dph2
Share
  • Official Full Name
  • DPH2 homolog (S. cerevisiae)
  • Background
  • This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • DPH2; DPH2 homolog (S. cerevisiae); diptheria toxin resistance protein required for diphthamide biosynthesis like 2 (S. cerevisiae) , DPH2 like 2 (S. cerevisiae) , DPH2L2; diphthamide biosynthesis protein 2; Diphthamide biosynthesis like protein 2; Diphthamide biosynthesis protein 2 homolog like 2; Diphthamide biosynthesis protein 2 homolog-like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae; DPH 2; DPH2 homolog; DPH2 homolog S. cerevisiae; DPH2 like 2; DPH2 like 2 S. cerevisiae; DPH2-like 2; DPH2_HUMAN; DPH2L2; HsDph2; OTTHUMP00000010007; Protein DPH2 homolog; OTTHUMP00000231247; diphthamide biosynthesis-like protein 2; diptheria toxin resistance protein required for diphthamide biosynthesis-like 2
Cat.#:DPH2-2831HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DPH2 Protein, GST-tagged
+Inquiry
Cat.#:DPH2-28432THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DPH2
+Inquiry
Cat.#:DPH2-4786MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DPH2 Protein
+Inquiry
Cat.#:DPH2-1939RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DPH2 Protein
+Inquiry
Cat.#:DPH2-1676CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DPH2
+Inquiry
Cat.#:DPH2-5537ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DPH2
+Inquiry
Cat.#:DPH2-6837HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DPH2 293 Cell Lysate
+Inquiry

Involved Pathway

DPH2 involved in several pathways and played different roles in them. We selected most pathways DPH2 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPH2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activation
GAS6; PROZ; ARSF; ATPBD4; FURINA; ARSE; DOHH; ARSH; F9B; DHPS
Metabolism of proteins
SCMH1; B3GALTL; DPH1; RAB27A; IGFBP6B; ARSE; SPON1A; SLC25A13; WIPI1; ADAMTSL5
Post-translational protein modification
SPON1A; ALG14; ARSF; GCNT3; MUC21; MUC4; SPON1; SLC35A1; B3GNT6; ADAMTSL5
Synthesis of diphthamide-EEF2
DPH1; OTOP2; DNAJC24; WDR85; DPH3; DPH2; ATPBD4; DPH5

Protein Function

DPH2 has several biochemical functions, for example, 2-(3-amino-3-carboxypropyl)histidine synthase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPH2 itself. We selected most functions DPH2 had, and list some proteins which have the same functions with DPH2. You can find most of the proteins on our site.
Function
Related Protein
Function 2-(3-amino-3-carboxypropyl)histidine synthase activity
Related Protein DPH2
Function protein binding
Related Protein FGFR1; FBXO5; NXF3; MRPL1; ORAI2; SPSB1; NDFIP1; C22orf29; ANLN; DAPK1

Interacting Protein

DPH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPH2.
IL17A

DPH2 Related Articles

Pemov, A; Sung, HJ; et al. Genetic Modifiers of Neurofibromatosis Type 1-Associated Cafe-au-Lait Macule Count Identified Using Multi-platform Analysis. PLOS GENETICS 10:-(2014).
Dong, M; Su, XY; et al. Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:1754-1757(2014).