dsg4
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  • Official Full Name
  • Desmocollin 4
  • Background
  • DSG4 (Desmoglein 4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
  • Synonyms
  • DSG4; desmoglein 4; LAH; CDGF13; CDHF13; desmoglein-4; CDH family member 13; cadherin family member 13; OTTHUMP00000162820
Cat.#:DSG4-2891HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DSG4 Protein, GST-tagged
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Cat.#:DSG4-12180HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG4, GST-tagged
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Cat.#:DSG4-4844MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DSG4 Protein
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Cat.#:DSG4-1962RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DSG4 Protein
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Cat.#:DSG4-6806HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DSG4 293 Cell Lysate
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Protein Function

DSG4 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG4 itself. We selected most functions DSG4 had, and list some proteins which have the same functions with DSG4. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein ANXA4; PCDH2AB9; THBD; TNNC1A; CAPSLA; HSP90B1; EDEM2; EHD2; PCDH2AB1; RYR3

Interacting Protein

DSG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG4.
GABARAPL2