCK; DEAD box protein
Cat.#:DDX6-28328THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDX6 protein, GST-tagged
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Cat.#:DDX6-45HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDX6 protein, MYC/DDK-tagged
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Cat.#:DDX6-4433MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DDX6 Protein
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Cat.#:DDX6-1464CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX6
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Cat.#:DDX6-5430CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DDX6
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Cat.#:DDX6-6998HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DDX6 293 Cell Lysate
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Involved Pathway

DDX6 involved in several pathways and played different roles in them. We selected most pathways DDX6 participated on our site, such as Deadenylation-dependent mRNA decay, Gene Expression, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Deadenylation-dependent mRNA decay
EIF4EB; EIF4A2; D1BWG0212E; EIF4A1; DCP2; EIF4B; EIF4G1; TNKS1BP1; DDX6; NT5C3B
Gene Expression
CHD4A; ZNF79; ZNF34; ZNF771; LAGE3; ZNF460; FAM98B; APOBEC1; ZNF560; RARAA
RNA degradation
PABPC4; ENO2; EDC4; EXOSC4; PATL1; CNOT3B; BTG3; PFKL; XRN2; EXOSC9
mRNA decay by 5 to 3 exoribonuclease
LSM6; DDX6; DCP1B

Protein Function

DDX6 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX6 itself. We selected most functions DDX6 had, and list some proteins which have the same functions with DDX6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMC5; KIF11; PTK2B; ATP8B1; PDS5B; TNK2B; RAF1B; EPHA4; ITK; PAK6
Function ATP-dependent RNA helicase activity
Related Protein DHX34; SUPV3L1; EIF4A1B; DDX56; DDX18; DDX50; DHX36; DDX6; CHST13; DHX15
Function RNA helicase activity
Related Protein DDX6; UAP1L1; CCDC111; DHX15; DHX16; PRIM2; DDX5; CHST13; DDX10; SKIV2L2
Function helicase activity
Related Protein TDRD9; CHD9; GTF2F2B; ATRX; SMARCA5; SMARCAD1; EIF4A2; DHX57; PEO1; ACTG2
Function poly(A) RNA binding
Related Protein HMGN2; PSMC1; EIF3D; C4BPA; CELF2; DDX27; ZC3H15; HDAC2; ERI3; MFAP1
Function protein binding
Related Protein TBC1D7; FAM134B; DULLARD; DYRK1A; GGA3; LSM4; GRM2; ZBTB7C; GM885; RNF7
Function protein domain specific binding
Related Protein THRA; HIST1H4H; ARFIP2B; LAMP1; SNCA; MYH9; CALM; TFDP2; CACNB2; RXRA

Interacting Protein

DDX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX6.
DCP1A; EDC3; YBX1; TRIM37

DDX6 Related Articles

Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
Kawahara, C; Yokota, S; et al. DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells. HISTOCHEMISTRY AND CELL BIOLOGY 141:111-121(2014).