dsg3
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  • Official Full Name
  • desmoglein 3
  • Background
  • Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DSG3; desmoglein 3; PVA; CDHF6; desmoglein-3; cadherin family member 6; pemphigus vulgaris antigen; 130-kD pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen;
Cat.#:DSG3-1795MTag:His|SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse DSG3 Protein (50-617 aa), His-SUMO-tagged
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Cat.#:DSG3-1838MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse DSG3 Protein (50-617 aa), His-tagged
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Cat.#:DSG3-461HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG3 Protein (50-615 aa), His-SUMO-tagged
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Cat.#:DSG3-38HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human DSG3, Fc-tagged
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Cat.#:DSG3-668HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG3 Protein, His/GST-tagged
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Involved Pathway

DSG3 involved in several pathways and played different roles in them. We selected most pathways DSG3 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
CASP4; IRAK4; CYCS; BOK; STK24B; NFKBIAA; PIK3CB; IL3RA; H1F0; BAD
Apoptotic cleavage of cell adhesion proteins
DSG2; CTNNB1; DSG3; PKP1; CTNNB2; OCLN; DSG1; PTBP3; DSP
Apoptotic cleavage of cellular proteins
STK24; VIML; CTNNB1; CASP6L2; PKP1; OCLN; PLECA; DSG1; PTBP3; CASP6L1
Apoptotic execution phase
VIML; DBNLA; PANK1A; OCLN; SPNA2; HMGB2; BMX; DFFA; DNM1L; STK24A
Programmed Cell Death
ADD1; DIABLO; GZMC; PLECA; DNM1L; RNF8; DIABLOA; RIPK3; CASP6L2; CASP6L1

Protein Function

DSG3 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG3 itself. We selected most functions DSG3 had, and list some proteins which have the same functions with DSG3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein SGCA; PLCG1; MFGE8A; F2; CAPN8; DLK2; PCDH2G16; ANXA11B; DLA; SPNA1

DSG3 Related Articles

Di Zenzo, G; Zambruno, G; et al. Clonal Analysis of B-Cell Response in Pemphigus Course: Toward More Effective Therapies. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:651-654(2015).
Hammers, CM; Chen, J; et al. Persistence of Anti-Desmoglein 3 IgG(+) B-Cell Clones in Pemphigus Patients over Years. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:742-749(2015).