DPH5

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DPH5

Official Full Name DPH5 homolog (S. cerevisiae)
Background This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; AD 018; AD018; CGI30; Diphthamide biosynthesis methyltransferase; NPD015; Protein x 0011; AD-018; CGI-30; HSPC143
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Dph5-2636M Recombinant Mouse Dph5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human DPH5-6497H Recombinant Human DPH5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DPH5-2477H Recombinant Human DPH5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DPH5-2835H Recombinant Human DPH5 Protein, GST-tagged Wheat Germ GST
    Human DPH5-507HCL Recombinant Human DPH5 cell lysate N/A
    Mouse DPH5-4788M Recombinant Mouse DPH5 Protein Mammalian Cell His
    Rhesus Macaque DPH5-1320R Recombinant Rhesus monkey DPH5 Protein, His-tagged Mammalian Cell His
    Zebrafish DPH5-1772Z Recombinant Zebrafish DPH5 Mammalian Cell His
    Zebrafish DPH5-5861Z Recombinant Zebrafish DPH5 Mammalian Cell His

    DPH5 involved in several pathways and played different roles in them. We selected most pathways DPH5 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gamma carboxylation, hypusine formation and arylsulfatase activation SUMF2; EIF5A; OTOP2; EEF2; WDR85; ARSJ; DPH2; ARSI; ARSE; DPH1
    Metabolism of proteins ARSE; PDIA6; GZMH; EEF1D; NAPB; PPP6C; MUC20; TOMM22; NAPG; TRAPPC6A
    Post-translational protein modification SENP1; TRAPPC3; NSMCE2; MUCL1; B3GNT8; ARSF; MUC21; TRAPPC2L; THSD7A; ALG2
    Synthesis of diphthamide-EEF2 OTOP2; DPH1; ATPBD4; DPH5; WDR85; DPH2; DPH3; DNAJC24
    diphthamide biosynthesis ATPBD4; DPH5

    DPH5 has several biochemical functions, for example, diphthine synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPH5 itself. We selected most functions DPH5 had, and list some proteins which have the same functions with DPH5. You can find most of the proteins on our site.

    Function Related Protein
    diphthine synthase activity DPH5

    DPH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPH5.

    Lin, ZW; Su, XY; et al. Dph7 Catalyzes a Previously Unknown Demethylation Step in Diphthamide Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136:6179-6182(2014).
    Abdel-Fattah, W; Scheidt, V; et al. Insights into Diphthamide, Key Diphtheria Toxin Effector. TOXINS 5:958-968(2013).

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