Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members;of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early;endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024).;Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed;20154091)).
DENND1B; DENN/MADD domain containing 1B; C1orf218, chromosome 1 open reading frame 218 , FAM31B, family with sequence similarity 31, member B; DENN domain-containing protein 1B; FLJ20054; MGC27044; C1ORF18; C1orf218; Chromosome 1 open reading frame 218; DEN1B_HUMAN; DENN domain containing protein 1B; DENN MADD domain containing 1B; DKFZp547O0715; FAM31B; Family with sequence similarity 31 member B; FLJ21179; FLJ33888; MGC103810; Protein FAM31B; connecdenn 2; family with sequence similarity 31, member B; RP11-53I24.2
DENND1B has several biochemical functions, for example, Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DENND1B itself. We selected most functions DENND1B had, and list some proteins which have the same functions with DENND1B. You can find most of the proteins on our site.
Function Rab guanyl-nucleotide exchange factor activity
Related Protein DENND6AA; DENND1A; TRAPPC4; PRSS56; ALS2; DENND5A; DENND5B; RABGEF1; DENND1C; TRAPPC1
DENND1B Related Articles
Chawes, BLK; Bischoff, AL; et al. DENND1B Gene Variants Associate With Elevated Exhaled Nitric Oxide in Healthy High-Risk Neonates. PEDIATRIC PULMONOLOGY 50:109-117(2015).
Smith, NLD; Hankinson, J; et al. Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT. CLINICAL MICROBIOLOGY AND INFECTION 20:O960-O968(2014).