dpagt1
Share
  • Official Full Name
  • dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
  • Background
  • The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme.
  • Synonyms
  • DPAGT1; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); DPAGT, DPAGT2; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; ALG7; CDG Ij; D11S366; DGPT; GPT; Gnpta; H2afx; AU021132; Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase); DPAGT2; G1PT; GlcNAc-1-P transferase; GPT_HUMAN; N-acetylglucosamine-1-phosphate transferase; OTTHUMP00000204052; OTTHUMP00000204055; dolichyl-phosphate alpha-N-acetylglucosaminyltransferase; UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra; UAGT; UGAT; CDG1J; DPAGT; CDG-Ij
Cat.#:DPAGT1-2822HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPAGT1 Protein, GST-tagged
+Inquiry
Cat.#:DPAGT1-4776MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPAGT1 Protein
+Inquiry
Cat.#:DPAGT1-1316RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DPAGT1 Protein, His-tagged
+Inquiry
Cat.#:DPAGT1-5545ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DPAGT1
+Inquiry
Cat.#:DPAGT1-6840HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DPAGT1 293 Cell Lysate
+Inquiry

Involved Pathway

DPAGT1 involved in several pathways and played different roles in them. We selected most pathways DPAGT1 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPAGT1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Asparagine N-linked glycosylation
TRAPPC9; CNIH2; ALG10B; YKT6; DERL2; GNE; ALG2; PREB; TRAPPC6B; ALG14
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
NANP; NEU4; DPAGT1; ST8SIA3; GNE; SLC35A1; ALG2; ST6GALNAC1.2; MPDU1B; NEU3
Metabolic pathways
CYP2R1; ENO1B; GLCEB; PLD4; NME6; ACSL1A; SYNJ1; CYP7A1; PGP; udp
Metabolism of proteins
IGFBP2B; ATPBD4; ADAMTSL1; TIMM9; MAN1B1; NAPG; TOMM6; SFTPB; ARSD; CPN1
N-Glycan biosynthesis
ST6GAL1; DPM1; FUT8; MGAT4A; MAN1B1; MGAT1B; ZNF408; DPAGT1; DPM3; DOLPP1
Post-translational protein modification
SCMH1; NEU4; ADAMTS8; ZNF408; ST6GALNAC2; MIA3; ADAMTSL5; SEC23IP; MUC21; ADAMTSL4
dolichyl-diphosphooligosaccharide biosynthesis
DPAGT1

Protein Function

DPAGT1 has several biochemical functions, for example, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, phospho-N-acetylmuramoyl-pentapeptide-transferase activity, transferase activity, transferring glycosyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by DPAGT1 itself. We selected most functions DPAGT1 had, and list some proteins which have the same functions with DPAGT1. You can find most of the proteins on our site.
Function
Related Protein
Function UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
Related Protein DPAGT1
Function phospho-N-acetylmuramoyl-pentapeptide-transferase activity
Related Protein DPAGT1
Function transferase activity, transferring glycosyl groups
Related Protein B3GAT1A; GLT1D1; UGT2A5; DPAGT1; UGT8A; GALNT18A; GLT8D1; UGT2B5; FUT9A; UGT5C1

Interacting Protein

DPAGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPAGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPAGT1.
MFSD3