dnase2
Share
  • Official Full Name
  • deoxyribonuclease II, lysosomal
  • Background
  • This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
  • Synonyms
  • DNASE2; deoxyribonuclease II, lysosomal; DNL; DNL2; DNASE2A; Deoxyribonuclease-2-alpha; EC=3.1.22.1; Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2; deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha; NP_001366.1; EC 3.1.22.1; Acid DNase
Cat.#:DNASE2-2778HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DNASE2 Protein, GST-tagged
+Inquiry
Cat.#:DNASE2-449HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DNASE2 Protein, His-tagged
+Inquiry
Cat.#:DNASE2-470CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DNASE2 Protein, His-tagged
+Inquiry
Cat.#:DNASE2-6475ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DNASE2
+Inquiry
Cat.#:DNASE2-6863HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DNASE2 293 Cell Lysate
+Inquiry

Involved Pathway

DNASE2 involved in several pathways and played different roles in them. We selected most pathways DNASE2 participated on our site, such as Clathrin derived vesicle budding, Lysosome, Lysosome Vesicle Biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Clathrin derived vesicle budding
SNX9; SH3D19; TGOLN2; DNM2; TFR1B; HIP1R; FTH1A; NECAP1; CLTA; CLVS1
Lysosome
CTNS; NPC1; GALC; CTSBB; CD68; PLA2G15; NAGLU; AP1S3; AP4E1; ACP5
Lysosome Vesicle Biogenesis
CLVS2; CLVS1; DNASE2; AP1S3A; CTSZ; BLOC1S1; AP4B1
Membrane Trafficking
ANKRD28; COPE; NECAP1; TRAPPC2; GOLGA2; AP3S1; CX27.5; TERFA; TRAPPC6BL; TPD52
Vesicle-mediated transport
TRAPPC3; NAPB; GAK; GJA5; PICALMA; CTAGE5; GJB3; TRAPPC5; AMBP; FTH1A
trans-Golgi Network Vesicle Budding
CLINT1; AP4B1; TCEAL4; FTH1A; CNO; CLVS2; PLDN; AP3S1; TPD52L1; YIPF6

Protein Function

DNASE2 has several biochemical functions, for example, DNA binding, deoxyribonuclease II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE2 itself. We selected most functions DNASE2 had, and list some proteins which have the same functions with DNASE2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP692; TRIM16; DLX1A; HIST1H2AO; IRX4A; CCNT1; ZFY2; DOT1L; HOXB1; PROX1B
Function deoxyribonuclease II activity
Related Protein DNASE2A; DNASE2; DNASE2B

Interacting Protein

DNASE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE2.
RUVBL2; RUVBL1; cona_canen